Development of novel molecular targeted therapies, inducing apoptotic cell death, in endometrial and ovarican carcinomas

• Project/Area Number: 26462515
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: The University of Tokyo
• Principal Investigator: Oda Katsutoshi 東京大学, 医学部附属病院, 准教授 (30359608)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 子宮体癌 / 卵巣癌 / 分子標的治療 / ゲノム解析 / バイオマーカー / PI3K / MDM2 / TP53 / 分子標的薬 / 卵巣明細胞癌 / ユビキチン・プロテアソーム / PI3K経路 / HIF-1alpha / アポトーシス / 放射線感受性 / オートファジー / クロロキン / シスプラチン耐性

Outline of Final Research Achievements

We identified molecular subtypes and candidate molecular-targeted therapies in endometrial and ovarian (mainly clear cell histology) cancers. Furthermore, we revealed their anti-tumor effects in these cancers.
1. We found that either a MAPK inhibitor or ionizing radiation synergistically enhanced anti-tumor effect by a PI3K pathway inhibitor (dual PI3K/mTOR inhibitor) in endometrial cancer cells. We showed that HIF-1alpha/VEGF pathway plays an essential role in the cell proliferation of endometrial cancer cells and that HIF-1alpha/VEGF activity is dependent on activation of the PI3K/mTOR pathway.
2. We revealed a poor prognostic subgroup in ovarian clear cell carcinomas, using genome-wide analyses, including single nucleotide polymorphism arrays and expression arrays. We reported that over-expression of MDM2 is associated with poor prognosis and that inhibiting MDM2 showed anti-tumor effect in ovarian clear cell carcinoma cells.

Research Products

• [Journal Article] Oncogenic histone methyltransferase EZH2: A novel prognostic marker with therapeutic potential in endometrial cancer (2017)
  • Author(s): Oki S, Sone K, Oda K, Hamamoto R, Ikemura M, Maeda D, Takeuchi M, Tanikawa M, Mori-Uchino M, Nagasaka K, Miyasaka A, Kashiyama T, Ikeda Y, Arimoto T, Kuramoto H, Wada-Hiraike O, Kawana K, Fukayama M, Osuga Y, Fujii T.
  • Journal Title: Oncotarget Volume: 8 Issue: 25 Pages: 40402
  • DOI: 10.18632/oncotarget.16316
  • NAID: 120007089062
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] MDM2 is a potential therapeutic target and prognostic factor for ovarian clear cell carcinomas with wild type TP53. (2016)
  • Author(s): Makii C, Oda K, Ikeda Y, Sone K, Hasegawa K, Uehara Y, Nishijima A, Asada K, Koso T, Fukuda T, Inaba K, Oki S, Machino H, Kojima M, Kashiyama T, Mori-Uchino M, Arimoto T, Wada-Hiraike O, Yano KK, Fujiwara K, Aburatani H, Osuga Y, Fujii T.
  • Journal Title: Oncotarget Volume: 7 Issue: 46 Pages: 75328-75338
  • DOI: 10.18632/oncotarget.12175
  • Peer Reviewed / Open Access
• [Journal Article] Synergistic antitumor effects of combination of PI3K/mTOR and MEK inhibition (SAR245409 and pimasertib) in mucinous ovarian carcinoma cells by fluorescence resonance energy transfer imaging. (2016)
  • Author(s): Inaba K, Oda K, Aoki K, Sone K, Ikeda Y, Miyasaka A, Kashiyama T, Fukuda T, Makii C, Arimoto T, Wada-Hiraike O, Kawana K, Yano T, Osuga Y, Fujii T
  • Journal Title: Oncotarget Volume: 7 Issue: 20 Pages: 29577-29591
  • DOI: 10.18632/oncotarget.8807
  • NAID: 120005820854
  • Peer Reviewed / Open Access
• [Journal Article] Significance of survivin as a prognostic factor and a therapeutic target in endometrial cancer. (2016)
  • Author(s): Chuwa AH, Sone K, Oda K, Ikeda Y, Fukuda T, Wada-Hiraike O, Inaba K, Makii C, Takeuchi M, Oki S, Miyasaka A, Kashiyama T, Arimoto T, Kuramoto H, Kawana K, Yano T, Osuga Y, Fujii T.
