Establishment of systematic, comprehensive perioperative VTE prophylaxis for patients with gynecologic cancer and elucidation of the mechanism of VTE development
Project/Area Number |
26462513
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Obstetrics and gynecology
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Research Institution | University of Tsukuba |
Principal Investigator |
Satoh Toyomi 筑波大学, 医学医療系, 教授 (80344886)
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Project Period (FY) |
2014-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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Keywords | 婦人科悪性腫瘍 / 静脈血栓塞栓症 / 予防 / 組織因子 / 血栓塞栓症 / 周術期 / 予防法 |
Outline of Final Research Achievements |
The aim of this study is to establish methods of postoperative symptomatic venous thromboembolism (VTE) prophylaxis for patients with ovarian, endometrial and cervical cancer. Before treatment, VTE screening was conducted including asymptomatic for them. When VTE was discovered in them, anticoagulant therapy was started and review of the therapy for these patients was performed. After surgery, anticoagulant therapy was performed on following patients with: ① undergoing surgery with lymph node dissection, ② BMI> 28, ③ a history of VTE, ④ thrombotic predisposition, ⑤ VTE discovered before onset of treatment. Patients other than ① to ⑤ received standard treatment. Patients who developed symptomatic VTE after surgery were repeatedly investigated and the prevention methods were improved based on the results. Recently the rate of patients who developed postoperative symptomatic VTE was decreased to about 0.3% (about 2.5% at the start of the study).
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Report
(5 results)
Research Products
(50 results)
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[Journal Article] Extended Clavien-Dindo classification of surgical complications: Japan Clinical Oncology Group postoperative complications criteria.2016
Author(s)
Katayama H, Kurokawa Y, Nakamura K, Ito H, Kanemitsu Y, Masuda N, Tsubosa Y, Satoh T, Yokomizo A, Fukuda H, Sasako M.
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Journal Title
Surg Today
Volume: 46(6)
Issue: 6
Pages: 668-685
DOI
NAID
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Clinicopathologic implications of DNA mismatch repair status in endometrial carcinomas.2016
Author(s)
Shikama A, Minaguchi T, Matsumoto K, Akiyama-Abe A, Nakamura Y, Michikami H, Nakao S, Sakurai M, Ochi H, Onuki M, Satoh T, Oki A, Yoshikawa H.
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Journal Title
Gynecol Oncol
Volume: 140(2)
Issue: 2
Pages: 226-233
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] HPV genotyping for triage of women with abnormal cervical cancer screening results: a multicenter prospective study2015
Author(s)
Yuko Nakamura, Koji Matsumoto, Toyomi Satoh, Ken Nishide, Akiko Nozue, Koji Shimabukuro, Seiichi Endo, Kimihiro Nagai, Akinori Oki, Hiroyuki Ochi, Yukio Morishita, Masayuki Noguchi, Hiroyuki Yoshikawa
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Journal Title
International Journal of Clinical Oncology
Volume: 印刷中
Issue: 5
Pages: 974-981
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Paclitaxel plus Carboplatin Versus Paclitaxel plus Cisplatin in Metastatic or Recurrent Cervical Cancer: The Open-Label Randomized Phase III Trial (JCOG0505),2015
Author(s)
Kitagawa R, Katsumata N, Shibata T, Kamura T, Kasamatsu T, Nakanishi T, Nishimura S, Ushijima K, Takano M, Satoh T, and Yoshikawa H.
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Journal Title
J Gynecol Oncol
Volume: 33(19)
Issue: 19
Pages: 2129-2135
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Optimizing biopsy procedures during colposcopy for women with abnormal cervical cancer screening results: a multicenter prospective study.2015
Author(s)
Nakamura Y, Matsumoto K, Satoh T, Nishide K, Nozue A, Shimabukuro K, Endo S, Nagai K, Oki A, Minaguchi T, Morishita Y, Noguchi M, Yoshikawa H.
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Journal Title
Int J Clin Oncol.
Volume: 20(3)
Issue: 3
Pages: 579-585
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Gynecologic Cancer Study Group of the Japan Clinical Oncology Group. A non-randomized confirmatory study regarding selection of fertility-sparing surgery for patients with epithelial ovarian cancer: Japan Clinical Oncology Group Study JCOG1203.2015
Author(s)
Satoh T, Tsuda H, Kanato K, Nakamura K, Shibata T, Takano M, Baba T, Ishikawa M, Ushijima K, Yaegashi N, Yoshikawa H
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Journal Title
Jpn J Clin Oncol
Volume: 45(6)
Issue: 6
Pages: 595-599
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Expression of Tissue Factor in Epithelial Ovarian Carcinoma Is Involved in the Development of Venous Thromboembolism2017
Author(s)
Wataru Takao, Manabu Sakurai, Masahiko Gosho, Akiko Sakata, Satoko, Sasaki, Ayumi Shikama, Nobutaka, Tasaka, Azusa Akiyama-Abe, Sari, Nakao, Hiroyuki Ochi, Takeo Minaguchi, Toyomi Satoh.
Organizer
25th Asian & Oceanic Congress of Obstetrics and Gynaecology (AOCOG)
Related Report
Int'l Joint Research
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[Presentation] Long-term follow-up of patients with an isolated ovarian recurrence after conservative treatment of epithelial ovarian cancer: Results of an international multicenter study comprising 545 patients.2015
Author(s)
Bentivegna E, Fruscio R, Roussin S, Ceppi L, Satoh T, Kajiyama H, Uzan C, Colombo N, Gouy S, Morice P.
Organizer
19th International Meeting of the European Society of Gynaecological Oncology (ESGO 2015)
Place of Presentation
Nice, (France)
Year and Date
2015-10-24
Related Report
Int'l Joint Research
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[Presentation] Long-term follow-up of patients with an isolated ovarian recurrence after conservative treatment of epithelial ovarian cancer: Results of an international multicenter study comprising 545 patients.2015
Author(s)
Morice P, Bentivegna E, Fruscio R, Satoh T, Kajiyama H, Roussin S, Uzan C, Colombo N, Gouy S.
Organizer
The European Cancer Congress 2015,
Place of Presentation
Vienna,( AUSTRIA)
Year and Date
2015-09-25
Related Report
Int'l Joint Research
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[Presentation] Optimal debulking surgery in patients with advanced uterine carcinosarcoma: A multi-institutional retrospective study from the Japanese Gynecologic Oncology Group.2015
Author(s)
Harano K, Hirakawa A, Yunokawa M, Nakamura T, Satoh T, Nishikawa T, Aoki D, Ito K, Ito K, Nakanishi T, Susumu N, Takehara K, Watanabe Y, Watari H, Saito T.
Organizer
Annual Meeting of the American Society of Clinical Oncology (ASCO),
Place of Presentation
Chicago, Illinois(USA)
Year and Date
2015-05-29
Related Report
Int'l Joint Research
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[Presentation] High pretreatment plasma D-dimer levels are associated with poor prognosis in patients with ovarian cancer independently of venous thromboembolism and tumour extension.2014
Author(s)
Sakurai M, Satoh T, Matsumoto K, Shikama A, Michikami H, Tasaka Y, Nakamura Y, Nakao S, Ochi H, Onuki M, Minaguchi T, Yoshikawa H.
Organizer
The 15th Biennial Meeting of the International Gynecologic Cancer Society
Place of Presentation
Melbourne, Australia
Year and Date
2014-11-08 – 2014-11-11
Related Report
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