ADAMTS13, vWF and Immunological accommodation in renal injury after ABO-incompatible kidney transplantation
| Project/Area Number |
26462457
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
中川 由紀 新潟大学, 医歯学総合病院, 助教 (70422607)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | ABO血液型不適合腎移植 / 免疫学的順応 / 抗体関連型拒絶反応 / 血栓性微小血管障害 / ADAMTS13 / ｖWF / 免疫学的不応答性 / PECAM-1 / vWF / 血液型糖鎖抗原 / 血管内皮細胞 / アンカー蛋白 |
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| Outline of Final Research Achievements |
It has been still unknown that the establishment and maintenance mechanism of immunological accommodation after ABO-incompatible kidney transplantation.
Even now, antibody mediated rejection(AMR) and/or thrombotic microangiopathy(TMA) sometimes occurs in several cases. We have focused on the graft factor in which kidney endothelium express the blood type carbohydrate antigen with specific anchor proteins such as PECAM-1, vWF,ADAMTS-13 that is quite different from RBCs, which play a critical role in prevention of AMR and/orTMA and induction of accommodation. On the other hand, we have also found the recipient factor in which the donor-blood type specific inhibition of antibody production. We have approved it both in vivo and in vitro study. B cells derived from the patients have revealed that the immunological unresponsiveness, so-called B cell anergy against donor blood type antigen, which might be the real feature of the accommodation after ABO-incompatible kidney transplantation,
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Report
(5 results)
Research Products
(70 results)
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[Journal Article] Ombitasvir-Paritaprevir-Ritonavir Therapy in a Kidney Transplant Recipient With Chronic Hepatitis C Virus Genotype 1 Infection: A Case Report on the Importance of Considering Drug-Drug Interactions and Monitoring Cyclosporine Levels.2018
Author(s)
Takamura M, Yoshida T, Takahashi K, Hayashi K, Hashimoto S, Yamagiwa S, Tasaki M, Nakagawa Y, Saito K, Tanabe Y, Tomita Y, Terai S.
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Journal Title
Transplantation Proceedings
Volume: 50
Issue: 3
Pages: 884-886
DOI
Related Report
Peer Reviewed
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[Journal Article] A comparative study of the ATP concentrations in the peripheral CD4+ lymphocytes of living donor and cadaveric donor renal transplant recipients.2017
Author(s)
Sugiyama K, Tsukaguchi M, Kusano J, Isogai K, Sasahara H, Suzuki N, Toyama A, Nakagawa Y, Saito K, Takahashi K, Hirano T.
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Journal Title
Current Topics in Pharmacology
Volume: 印刷中
Related Report
Peer Reviewed
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[Journal Article] Results of a multicenter prospective clinical study in Japan for evaluating efficacy and safety of desensitization protocol based on rituximab in ABO-incompatible kidney transplantation2017
Author(s)
Kota Takahashi, Kazuhide Saito, Shiro Takahara, Shohei Fuchinoue, Takashi Yagisawa, Atsushi Aikawa, Yoshihiko Watarai, Norio Yoshimura, Kazunari Tanabe, Munio Morozumi, The IDC-C2B8 ABO-IKTx Study Group
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Journal Title
Clin Exp Nephrol
Volume: 21
Issue: 4
Pages: 705-713
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Relationship between the Peripheral Lymphocyte Response to Mycophenolic Acid in vitro and the Level of ATP in Peripheral CD4+ Lymphocytes before and after Renal Transplantation.2014
Author(s)
Sugiyama K, Tsukaguchi M, Sasahara H, Isogai K, Toyama A, Satoh H, Saito K, Nakagawa Y, Takahashi K, Tanaka S, Onda K, Hirano T.
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Journal Title
Drug Res (Stuttg)
Volume: Epub
Issue: 12
Pages: 629-634
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Benefit of desensitization with rituximab from the viewpoint of anti-A/B antibody titer2015
Author(s)
K Saito, S Takahara, N Yoshimura, A Aikawa, S Fuchinoue, T Yagisawa, K Tanabe, Y Watarai, M Shimazu, K Morozumi and K Takahashi
Organizer
ASN Kidney Week 2015
Place of Presentation
San Diego, CA, USA.
Year and Date
2015-11-03
Related Report
Int'l Joint Research
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[Presentation] Present Status of ABO Incompatible Kidney Transplantation in Japan -Lessons From More Than 2,400 Cases to Date-.2014
Author(s)
K. Saito, A. Aikawa, S. Takahara, S. Teraoka, S. Fuchinoue, N. Yoshimura, K. Uchida, K. Tanabe, T. Kinukawa, Y. kamiryo, K. Yamada, C. Ohyama, S. Sato, K. Takahashi
Organizer
World Transplant Congress2014
Place of Presentation
San Francisco, CA, USA
Year and Date
2014-07-26 – 2014-07-31
Related Report
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