  • Journal Title: Gynecol Oncol Volume: 141 Issue: 3 Pages: 564-569
  • DOI: 10.1016/j.ygyno.2016.04.003
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Autophagy inhibition augments resveratrol-induced apoptosis in Ishikawa endometrial cancer cells. (2016)
  • Author(s): Fukuda T, Oda K, Wada-Hiraike O, Sone K, Inaba K, Ikeda Y, Makii C, Miyasaka A, Kashiyama T, Tanikawa M, Arimoto T, Yano T, Kawana K, Osuga Y, Fujii T.
  • Journal Title: Oncol Lett Volume: 12 Issue: 4 Pages: 2560-2566
  • DOI: 10.3892/ol.2016.4978
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A case of lymphangioleiomyomatosis associated with endometrial cancer and severe systemic lupus erythematosus (2016)
  • Author(s): Suzuki K, Nagasaka K, ORCID: httporcidorg0000000206965175, Oda K, Abe H, Maeda D, Matsumoto Y, Arimoto T, Kawana K, Fukayama M, Osuga Y, Fujii T.
  • Journal Title: BMC Cancer Volume: 16 Issue: 1 Pages: 1-5
  • DOI: 10.1186/s12885-016-2413-z
  • NAID: 120007089067
  • Peer Reviewed / Open Access
• [Journal Article] Characterization of TP53 and PI3K signaling pathways as molecular targets in gynecologic malignancies. (2016)
  • Author(s): Oda K, Ikeda Y, Kashiyama T, Miyasaka A, Inaba K, Fukuda T, Asada K, Sone K, Wada-Hiraike O, Kawana K, Osuga Y, Fujii T
  • Journal Title: J Obstet Gynaecol Res Volume: in press
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Perspectives on targeting the phosphatidylinositol 3-kinase pathway for personalized medicine in endometrial and ovarian cancers. (2016)
  • Author(s): Oda K, Ikeda Y, Kashiyama T, Miyasaka A, Inaba K, Miyamoto Y, Wada-Hiraike O, Kawana K, Osuga Y, Fujii T
  • Journal Title: Personalized Medicine Universe Volume: in press
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Risk of endometrial cancer in patients with a preoperative diagnosis of atypical endometrial hyperplasia treated with total laparoscopic hysterectomy (2016)
  • Author(s): Oda K, Koga K, Hirata T, Maruyama M, Ikemura M, Matsumoto Y, Nagasaka K, Adachi K, Mori-Uchino M, Sone K, Arimoto T, Wada-Hiraike O, Kawana K, Fukayama M, Fujii T, Osuga Y
  • Journal Title: Gynecol Minim Invasive Ther Volume: 5 Issue: 2 Pages: 69
  • DOI: 10.1016/j.gmit.2016.02.001
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] A case of successful detection of disseminated gastrointestinal stromal tumors by ascites smear cytology using cell block preparation with DOG1 immunostaining (2016)
  • Author(s): Tajima S, Kawabe A, Nagasaka K, Oda K, Kawana K, Fukayama M
  • Journal Title: Diagn Cytopathol Volume: 44 Issue: 2 Pages: 137
  • DOI: 10.1002/dc.23395
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Radical hysterectomy with or without para-aortic lymphadenectomy for patients with stage IB2, IIA2, and IIB cervical cancer: outcomes for a series of 308 patients (2016)
  • Author(s): Tsuruga T, Fujimoto A, Kawana K, Mori M, Hasumi Y, Kino N, Tomio K, Miura S, Tanikawa M, Sone K, Miyamoto Y, Ikeda Y, Kojima S, Adachi K, Nagasaka K, Matsumoto Y, Arimoto T, Oda K, Nakagawa S, Horie K, Yasugi T, Yokota H, Osuga Y, Fujii T
