| Project/Area Number |
26462489
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kobe University |
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Principal Investigator |
Yamada Hideto 神戸大学, 医学研究科, 教授 (40220397)
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| Co-Investigator(Kenkyū-buntansha) |
出口 雅士 神戸大学, 医学部附属病院, 助教 (50403291)
谷村 憲司 神戸大学, 医学部附属病院, 講師 (80593988)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 抗リン脂質抗体 / 不育症 / MHC / β2GPI |
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| Outline of Final Research Achievements |
This prospective study aimed to investigate whether aB2GPI/HLA-II is associated with recurrent pregnancy loss (RPL). Serum level of aB2GPI/HLA-II as well as common aPL (aCL IgG/IgM, aCLB2GPI IgG and LA) in all subjects were measured. The normal range of serum aB2GPI/HLA-II level was established by using the 99th percentile cutoff point for 100 fertile controls. The median (range) serum levels of aB2GPI/HLA-II in control population was 0 (0-308.2) U, and the normal range of it was determined to be 52.6 U or less.One hundred and eight women with RPL were enrolled from December 2016 to September 2017, and serum levels of aB2GPI/HLA-II in them was found to be median 10.3 (range, 0-1952.0) U. Twenty-three (21%) of the 108 women with RPL tested positive for aB2GPI/HLA-II. Seventeen (74%) of the 23 women tested negative for common aPL. Twelve (52%) of the 23 women had unexplained RPL. A novel antibody against B2GPI/HLA-II complexes may be involved in the pathology of RPL.
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