| Project/Area Number |
26462457
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
中川 由紀 新潟大学, 医歯学総合病院, 助教 (70422607)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | ABO血液型不適合腎移植 / 免疫学的順応 / 抗体関連型拒絶反応 / 血栓性微小血管障害 / ADAMTS13 / ｖWF / 免疫学的不応答性 / PECAM-1 / vWF / 血液型糖鎖抗原 / 血管内皮細胞 / アンカー蛋白 |
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| Outline of Final Research Achievements |
It has been still unknown that the establishment and maintenance mechanism of immunological accommodation after ABO-incompatible kidney transplantation.
Even now, antibody mediated rejection(AMR) and/or thrombotic microangiopathy(TMA) sometimes occurs in several cases. We have focused on the graft factor in which kidney endothelium express the blood type carbohydrate antigen with specific anchor proteins such as PECAM-1, vWF,ADAMTS-13 that is quite different from RBCs, which play a critical role in prevention of AMR and/orTMA and induction of accommodation. On the other hand, we have also found the recipient factor in which the donor-blood type specific inhibition of antibody production. We have approved it both in vivo and in vitro study. B cells derived from the patients have revealed that the immunological unresponsiveness, so-called B cell anergy against donor blood type antigen, which might be the real feature of the accommodation after ABO-incompatible kidney transplantation,
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