Study of antimicrobial therapy for Mycoplasma genitalium urethritis
| Project/Area Number |
26462456
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
松本 哲朗 産業医科大学, 医学部, 名誉教授 (50150420)
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| Research Collaborator |
JENSEN Jorgen Skov
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | Mycoplasma genitalium / 尿道炎 / sitaloxacin 耐性 / moxifloxacin 耐性 / マクロライド耐性 / 分離培養 / マイコプラズマ・ジェニタリウム / 抗菌薬治療 / 薬剤耐性 / moxifloxacin耐性 / Ｍ．ｇｅｎｉｔａｌｉｕｍ / キノロン耐性 / 遺伝子変異 / 培養 / キノロン耐性決定領域 / MIC |
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| Outline of Final Research Achievements |
M. genitalium （MG）is one of pathogen for male urethritis. Recently, treatment-failure cases of M. genitalium urethritis are increasing. We studied the relationship between antimicrobial resitance and genetic mutations of MG. However, the isolation and culturing of MG have still difficult and we isolated first MG strain with multi-drug resistance was isolated in Japan. Almost 40 % MG strains in Japan are macrolide-resistance. Against these macrolide-resistant strains, moxifloxacin(MFLX) or sitafloxacin(STFX) are effective. We indicated the possibility that the point mutation on parC gene in MG induces MFLX-resistance and additional mutation on gyrA gene induces STFX-resistance.
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Report
(5 results)
Research Products
(21 results)
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[Journal Article] Japanese guideline for clinical research of antimicrobial agents on urogenital infections: second edition.2016
Author(s)
Yasuda M, Muratani T, Ishikawa K, Kiyota H, Sakata H, Shigemura K, Takahashi S, Hamasuna R, Hayami H, Mikamo H, Yamamoto S, Watanabe T, Arakawa S.
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Journal Title
Journal of Infection and Chemotherapy
Volume: 22
Issue: 10
Pages: 651-661
DOI
Related Report
Peer Reviewed
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[Presentation] Antimicrobial susceptibility of Neisseria gonorrhoeae strains from male urethritis in Japan: surveillance at 2012-20132015
Author(s)
Hamasuna R, Yasuda M, Ishikawa K, Uehara S, Hayami H, Takahashi S, Matsumoto T, Yamamoto S, Hanaki H, Kadota J
Organizer
2015 World STI & HIV Congress and Australasian HIV&AIDS Conference
Place of Presentation
Brisbane, Australia
Year and Date
2015-09-13
Related Report
Int'l Joint Research
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