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The prevention against chronic antibody mediated rejection on graft endothelial

Research Project

Project/Area Number 26462458
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Urology
Research InstitutionAichi Medical University (2015-2016)
Nagoya University (2014)

Principal Investigator

Iwasaki Kenta  愛知医科大学, 医学部, 准教授 (10508881)

Co-Investigator(Kenkyū-buntansha) 小林 孝彰  愛知医科大学, 医学部, 教授 (70314010)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords移植免疫 / 免疫順応 / 腎移植 / シグナル伝達 / 細胞保護 / HLA-class II / HLA / Accommodation / Signal tranduction
Outline of Final Research Achievements

Donor-specific antibody (DSA), particularly against HLA class II, is a major cause of chronic antibody-mediated rejection (CAMR) after transplantation, although ABO-incompatible kidney transplantation has recently demonstrated favorable graft outcomes. The condition of no injury even in the presence of anti-donor antibody has been referred to as “accommodation”, which would be one of the key factors for successful long-term graft survival. The purpose of this study was to analyze the beneficial effect of anti-blood group A/B antibody ligation on endothelial cells against HLA-DR antibody-mediated, complement-dependent cytotoxicity (CDC). Pre-incubation with anti-blood group A/B antibody had resistance to HLA-DR antibody-mediated CDC. This finding was ascribed to decreased expression of HLA-DR by post-translational regulation and increased expression of CD55/59, which was related to ERK and mTOR pathway inhibition.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (7 results)

All 2017 2016 2015 2014

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (5 results) (of which Int'l Joint Research: 2 results) Book (1 results)

  • [Journal Article] Negative Regulation of HLA-DR Expression on Endothelial Cells by Anti-A/B Antibody Ligation and mTOR Inhibition2017

    • Author(s)
      Iwasaki K, Miwa Y, Haneda M, Uchida K, Kodera Y, Kobayashi T
    • Journal Title

      Transplant Immunology

      Volume: 40 Pages: 22-30

    • DOI

      10.1016/j.trim.2016.12.004

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Presentation] mTOR経路の阻害によりIFNγ誘導性のHLA class II DRの発現を抑制する2016

    • Author(s)
      岩﨑研太、前仲亮宏、三輪祐子、小林孝彰
    • Organizer
      第43回日本臓器保存生物医学会
    • Place of Presentation
      東京
    • Year and Date
      2016-11-26
    • Related Report
      2016 Annual Research Report
  • [Presentation] The preventative effect of mTOR inhibition by anti-A/B antibody ligation and mTOR-inhibitor on anti-HLA-DR antibody mediated complement dependent cytotoxicity.2016

    • Author(s)
      Kenta Iwasaki, Yuko Miwa, Kazuharu Uchida, and Takaaki Kobayashi
    • Organizer
      26th TTS
    • Place of Presentation
      Hong Kong
    • Year and Date
      2016-08-18
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Human Endothelial Cell Activation through ERK by Non-Gal Antibody2015

    • Author(s)
      Kenta Iwasaka、Yukiko Inanaga、Yuko Miwa、Masataka Haneda、Akira Onishi、Haruko Ogawa、Takaaki Kobayashi
    • Organizer
      国際異種移植学会
    • Place of Presentation
      メルボルン
    • Year and Date
      2015-11-15
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 翻訳後修飾による抗A/B抗体接着を介した 内皮細胞上IFNγ誘導性HLA class II DRの発現減少2015

    • Author(s)
      岩崎研太、三輪祐子、羽根田正隆、小林孝彰
    • Organizer
      組織適合性学会2015/9/10~12
    • Place of Presentation
      水戸
    • Year and Date
      2015-09-10
    • Related Report
      2015 Research-status Report
  • [Presentation] ABO不適合移植における抗体関連型拒絶反応軽減は、HLA class II DR発現抑制に起因する2014

    • Author(s)
      岩﨑研太、山本貴之、平光高久、三輪裕子、羽根田正隆、片山昭男、片山昭男、山上孝子、鳴海俊治、渡井至彦、武田朝美、小林孝彰
    • Organizer
      第50回移植学会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2014-09-12
    • Related Report
      2014 Research-status Report
  • [Book] 臨床と病理2016

    • Author(s)
      移植免疫の基礎:Accommodation(免疫順応)
    • Total Pages
      7
    • Publisher
      文光堂
    • Related Report
      2015 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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