  • Journal Title: Int J Clin Oncol Volume: 21 Issue: 2 Pages: 359
  • DOI: 10.1007/s10147-015-0907-3
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Vaginal cancer possibly caused by pessary and immunocompromised condition: Multiple risk factors may influence vaginal cancer development. (2016)
  • Author(s): Akino N, Wada-Hiraike O, Matsumoto Y, Arimoto T, Oda K, Kawana K, Osuga Y, Fujii T
  • Journal Title: J Obstet Gynaecol Res Volume: in press Issue: 6 Pages: 748-751
  • DOI: 10.1111/jog.12958
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Enhanced efficacy against cervical carcinomas through polymeric micelles physically incorporating the proteasome inhibitor MG132 (2016)
  • Author(s): Matsumoto Y, Miyamoto Y, Cabral H, Matsumoto Y, Nagasaka K, Nakagawa S, Yano T, Maeda D, Oda K, Kawana K, Nishiyama N, Kataoka K, Fujii T
  • Journal Title: Cancer Sci Volume: 107 Issue: 6 Pages: 773
  • DOI: 10.1111/cas.12926
  • NAID: 120007089072
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Systemic delivery of siRNA by actively targeted polyion complex micelles for silencing the E6 and E7 human papillomavirus oncogenes. (2016)
  • Author(s): Nishida H, Matsumoto Y, Kawana K, Christie RJ, Naito M, Kim BS, Toh K, Min HS, Yi Y, Matsumoto Y, Kim HJ, Miyata K, Taguchi A, Tomio K, Yamashita A, Inoue T, Nakamura H, Fujimoto A, Sato M, Yoshida M, Adachi K, Arimoto T, Wada-Hiraike O, Oda K, Nagamatsu T, Nishiyama N, Kataoka K, Osuga Y, Fujii T
  • Journal Title: J Control Release Volume: in press
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Molecular Characterization and Identification of Molecular Targets in Endometrial Cancer and Ovarian Clear Cell Carcinoma (2015)
  • Author(s): Oda K
  • Journal Title: ACTA OBST GYNAEC JPN Volume: 67 Pages: 1614-1625
  • NAID: 110009969949
• [Journal Article] The anti-malarial chloroquine suppresses proliferation and overcomes cisplatin resistance of endometrial cancer cells via autophagy inhibition. (2015)
  • Author(s): Fukuda T, Oda K, Wada-Hiraike O, Sone K, Inaba K, Ikeda Y, Miyasaka A, Kashiyama T, Tanikawa M, Arimoto T, Kuramoto H, Yano T, Kawana K, Osuga Y, Fujii T.
  • Journal Title: Gynecol Oncol Volume: 137 Issue: 3 Pages: 538-545
  • DOI: 10.1016/j.ygyno.2015.03.053
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] PI3K/mTOR pathway inhibition overcomes radioresistance via suppression of the HIF1-α/VEGF pathway in endometrial cancer. (2015)
  • Author(s): Miyasaka A, Oda K, Ikeda Y, Sone K, Fukuda T, Inaba K, Makii C, Enomoto A, Hosoya N, Tanikawa M, Uehara Y, Arimoto T, Kuramoto H, Wada-Hiraike O, Miyagawa K, Yano T, Kawana K, Osuga Y, Fujii T.
  • Journal Title: Gynecol Oncol Volume: 138 Issue: 1 Pages: 174-180
  • DOI: 10.1016/j.ygyno.2015.04.015
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Antitumor activity of a combination of dual PI3K/mTOR inhibitor SAR245409 and selective MEK1/2 inhibitor pimasertib in endometrial carcinomas. (2015)
  • Author(s): Inaba K, Oda K, Ikeda Y, Sone K, Miyasaka A, Kashiyama T, Fukuda T, Uehara Y, Arimoto T, Kuramoto H, Wada-Hiraike O, Kawana K, Yano T, Osuga Y, Fujii T.
