The new therapeutic approach for reduction of severe complication in preterm neonates
Project/Area Number |
26462484
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Obstetrics and gynecology
|
Research Institution | Nagoya University |
Principal Investigator |
Kotani Tomomi 名古屋大学, 医学系研究科, 講師 (70359751)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 炎症 / 酸化ストレス / IL-6 / 神経障害 / LPS / 分子状水素 / ET-1 / 絨毛膜羊膜炎 / エンドセリン / TLR / 気管支肺異形成 / 脳障害 / 水素 |
Outline of Final Research Achievements |
In mouse model of fetal brain damage caused by maternal inflammation, the effect of prenatal administration of molecular hydrogen was examined. In this research, maternal inflammation raised overproduction of pro-inflammatory cytokines and the induction of oxidative stress in fetal brain, followed by increased number of apoptotic cells. In addition, excessive activated microglia is involved in this inflammation and oxidative stress induced brain damage. Molecular hydrogen repressed microglia, which is suggested to play a protective role against inflammation and oxidative stress induced brain damage.In addition, maternal administration of molecular hydrogen reduced the inflammation at the maternal-fetal interface, which is also related with the protective role against fetal brain damage.
|
Report
(4 results)
Research Products
(8 results)
-
[Journal Article] Molecular hydrogen ameliorates several characteristics of preeclampsia in the Reduced Uterine Perfusion Pressure (RUPP) rat model.2016
Author(s)
Ushida T, Kotani T, Tsuda H, Imai K, Nakano T, Hirako S, Ito Y, Li H, Mano Y, Wang J, Miki R, Yamamoto E, Iwase A, Bando YK, Hirayama M, Ohno K, Toyokuni S, Kikkawa F.
-
Journal Title
FREE RADICAL BIOLOGY AND MEDICINE
Volume: 101
Pages: 524-533
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
-
[Journal Article] Neuroprotective potential of molecular hydrogen against perinatal brain injury via suppression of activated microglia2016
Author(s)
Imai K, Kotani T, Tsuda H, Mano Y, Nakano T, Ushida T, Li H, Miki R, Sumigama S, Iwase A, Hirakawa A, Ohno K, Toyokuni S, Takeuchi H, Mizuno T, Suzumura A, Kikkawa F
-
Journal Title
Free Radic Biol Med.
Volume: 91
Pages: 154-63
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
-
[Journal Article] Maternal molecular hydrogen administration on lipopolysaccharide-induced mouse fetal brain injury2015
Author(s)
Nakano T, Kotani T, Mano Y, Tsuda H, Imai K, Ushida T, Li H, Miki R, Sumigama S, Sato Y, Iwase A, Hirakawa A, Asai M, Toyokuni S, Kikkawa F.
-
Journal Title
Journal of Clinical Biochemistry and Nutrition
Volume: 57
Issue: 3
Pages: 178-182
DOI
NAID
ISSN
0912-0009, 1880-5086
Related Report
Peer Reviewed / Open Access
-
[Journal Article] Maternal molecular hydrogen treatment attenuates lipopolysaccharide-induced rat fetal lung injury.2015
Author(s)
Hattori Y, Kotani T, Tsuda H, Mano Y, Tu L, Li H, Hirako S, Ushida T, Imai K, Nakano T, Sato Y, Miki R, Sumigama S, Iwase A, Toyokuni S, Kikkawa F.
-
Journal Title
Free radical research.
Volume: 49
Issue: 8
Pages: 1026-37
DOI
Related Report
Peer Reviewed / Open Access
-
-
-