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The management of labor and fetal cerebral oxygenation: the importance of carbon dioxide

Research Project

Project/Area Number 26462506
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Obstetrics and gynecology
Research InstitutionOsaka University

Principal Investigator

Tomimatsu Takuji  大阪大学, 医学系研究科, 講師 (30346209)

Co-Investigator(Kenkyū-buntansha) 中村 隆文  川崎医科大学, 医学部, 教授 (20303969)
村田 卓也  川崎医科大学, 医学部, 講師 (20714207)
下屋 浩一郎  川崎医科大学, 医学部, 教授 (40291950)
中井 祐一郎  川崎医科大学, 医学部, 准教授 (50271193)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords胎児脳酸素化 / 二酸化炭素 / 胎児脳血流 / 二酸化炭素分圧 / 過換気 / 胎児脳循環
Outline of Final Research Achievements

Fetal heart rate monitoring, which is supposed to detect the sign of fetal hypoxia, has not significantly reduced cerebral palsy. Maternal carbon dioxide levels show a close relation with fetal carbon dioxide levels. The fetal carbon dioxide level affects fetal cerebral oxygenation by regulating cerebral blood flow and shifting the oxyhemoglobin dissociation curve. Here, we evaluate fetal cerebral oxygenation using newly developed oximeter during labor and analyze its association with fetal carbon dioxide level, and found that umbilical venous blood carbon dioxide level showed significant positive correlations with fetal cerebral oxygenation. Based on the present findings, we would emphasize a possible relationship between maternal hyperventilation and a reduced fetal cerebral oxygenation, which may have been overlooked. In addition to fetal heart rate monitoring, one would be well advised to give increased attention to maternal carbon dioxide levels during labor.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (16 results)

All 2016 2015 2014

All Journal Article (13 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 13 results,  Open Access: 7 results,  Acknowledgement Compliant: 2 results) Presentation (3 results)

  • [Journal Article] Two consecutive pregnancies in a patient with paroxysmal nocturnal haemoglobinuria treated with anticoagulant therapy at different doses.2016

    • Author(s)
      Sasano T, Matsumura I, Kimura T ,et al.
    • Journal Title

      Blood Coagul Fibrinolysis.

      Volume: 27 Issue: 1 Pages: 109-112

    • DOI

      10.1097/mbc.0000000000000386

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Expression levels of ABCG2 on cord red blood cells and study of fetal anemia associated with anti-Jr(a).2016

    • Author(s)
      Fujita S, Kashiwagi H, Tomimatsu T, Ito S, Mimura K, Kanagawa T, Endo M, Miyoshi T, Okamura Y, Tani Y, Tomiyama Y, Kimura T.
    • Journal Title

      Transfusion.

      Volume: 56 Issue: 5 Pages: 1171-1181

    • DOI

      10.1111/trf.13515

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Guillain-Barré syndrome after trivalent influenza vaccination during pregnancy.2016

    • Author(s)
      Tomimatsu T, Sugihara M, Nagai T, Sunada Y, Kimura T, Shimoya K.
    • Journal Title

      Eur J Obstet Gynecol Reprod Biol.

      Volume: 201 Pages: 225-226

    • DOI

      10.1016/j.ejogrb.2016.03.031

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phase I Clinical Study of Irinotecan Plus S-1 in Patients With Advanced or Recurrent Cervical Cancer Previously Treated With Platinum-Based Chemotherapy.2016

    • Author(s)
      Mabuchi S, Yokoi E, Owa T, Kozasa K, Yamashita M, Kobayashi E, Tomimatsu T, Yoki T, Tsutui T, Kimura T.
    • Journal Title

      Int J Gynecol Cancer.

      Volume: 26 Issue: 7 Pages: 1281-1287

    • DOI

      10.1097/igc.0000000000000769

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Intense fluorodeoxyglucose uptake by a benign sclerosing stromal tumor of the ovary.2016

    • Author(s)
      Tomimatsu T, Fukuda Y, Mimura K, Yoshino K, Kato H, Tsuboyama T, Hori Y, Kimura T.
    • Journal Title

      Taiwan J Obstet Gynecol.