  • Journal Title: Gynecol Oncol Volume: 138 Issue: 2 Pages: 323-331
  • DOI: 10.1016/j.ygyno.2015.05.031
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Integrated copy number and expression analysis identifies profiles of whole-arm chromosomal alterations and subgroups with favorable outcome in ovarian clear cell carcinomas. (2015)
  • Author(s): Uehara Y, Oda K, Ikeda Y, Koso T, Tsuji S, Yamamoto S, Asada K, Sone K, Kurikawa R, Makii C, Hagiwara O, Tanikawa M, Maeda D, Hasegawa K, Nakagawa S, Wada-Hiraike O, Kawana K, Fukayama M, Fujiwara K, Yano T, Osuga Y, Fujii T, Aburatani H
  • Journal Title: PLoS One Volume: 10 Issue: 7 Pages: e0132751-e0132751
  • DOI: 10.1371/journal.pone.0132751
  • NAID: 120007089049
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Prognostic importance of CDK4/6-specific activity as a predictive marker for recurrence in patients with endometrial cancer, with or without adjuvant chemotherapy. (2015)
  • Author(s): keda Y, Oda K, Ishihara H, Wada-Hiraike O, Miyasaka A, Kashiyama T, Inaba K, Fukuda T, Sone K, Matsumoto Y, Arimoto T, Maeda D, Ikemura M, Fukayama M, Kawana K, Yano T, Aoki D, Osuga Y, Fujii T.
  • Journal Title: Br J Cancer Volume: 113 Issue: 10 Pages: 1477-1483
  • DOI: 10.1038/bjc.2015.369
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Putative tumor suppression function of SIRT6 in endometrial cancer. (2015)
  • Author(s): Fukuda T, Wada-Hiraike O, Oda K, Tanikawa M, Makii C, Inaba K, Miyasaka A, Miyamoto Y, Yano T, Maeda D, Sasaki T, Kawana K, Fukayama M, Osuga Y, Fujii T.
  • Journal Title: FEBS Lett Volume: 589 Issue: 17 Pages: 2274-2281
  • DOI: 10.1016/j.febslet.2015.06.043
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Minimization of curative surgery for treatment of early cervical cancer: A review (2015)
  • Author(s): Arimoto T, Kawana K, Adachi K, Ikeda Y, Nagasaka K, Tsuruga T, Yamashita A, Oda K, Ishikawa M, Kasamatsu T, Onda T, Konishi I, Yoshikawa H, Yaegashi N
  • Journal Title: Jpn J Clin Oncol Volume: 45 Issue: 7 Pages: 611
  • DOI: 10.1093/jjco/hyv048
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] HAND2-mediated proteolysis negatively regulates the function of estrogen receptor α (2015)
  • Author(s): Fukuda T, Shirane A, Wada-Hiraike O, Oda K, Tanikawa M, Sakuabashi A, Hirano M, Fu H, Morita Y, Miyamoto Y, Inaba K, Kawana K, Osuga Y, Fujii T.
  • Journal Title: Mol Med Rep Volume: 12 Issue: 4 Pages: 5538
  • DOI: 10.3892/mmr.2015.4070
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] The Risk of Ovarian Malignancy Algorithm (ROMA) as a Predictive Marker of Peritoneal Dissemination in Epithelial Ovarian Cancer Patients. (2015)
  • Author(s): Ikeda Y, Hasegawa K, Kurosaki A, Miyara A, Hanaoka T, Shintani D, Imai Y, Nishikawa T, Oda K, Fujiwara K
  • Journal Title: Oncol Res Treat Volume: 38 Issue: 6 Pages: 276-281
  • DOI: 10.1159/000430858
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] CCAR2 negatively regulates nuclear receptor LXRα by competing with SIRT1 deacetylase (2015)
  • Author(s): Sakurabashi A, Wada-Hiraike O, Hirano M, Fu H, Isono W, Fukuda T, Morita Y, Tanikawa M, Miyamoto Y, Oda K, Kawana K, Osuga Y, Fujii T.
  • Journal Title: J Steroid Biochem Mol Biol Volume: 149 Pages: 80
  • DOI: 10.1016/j.jsbmb.2015.02.001
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] HPV-16 impairs the subcellular distribution and levels of expression of protein phosphatase 1γ in cervical malignancy (2015)
  • Author(s): Seiki T, Nagasaka K, Kranjec C, Kawana K, Maeda D, Nakamura H, Taguchi A, Matsumoto Y, Arimoto T, Wada-Hiraike O, Oda K, Nakagawa S, Yano T, Fukayama M, Banks L, Osuga Y, Fujii T.
