Stress response system by Thioredoxin binding protein-2: TBP-2/Txnip in utero during pregnancy

Research Project

Project/Area Number	26462487
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Obstetrics and gynecology
Research Institution	Kyoto University
Principal Investigator	Yura Shigeo 京都大学, 医学研究科, 非常勤講師 (60335289)
Co-Investigator(Renkei-kenkyūsha)	KONDOH Eiji 京都大学, 医学研究科, 講師 (10544950) MOGAMI Haruta 京都大学, 医学研究科, 助教 (40378766)
Research Collaborator	CHIGUSA Yoshitsugu
Project Period (FY)	2014-04-01 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000) Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords	妊娠 / 胎盤 / 胎児 / チオレドキシン / 産婦人科学 / 低酸素 / 妊娠高血圧症
Outline of Final Research Achievements	Pregnancy induced hypertension (PIH) is a major cause of fetal growth restriction (FGR). Thioredoxin binding protein-2 (TBP-2), which is identical with thioredoxin interacting protein (Txnip) is recently reported to control cellular proliferation and differentiation and to be involved in glucose and lipid homeostasis. In PIH with FGR pregnancy, TBP-2 / Txnip gene expression was significantly low compared to that in normal term placenta. In placental explant culture, hypoxia decreased TBP-2 / Txnip gene expression. In TBP-2 knockout mouse placenta, deletion of TBP-2 significantly suppressed mRNA level of Peroxisome Proliferators-Activated Receptors (PPARs), key transcriptional factors of placenta development. We demonstrated a possibility that TBP-2 might contribute to the regulation of placental development and function during pregnancy.