Development of diagnostic procedure and novel treatment of amniotic fluid embolism based on the pathological histology
| Project/Area Number |
26462482
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
Tamura Naoaki 浜松医科大学, 医学部附属病院, 助教 (90402370)
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| Co-Investigator(Kenkyū-buntansha) |
谷口 千津子 浜松医科大学, 医学部附属病院, 診療助教 (20397425)
金山 尚裕 浜松医科大学, 医学部, 理事 (70204550)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 羊水塞栓症 / 子宮弛緩 / 後産期出血 / アナフィラクトイド反応 / 後産期急性子宮筋層炎 / C1インヒビター / 子宮収縮関連タンパク質 / ブラジキニン受容体 / C1インヒビター濃縮製剤 |
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| Outline of Final Research Achievements |
In the myometrium of amniotic fluid embolism presenting with treatment-resistant postpartum hemorrhage, the infiltration of neutrophil, macrophage and activated mast cells expressed the receptor for anaphylatoxin were characteristic finding. This could be histopathologically expressed as postpartum acute myometritis that causes tissue edema. C1 esterase inhibitor (C1INH), potentially inhibits anaphylactoid reaction and vascular permeability, exhibited the effect of uterine contraction. This result suggested C1INH can be one of therapeutic products for amniotic fluid embolism with refractory uterin atony.
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Report
(4 results)
Research Products
(29 results)
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[Journal Article] Histological characteristics of the myometrium in the postpartum hemorrhage of unknown etiology: a possible involvement of local immune reactions2015
Author(s)
Farhana M, Tamura N, Mukai M, Ikuma K, Koumura Y, Furuta N, Yaguchi C, Uchida T, Suzuki K, Sugihara K, Itoh H, Kanayama N
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Journal Title
J Reprod Immunol
Volume: 110
Pages: 74-80
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Morphological characteristics of the placental basal plate in IVF pregnancies: a possible association with the amount of bleeding in delivery2015
Author(s)
Yuki Nakamura,Chizuko yaguchi,Hiroaki Itoh Ryoko Sakamoto,Takako Kimura,Naomi Furuta,Toshiyuki Uchida,Naoaki Tamura,Kazunao Suzuki,Kazuhiro Sumimoto,Yumiko Matsuda,Toshiki Matsura,Mitsura Nishimura,Naohiro Kanayama
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Journal Title
Human Pathology
Volume: inprint
Issue: 8
Pages: 1171-1179
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Undernourishment in utero Primes Hepatic Steatosis in Adult Mice Offspring on an Obesogenic Diet; Involvement of Endoplasmic Reticulum Stress2015
Author(s)
Muramatsu-Kato K, Itoh H, Kohmura-Kobayashi Y, Ferdous UJ, Tamura N, Yaguchi C, Uchida T, Suzuki K, Hashimoto K, Suganami T, Ogawa Y, Kanayama N
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Journal Title
Sci Rep
Volume: 5
Issue: 1
Pages: 16867-16867
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Development of pro-apoptotic peptides as potential therapy for peritoneal endometriosis.2014
Author(s)
Sugihara K, Kobayashi Y, Suzuki A, Tamura N, Motamedchaboki K, Huang CT, Akama TO, Pecotte J, Frost P, Bauer C, Jimenez JB Jr, Nakayama J, Aoki D, Fukuda MN.
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Journal Title
Nature Communications
Volume: 5:4478
Issue: 1
Pages: 1-9
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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