  • Journal Title: BMC Cancer Volume: 15 Issue: 1 Pages: 230-230
  • DOI: 10.1186/s12885-015-1141-0
  • NAID: 120007089068
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Clinical significance of Gremlin 1 in cervical cancer and its effects on cancer stem cell maintenance (2015)
  • Author(s): Sato M, Kawana K, Fujimoto A, Yoshida M, Nakamura H, Nishida H, Inoue T, Taguchi A, Takahashi J, Adachi K, Nagasaka K, Matsumoto Y, Wada-Hiraike O, Oda K, Osuga Y, Fujii T.
  • Journal Title: Oncol Rep Volume: 35 Issue: 1 Pages: 391
  • DOI: 10.3892/or.2015.4367
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] 【婦人科悪性腫瘍治療に対するドラッグリポジショニングの幕開け-既存薬に秘められた新たな可能性】 卵巣癌新規治療薬候補PI3K/mTOR阻害薬DS-7423によるTP53依存性アポトーシス誘導能の活性化 (2015)
  • Author(s): 織田 克利、樫山 智子
  • Journal Title: 産科と婦人科 Volume: 82 Pages: 1113-1118
• [Journal Article] 子宮体癌・卵巣明細胞腺癌における分子生物学的特性と治療標的経路の解明 (2015)
  • Author(s): 織田 克利
  • Journal Title: 日本産科婦人科学会雑誌 Volume: 67 Pages: 1614-1625
• [Journal Article] mTOR Signaling in Endometrial Cancer: From a Molecular and Therapeutic Point of View (2015)
  • Author(s): Oda K, Ikeda Y, Kawana K, Osuga Y, Fujii T
  • Journal Title: Curr Obstet Gynecol Rep Volume: 4 Issue: 1 Pages: 1-10
  • DOI: 10.1007/s13669-014-0103-x
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Recent process of molecular target therapies in ovarian serous and endometrioid carcinomas on basis of intergrated genomic characterization (2015)
  • Author(s): Oda K
  • Journal Title: Gan To Kagaku Ryoho Volume: 42 Pages: 169-173
• [Journal Article] Characterization of novel transcripts of human papillomavirus type 16 using cap analysis gene expression technology (2015)
  • Author(s): Taguchi A, Nagasaka K, Kawana K, Hashimoto K, Kusumoto-Matsuo R, Plessy C, Miranda T, Nakamura H, Bonetti A, Oda K, Kukimoto I, Carninci P, Banks L, Osuga Y, Fujii T,
  • Journal Title: J Virol Volume: 89 Issue: 4 Pages: 2448
  • DOI: 10.1128/jvi.03433-14
  • Peer Reviewed / Open Access
• [Journal Article] よくわかる検査と診断 がん関連遺伝子検査 (2015)
  • Author(s): 織田 克利
  • Journal Title: 診断と治療社 産科と婦人科 Volume: 82
• [Journal Article] Positive peritoneal cytology at interval surgery is a poor prognostic factor in patients with stage T3c advanced ovarian carcinoma: A retrospective study (2014)
  • Author(s): Nagasaka K, Kawana K, Tomio K, Eguchi S, Miura S, Tsuruga T, Mori-Uchino M, Tanikawa M, Tsukazaki T, Sone K, Adachi K, Matsumoto Y, Arimoto T, Oda K, Osuga Y, Fujii T
  • Journal Title: J Obstet Gynecol Res Volume: 41 Issue: 5 Pages: 755
  • DOI: 10.1111/jog.12616
  • Peer Reviewed
• [Journal Article] Huge pyogenic cervical cyst with endometriosis, developing 13 years after myomectomy at the lower uterine segment: a case report. (2014)
  • Author(s): Oda K, Ikeda Y, Maeda D, Arimoto T, Kawana K, Fukayama M, Osuga Y, Fujii T
  • Journal Title: BMC Womens Health Volume: 14 Issue: 1 Pages: 104-104
  • DOI: 10.1186/1472-6874-14-104
  • NAID: 120007089070
  • Peer Reviewed / Open Access
• [Journal Article] Non-diethylstilbestrol exposed vaginal clear cell adenocarcinoma has a common molecular profile with ovarian clear cell adenocarcinoma: A case report (2014)
  • Author(s): Ikeda Y, Oda K, Aburatani H, Kawana K, Osuga Y, Fujii T
  • Journal Title: Gynecol Oncol Rep Volume: 10 Pages: 49-52
  • DOI: 10.1016/j.gynor.2014.05.006
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Xanthogranulomatous inflammation of the perimetrium with infiltration into the uterine myometrium in a postmenopausal woman: a case report. (2014)
  • Author(s): Inoue T, Oda K, Arimoto T, Samejima T, Takazawa Y, Maeda D, Fukayama M, Kawana K, Osuga Y, Fujii T.
