| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
M. genitalium （MG）is one of pathogen for male urethritis. Recently, treatment-failure cases of M. genitalium urethritis are increasing. We studied the relationship between antimicrobial resitance and genetic mutations of MG. However, the isolation and culturing of MG have still difficult and we isolated first MG strain with multi-drug resistance was isolated in Japan. Almost 40 % MG strains in Japan are macrolide-resistance. Against these macrolide-resistant strains, moxifloxacin(MFLX) or sitafloxacin(STFX) are effective. We indicated the possibility that the point mutation on parC gene in MG induces MFLX-resistance and additional mutation on gyrA gene induces STFX-resistance.
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