      Volume: 55 Issue: 6 Pages: 893-894

    • DOI

      10.1016/j.tjog.2016.03.005

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pathophysiology of preeclampsia: an angiogenic imbalance and long-lasting systemic vascular dysfunction.2016

    • Author(s)
      Tomimatsu T, Mimura K, Endo M, Kumasawa K, Kimura T.
    • Journal Title

      Hypertens Res

      Volume: 40(4) Issue: 4 Pages: 305-310

    • DOI

      10.1038/hr.2016.152

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Massive cystic degeneration of a uterine leiomyoma in a patient with autosomal dominant polycystic kidney disease.2015

    • Author(s)
      Tomimatsu T, Sugihara M, Nakamura T, Kashihara N, Shimoya K.
    • Journal Title

      Gynecologic and Obstetric Investigation

      Volume: 79 Issue: 3 Pages: 168-171

    • DOI

      10.1159/000369996

    • Related Report
      2015 Research-status Report 2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] [270-POS]: A possible therapeutic role of nicotine for preeclampsia2015

    • Author(s)
      Mimura, K. Tomimatsu, T. Kimura, T.
    • Journal Title

      Pregnancy Hypertens

      Volume: 5 Issue: 1 Pages: 135-135

    • DOI

      10.1016/j.preghy.2014.10.276

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Thrombocytopenia associated with Mycoplasma pneumonia during pregnancy: Case presentation and approach for differential diagnosis2015

    • Author(s)
      Nishikawa, A. Mimura, K. Kanagawa, T. Maeda, T. Tomimatsu, T. Kimura, T.
    • Journal Title

      Journal of Obstetrics and Gynaecology Research

      Volume: 41 Issue: 8 Pages: 1273-1277

    • DOI

      10.1111/jog.12713

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Drug repositioning for preeclampsia therapeutics by in vitro screening: phosphodiesterase-5 inhibitor vardenafil restores endothelial dysfunction via induction of placental growth factor2015

    • Author(s)
      Kakigano, A. Tomimatsu, T. Mimura, K. Kanayama, T. Fujita, S. Minato, K. Kumasawa, K. Taniguchi, Y. Kanagawa, T. Endo, M. Ishihara, T. Namba, T. Mizushima, T. Kimura, T.
    • Journal Title

      Reproductive Sciences

      Volume: 10 Issue: 10 Pages: 1272-80

    • DOI

      10.1177/1933719115574340

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Drug Repositioning for Preeclampsia Therapeutics by In Vitro Screening: Phosphodiesterase-5 Inhibitor Vardenafil Restores Endothelial Dysfunction via Induction of Placental Growth Factor.2015

    • Author(s)
      Kakigano A, Tomimatsu T, Mimura K, Kanayama T, Fujita S, Minato K, Kumasawa K, Taniguchi Y, Kanagawa T, Endo M, Ishihara T, Namba T, Mizushima T, Kimura T.
    • Journal Title

      Reproductive Sciences

      Volume: -

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Association between sexual health and delivery mode2014

    • Author(s)
      Song, M. Ishii, H. Toda, M. Tomimatsu, T. Katsuyama, H. Nakamura, T. Nakai, Y. Shimoya, K.
    • Journal Title

      Sex Med

      Volume: 2 Issue: 4 Pages: 153-158

    • DOI

      10.1002/sm2.46

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Abnormal pressure-wave reflection in pregnant women with chronic hypertension: association with maternal and fetal outcomes2014

    • Author(s)
      Tomimatsu, T. Fujime, M. Kanayama, T. Mimura, K. Koyama, S. Kanagawa, T. Endo, M. Shimoya, K. Kimura, T.
    • Journal Title

      Hypertens Res

      Volume: 37 Issue: 11 Pages: 989-992

    • DOI

      10.1038/hr.2014.109

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] In utero stem cell therapy for Osteogenesis Imperfecta : a clinical case report2016

    • Author(s)
      Endo M, Takahashi K, Ito Y, Kanagawa T, Fukui O, Mimura K, Kakigano A, Shimazu Y, Kajimoto E, Itou Y, Tomimatsu T, Kimura T.
    • Organizer
      第68回日本産科婦人科学会学術講演会
    • Place of Presentation
      東京
    • Year and Date
      2016-04-21
    • Related Report
      2016 Annual Research Report
  • [Presentation] Comparative analysis of 15-years ago and the current cesarean delivery rates using 10-group classification2016

    • Author(s)
      Owa T, Mimura K, Kakigano A, Matsumoto Y, Takata T, Matsuzaki S, Kumasawa K, Endo M, Tomimatsu T, Kimura T.
    • Organizer
      第68回日本産科婦人科学会学術講演会
    • Place of Presentation
      東京
    • Year and Date
      2016-04-21
    • Related Report
      2016 Annual Research Report
  • [Presentation] 分娩時の母体における不感蒸泄量に関する検討2014

    • Author(s)
      冨松拓治
    • Organizer
      第38回日本産科婦人科栄養・代謝研究会
    • Place of Presentation
      広島市
    • Year and Date
      2014-08-22
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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