  • Journal Title: BMC Womens Health Volume: 14 Issue: 1 Pages: 82-82
  • DOI: 10.1186/1472-6874-14-82
  • NAID: 120007089071
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] SIRT3 positively regulates the expression of folliculogenesis- and luteinization-related genes and progesterone secretion by manipulating oxidative stress in human luteinized granulosa cells (2014)
  • Author(s): Fu H, Wada-Hiraike O, Hirano M, Kawamura Y, Sakurabashi A, Shirane A, Morita Y, Isono W, Oishi H, Koga K, Oda K, Kawana K, Yano T, Kurihara H, Osuga Y, Fujii T.
  • Journal Title: Endocrinology Volume: 155 Issue: 8 Pages: 3079
  • DOI: 10.1210/en.2014-1025
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Oral vaccination against HPV E7 for treatment of cervical intraepithelial neoplasia grade 3 (CIN3) elicits E7-specific mucosal immunity in the cervix of CIN3 patients (2014)
  • Author(s): Kawana K, Adachi K, Kojima S, Taguchi A, Tomio K, Yamashita A, Nishida H, Nagasaka K, Arimoto T, Yokoyama T, Wada-Hiraike O, Oda K, Sewaki T, Osuga Y, Fujii T
  • Journal Title: Vaccine Volume: 32 Issue: 47 Pages: 6233
  • DOI: 10.1016/j.vaccine.2014.09.020
  • Peer Reviewed
• [Journal Article] 子宮体癌細胞株におけるPTEN発現とPARP阻害剤/放射線への感受性 (2014)
  • Author(s): 宮坂 亞希, 織田 克利
  • Journal Title: 放射線生物研究 Volume: 49 Pages: 410-417
  • NAID: 40020314361
  • Peer Reviewed
• [Journal Article] 卵巣がんと子宮体がんにおけるゲノム解読 (2014)
  • Author(s): 織田 克利
  • Journal Title: 実験医学 Volume: 32 Pages: 1885-1892
• [Presentation] 卵巣がんのゲノム解析と分子標的治療の将来 (2016)
  • Author(s): 織田克利
  • Organizer: 第2回日本産科婦人科遺伝診療学会学術講演会
  • Place of Presentation: 京都
  • Year and Date: 2016-12-16
  • Invited
• [Presentation] 子宮内膜異形増殖症またはAPAMの術前診断における子宮鏡下手術(TCR)の有用性の検討 (2016)
  • Author(s): 織田克利、長阪一憲、甲賀かをり、平田哲也、池村雅子、松本陽子、丸山正統、森繭代、足立克之、有本貴英、平池修、川名敬、深山正久、大須賀穣、藤井知行
  • Organizer: 第54回日本癌治療学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2016-10-20
• [Presentation] The number of mutations and mutational signatures in ovarian high-grade serous carcinomas (2016)
  • Author(s): Katsutoshi Oda, Kayo Asada, Kosei Hasegawa, Akira Nishijima, Shogo Yamamoto, Kenji Tatsuno, Hiroki Ueda, Yuji Ikeda, Kei Kawana, Keiichi Fujiwara, Yutaka Osuga, Tomoyuki Fujii, Hiroyuki Aburatani
  • Organizer: 第75回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2016-10-06
• [Presentation] 卵巣癌における治療標的と個別化への展望～PARP阻害剤、MDM2阻害剤、MAPK経路阻害剤を中心に～ (2016)
  • Author(s): 織田克利、長谷川幸清、池田悠至、曾根献文、谷川道洋、牧井千波、浅田佳代、西島明、黒崎亮、山本尚吾、平池修、川名敬、藤原恵一、油谷浩幸、大須賀穣、藤井知行
  • Organizer: 第48回 日本臨床分子形態学会総会・学術集会
  • Place of Presentation: 熊本
  • Year and Date: 2016-09-23
  • Invited
• [Presentation] 子宮内膜異型増殖症の術前診断で腹腔鏡下子宮全摘術を施行した症例における子宮体癌のリスク予測因子の検討 (2016)
  • Author(s): 織田克利、甲賀かをり、平田哲也、丸山正統、池村雅子、松本陽子、長阪一憲、足立克之、森繭代、曾根献文、有本貴英、平池修、川名敬、深山正久、大須賀穣、藤井知行
