Autoantibody to beta2GPI/MHC class II and obstetrical complications
| Project/Area Number |
26462489
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kobe University |
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Principal Investigator |
Yamada Hideto 神戸大学, 医学研究科, 教授 (40220397)
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| Co-Investigator(Kenkyū-buntansha) |
出口 雅士 神戸大学, 医学部附属病院, 助教 (50403291)
谷村 憲司 神戸大学, 医学部附属病院, 講師 (80593988)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 抗リン脂質抗体 / 不育症 / MHC / β2GPI |
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| Outline of Final Research Achievements |
This prospective study aimed to investigate whether aB2GPI/HLA-II is associated with recurrent pregnancy loss (RPL). Serum level of aB2GPI/HLA-II as well as common aPL (aCL IgG/IgM, aCLB2GPI IgG and LA) in all subjects were measured. The normal range of serum aB2GPI/HLA-II level was established by using the 99th percentile cutoff point for 100 fertile controls. The median (range) serum levels of aB2GPI/HLA-II in control population was 0 (0-308.2) U, and the normal range of it was determined to be 52.6 U or less.One hundred and eight women with RPL were enrolled from December 2016 to September 2017, and serum levels of aB2GPI/HLA-II in them was found to be median 10.3 (range, 0-1952.0) U. Twenty-three (21%) of the 108 women with RPL tested positive for aB2GPI/HLA-II. Seventeen (74%) of the 23 women tested negative for common aPL. Twelve (52%) of the 23 women had unexplained RPL. A novel antibody against B2GPI/HLA-II complexes may be involved in the pathology of RPL.
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Report
(5 results)
Research Products
(20 results)
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[Journal Article] β2-glycoprotein I/ HLA class II complexes are novel autoantigens in antiphospholipid syndrome.2015
Author(s)
Tanimura K, Jin H, Suenaga T, Morikami S, Arase N, Kishida K, Hirayasu K, Kohyama M, Ebina Y, Yasuda S, Horita T, Takasugi K, Ohmura K, Yamamoto K, Katayama I, Sasazuki T, Lanier LL, Atsumi T, Yamada H, Arase H.
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Journal Title
Blood
Volume: 125
Issue: 18
Pages: 2835-2844
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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