| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
The relationship between emotional stress and infertility has been widely accepted. Manserin is distributed in the neuroendocrine system and its expression in the adrenal gland is stress dependent. Recently, I found the localization of manserin in the oviduct of female rats. In this study, I investigated the relationship between manserin and estrus cycle, development or stress condition.
Manserin immunoreactivity was detected on the surface of the oviduct at postnatal day 14. Localization of manserin in the oviduct was not changed with estrus cycle or stress. Manserin was colocalized with the dopaminergic neuron marker, tyrosine hydroxylase, at the arcuate nucleus of hypothalamus. These results suggest that manserin may be involved in the regulation of hypothalamus-pituitary-gonad axis.
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