  • Organizer: 第56回日本産科婦人科内視鏡学会学術講演会
  • Place of Presentation: 長崎
  • Year and Date: 2016-09-01
• [Presentation] Molecular-targeted therapies and genomic characterization in gynecologic cancers (2016)
  • Author(s): Katsutoshi Oda
  • Organizer: 第14回日本臨床腫瘍学会学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2016-07-28
  • Invited
• [Presentation] Molecular-targeted therapies and potential biomarkers for ovarian cancer (2016)
  • Author(s): 織田克利
  • Organizer: 第58回日本婦人科腫瘍学会学術講演会
  • Place of Presentation: 米子
  • Year and Date: 2016-07-08
  • Invited
• [Presentation] 卵巣明細胞腺癌75例における全エクソン解析を含む統合的ゲノム解析 (2016)
  • Author(s): 西島明、織田克利、長谷川幸清、曾根献文、神尊貴裕、浅田佳代、山本尚吾、上田宏樹 、辰野健二、池田悠至、上原ゆり子、谷川道洋、藤原恵一、平池修、川名敬、大須賀穣、藤井知行、油谷浩幸
  • Organizer: 第58回日本婦人科腫瘍学会学術講演会
  • Place of Presentation: 米子
  • Year and Date: 2016-07-08
• [Presentation] 子宮内膜異型増殖症の診断で鏡視下手術を施行した症例における術前内膜細胞診所見 (2016)
  • Author(s): 織田克利、松本陽子、長阪一憲、足立克之、池村雅子、有本貴英、川名敬、深山正久、大須賀穣、藤井知行
  • Organizer: 第 57 回日本臨床細胞学会総会（春期大会) 学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2016-05-28
• [Presentation] Combination of MDM2 inhibitor and PI3K/mTOR inhibitor showed synergistic anti-tumor effect in ovarian clear cell carcinomas (2016)
  • Author(s): Chinami Makii, Katsutoshi Oda, Kenbun Sone, Tomoko Kashiyama, Kayo Asada, Makoto Takeuchi, Shinya Oki, Akira Nishijima, Osamu Wada-Hiraike, Kei Kawana, Yutaka Osuga, Tomoyuki Fujii
  • Organizer: 第68回日本産科婦人科学会学術講演会
  • Place of Presentation: 東京
  • Year and Date: 2016-04-21
• [Presentation] Anti-tumor effect of inhibition of DNA damage response proteins, ATM and ATR, in endometrial cancer cells (2016)
  • Author(s): Makoto Takeuchi, Katsutoshi Oda, Kenbun Sone, Chinami Makii, Agapiti Chuwa, Shinya Oki, Aki Miyasaka, Hiroyuki Kuramoto, Osamu Wada-Hiraike, Kei Kanana, Yutaka Osuga, Tomoyuki Fujii
  • Organizer: 第68回日本産科婦人科学会学術講演会
  • Place of Presentation: 東京
  • Year and Date: 2016-04-21
• [Presentation] Number of somatic mutations by whole-exome sequencing is associated with both surgical outcome and chemosensitivity in high-grade ovarian serous carcinoma (2016)
  • Author(s): Kayo Asada, Katsutoshi Oda, Kosei Hasegawa, Akira Nishijima, Akira Kurosaki, Aki Miyasaka, Yuji Ikeda, Kei Kawana, Tetsu Yano, Keiichi Fujiwara, Yutaka Osuga, Tomoyuki Fujii
  • Organizer: 第68回日本産科婦人科学会学術講演会
  • Place of Presentation: 東京
  • Year and Date: 2016-04-21
• [Presentation] The histone methyltransferase EZH2 is a novel target of anticancer therapy in endometrial cancer (2016)
  • Author(s): SHINYA OKI, KENBUN SONE, KATSUTOSHI ODA, AKIRA NISHIJIMA, MAKOTO TAKEUCHI, CHUWA AGAPITI, KAYO ASADA, CHINAMI MAKII, KEI KAWANA, YUTAKA OSUGA and TOMOYUKI FUJII.
