The management of labor and fetal cerebral oxygenation: the importance of carbon dioxide
| Project/Area Number |
26462506
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
中村 隆文 川崎医科大学, 医学部, 教授 (20303969)
村田 卓也 川崎医科大学, 医学部, 講師 (20714207)
下屋 浩一郎 川崎医科大学, 医学部, 教授 (40291950)
中井 祐一郎 川崎医科大学, 医学部, 准教授 (50271193)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 胎児脳酸素化 / 二酸化炭素 / 胎児脳血流 / 二酸化炭素分圧 / 過換気 / 胎児脳循環 |
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| Outline of Final Research Achievements |
Fetal heart rate monitoring, which is supposed to detect the sign of fetal hypoxia, has not significantly reduced cerebral palsy. Maternal carbon dioxide levels show a close relation with fetal carbon dioxide levels. The fetal carbon dioxide level affects fetal cerebral oxygenation by regulating cerebral blood flow and shifting the oxyhemoglobin dissociation curve. Here, we evaluate fetal cerebral oxygenation using newly developed oximeter during labor and analyze its association with fetal carbon dioxide level, and found that umbilical venous blood carbon dioxide level showed significant positive correlations with fetal cerebral oxygenation. Based on the present findings, we would emphasize a possible relationship between maternal hyperventilation and a reduced fetal cerebral oxygenation, which may have been overlooked. In addition to fetal heart rate monitoring, one would be well advised to give increased attention to maternal carbon dioxide levels during labor.
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] Expression levels of ABCG2 on cord red blood cells and study of fetal anemia associated with anti-Jr(a).2016
Author(s)
Fujita S, Kashiwagi H, Tomimatsu T, Ito S, Mimura K, Kanagawa T, Endo M, Miyoshi T, Okamura Y, Tani Y, Tomiyama Y, Kimura T.
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Journal Title
Transfusion.
Volume: 56
Issue: 5
Pages: 1171-1181
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Drug repositioning for preeclampsia therapeutics by in vitro screening: phosphodiesterase-5 inhibitor vardenafil restores endothelial dysfunction via induction of placental growth factor2015
Author(s)
Kakigano, A. Tomimatsu, T. Mimura, K. Kanayama, T. Fujita, S. Minato, K. Kumasawa, K. Taniguchi, Y. Kanagawa, T. Endo, M. Ishihara, T. Namba, T. Mizushima, T. Kimura, T.
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Journal Title
Reproductive Sciences
Volume: 10
Issue: 10
Pages: 1272-80
DOI
Related Report
Peer Reviewed
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[Journal Article] Drug Repositioning for Preeclampsia Therapeutics by In Vitro Screening: Phosphodiesterase-5 Inhibitor Vardenafil Restores Endothelial Dysfunction via Induction of Placental Growth Factor.2015
Author(s)
Kakigano A, Tomimatsu T, Mimura K, Kanayama T, Fujita S, Minato K, Kumasawa K, Taniguchi Y, Kanagawa T, Endo M, Ishihara T, Namba T, Mizushima T, Kimura T.
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Journal Title
Reproductive Sciences
Volume: -
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Peer Reviewed
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[Presentation] In utero stem cell therapy for Osteogenesis Imperfecta : a clinical case report2016
Author(s)
Endo M, Takahashi K, Ito Y, Kanagawa T, Fukui O, Mimura K, Kakigano A, Shimazu Y, Kajimoto E, Itou Y, Tomimatsu T, Kimura T.
Organizer
第68回日本産科婦人科学会学術講演会
Place of Presentation
東京
Year and Date
2016-04-21
Related Report
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