Drug Repositioning for Preeclampsia Therapeutics by In Vitro Screening.
| Project/Area Number |
26462488
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Obstetrics and gynecology
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
味村 和哉 大阪大学, 医学系研究科, 助教 (50437422)
冨松 拓治 大阪大学, 医学系研究科, 講師 (30346209)
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Keywords | 妊娠高血圧症候群 / sFlt1 / sEng / vardenafil / 骨髄細胞移植 / 免疫寛容 / 妊娠性高血圧症候群 / 既存薬ライブラリー / soluble Endoglin / placental growth factor / HUVEC |
|---|
| Outline of Final Research Achievements |
Preeclampsia, a pregnancy disorder characterized by hypertension in association with proteinuria, is detected as a complication in 3-5% of all pregnancies 1 and is the leading cause of maternal and perinatal morbidity and mortality worldwide. Currently, preeclampsia cannot be prevented, and termination of pregnancy remains the only approach to treat preeclampsia.
By drug repositioning process through screening a library of approved drugs, we identified vardenafil which induced PlGF production from HUVEC. Although we showed that vardenafil induced PlGF production from BeWo cell, we could not show clear dose-response relation.
Further work is needed to determine whether vardenafil can be used for preeclampsia therapeutics before testing it in humans.
|
Report
(4 results)
Research Products
(28 results)
-
[Journal Article] Prenatal and Postnatal Clinical Course of an Urachus Identified as an Allantoic Cyst in the Umbilical Cord.2016
Author(s)
Umeda S, Usui N, Kanagawa T, Yamamichi T, Nara K, Ueno T, Owari M, Uehara S, Oue T, Kimura T, Okuyama H.
-
Journal Title
European Journal of Pediatric Surgery
Volume: 26
Issue: 02
Pages: 200-202
DOI
Related Report
Peer Reviewed
-
-
-
-
[Journal Article] Expression levels of ABCG2 on cord red blood cells and study of fetal anemia associated with anti-Jr(a).2016
Author(s)
Fujita S, Kashiwagi H, Tomimatsu T, Ito S, Mimura K, Kanagawa T, Endo M, Miyoshi T, Okamura Y, Tani Y, Tomiyama Y, Kimura T.
-
Journal Title
Transfusion.
Volume: 56
Issue: 5
Pages: 1171-1181
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
[Journal Article] A survey on awareness of genetic counseling for non-invasive prenatal testing: the first year experience in Japan.2016
Author(s)
Yotsumoto J, Sekizawa A, Suzumori N, Yamada T, Katagiri Y, Takeshita N, Ogawa M, Okai T, Izumi S, Hamanoue H, Inuzuka M, Haino K, Hamajima N, Nishizawa H, Okamoto Y, Nakamura H, Kanagawa T, 他28名; Japan NIPT Consortium.
-
Journal Title
J Hum Genet.
Volume: 61
Issue: 12
Pages: 995-1001
DOI
Related Report
Peer Reviewed
-
-
-
-
-
[Journal Article] Drug Repositioning for Preeclampsia Therapeutics by In Vitro Screening: Phosphodiesterase-5 Inhibitor Vardenafil Restores Endothelial Dysfunction via Induction of Placental Growth Factor.2015
Author(s)
Kakigano A, Tomimatsu T, Mimura K, Kanayama T, Fujita S, Minato K, Kumasawa K, Taniguchi Y, Kanagawa T, Endo M, Ishihara T, Namba T, Mizushima T, Kimura T.
-
Journal Title
Reprod Sci.
Volume: 12
Pages: 133-135
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
[Journal Article] Three-dimensional sonography in the differential diagnosis of interstitial, angular, and intrauterine pregnancies in a septate uterus2014
Author(s)
Tanaka, Y. Mimura, K. Kanagawa, T. Kajimoto, E. Takahashi, K. Kakigano, A. Fujita, S. Kinugasa-Taniguchi, Y. Endo, M. Kimura, T.
-
Journal Title
J Ultrasound Med
Volume: 33
Issue: 11
Pages: 2031-2035
DOI
Related Report
Peer Reviewed / Open Access
-
[Presentation] Development of human antigen presenting cells in human IL3/GM-CSF-transgenic NOG mice liver2016
Author(s)
Seiichi Tawara1, Tomohide Tatsumi1, Hayato Hikita1, Haruki Kimura1, Shigeki Suemura1, Atsuo Takigawa1, Tadashi Kegasawa1, Takahiro Suda1, Akira Nishio1, Takahiro Kodama1, Minoru Shigekawa1, Ryotaro Sakamori1, Takeshi Kanagawa2, Takeshi Takahashi3, Hiroshi Suemizu3 and Tetsuo Takehara1
Organizer
The Liver Meeting2016@AASLD
Place of Presentation
ボストン（アメリカ）
Year and Date
2016-11-11
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
