The study of the prediction, prevention and treatment of preeclampsia
| Project/Area Number |
26462496
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Aichi Medical University (2015-2017)
Nagoya City University (2014) |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 妊婦の高血圧 / 血管内皮機能 / 酸化ストレス / eNOS uncoupling / 診察室外血圧 / 動物モデル / 産科ストレス / uncoupling / 降圧治療 / 発症予防 / 夜間高血圧 / 経口降圧治療 / 注射薬の降圧治療 / 24h ABPM / 血圧の日内変動 / サプリメント / 降圧剤 |
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| Outline of Final Research Achievements |
We performed home blood pressure measurement in hypertensive disorders of pregnancy (HDP) patients and determined abnormality of circadian rhythm and persistence of hypertension in postpartum. Also, we studied HDP management with antihypertensive medications. These results were useful for both prediction and management of HDP and index of future hypertension.
We measured the reactive oxygen species (ROS) of HDP in vascular tissue and blood and made clear that ROS were involved in the pathogenesis of HDP. These results suggested that there might be next stage secondary to 2step theory in the pathogenesis. Furthermore, the oxidation of tetrahydrobiopterin by peroxynitrite might induce endothelial NO synthase uncoupling. These results suggested that the folic acid administration was a novel treatment of HDP instead of anti-oxidant administration.
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Report
(5 results)
Research Products
(64 results)
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[Journal Article] A review of Best Practice Guide 2015 for Care and Treatment of Hypertension in Pregnancy.2015
Author(s)
Takagi K, Yamasaki M, Nakamoto O, Saito S, Suzuki H, Seki H, Takeda S, Ohno Y, Sugimura M, Suzuki Y, Watanabe K, Matsubara K, Makino S, Metoki H, Yamamoto T.
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Journal Title
Hypertens Res Pregnancy
Volume: 2
Issue: 2
Pages: 65-103
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Presentation] 遺伝性血管性浮腫合併妊娠の一例.2016
Author(s)
山本珠生, 鈴木佳克, 二井章太, 松下宏, 若槻明彦, 坂野章吾.
Organizer
第103回愛知産科婦人科学会学術講演会
Place of Presentation
興和紡績本社ビル
Year and Date
2016-07-02
Related Report
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[Presentation] 妊娠高血圧症候群では夕方より夜間に血圧が上昇するものが多い.2015
Author(s)
森亮介, 鈴木佳克, 松浦綾乃, 十河千恵, 川端俊一, 中元永理, 坪井文菜, 加藤智子, 関宏一郎, 西川尚実, 六鹿正文, 柴田金光, 山本珠生.
Organizer
第135回東海産科婦人科学会
Place of Presentation
名古屋国際会議場 (愛知県名古屋市)
Year and Date
2015-02-21 – 2015-02-22
Related Report
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[Presentation] ニカルジピン注射薬降圧スライディングスケールによる降圧治療のpreeclampsiaとgestational hypertensionの差違.2015
Author(s)
松浦綾乃, 鈴木佳克, 荒川 友恵, 十河千恵, 川端俊一, 中元永理, 坪井文菜, 加藤智子, 関宏一郎, 西川尚実, 六鹿正文, 柴田金光.
Organizer
第135回東海産科婦人科学会
Place of Presentation
名古屋国際会議場 (愛知県名古屋市)
Year and Date
2015-02-21 – 2015-02-22
Related Report
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[Presentation] 子癇患者における血圧の変動とMRI所見の変化に関する検討.2014
Author(s)
松浦 綾乃, 鈴木 佳克, 川端 俊一, 加藤 智子, 関 宏一郎, 西川 尚実, 六鹿 正文, 柴田 金光, 山本 珠生.
Organizer
第66回日本産科婦人科学会学術講演会
Place of Presentation
東京国際フォーラム (東京都千代田区)
Year and Date
2014-04-18 – 2014-04-20
Related Report
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