  • Organizer: AACR 107th Annual Meeting 2016
  • Place of Presentation: New Orleans, LA, USA
  • Year and Date: 2016-04-16
  • Int'l Joint Research
• [Presentation] 女性とがん_~女性のライフサイクルにおける婦人科・その他のがんのお話! (2016)
  • Author(s): 織田克利
  • Organizer: 文京区医師会 第18回女性健康セミナー
  • Place of Presentation: 東京
  • Year and Date: 2016-01-23
  • Invited
• [Presentation] 卵巣癌の診断・治療における最近の動向 ～個別化治療は進むのか？～ (2016)
  • Author(s): 織田克利
  • Organizer: 北関東婦人科化学療法講演会2016
  • Place of Presentation: 東京
  • Invited
• [Presentation] 第18回神澤医学賞受賞講演 婦人科悪性腫瘍における包括的ゲノムプロファイルの解明と個別化治療法の開発 (2016)
  • Author(s): 織田克利
  • Organizer: 公益財団法人 神澤医学研究振興財団 第18回講演会
  • Place of Presentation: 東京
  • Invited
• [Presentation] 子宮鏡下手術を施行し確定診断に至った子宮内膜悪性病変症例の後方視的検討 (2015)
  • Author(s): 長阪 一憲、松本 陽子、織田 克利、丸山 正統、山下 亜紀、曾根 献文、森 繭代、足立 克之、平池 修、川名 敬、大須賀 穣、藤井 知行
  • Organizer: 第54回日本臨床細胞学会総会秋期大会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-11-21
• [Presentation] 卵巣癌の診断・治療における最近の動向_～個別化治療は進むのか？ (2015)
  • Author(s): 織田克利
  • Organizer: 第412回神奈川産科婦人科学会学術講演会 教育セミナー
  • Place of Presentation: 神奈川
  • Year and Date: 2015-11-14
  • Invited
• [Presentation] 子宮体癌における分子標的治療法への期待_～RAS/PI3K経路を中心に～ (2015)
  • Author(s): 織田 克利
  • Organizer: 【第6回金沢大学学際科学実験センターシンポジウム】 女性生殖組織の機能と疾患
  • Place of Presentation: 金沢
  • Year and Date: 2015-11-13
  • Invited
• [Presentation] Molecular Biology of low-grade serous carcinomas (2015)
  • Author(s): Oda K
  • Organizer: Gynecologic Cancer Intergroup: Ovarian Rare Tumors Conference
  • Place of Presentation: 東京
  • Year and Date: 2015-11-06
  • Int'l Joint Research / Invited
• [Presentation] 子宮体癌のゲノム多様性と個別化治療 子宮体癌のシグナル解析と分子標的治療への期待 (2015)
  • Author(s): 織田 克利、曾根 献文、池田 悠至、宮坂 亞希、福田 友彦、稲葉 可奈子、牧井 千波、藏本 博行、平池 修、川名 敬、大須賀 穣、藤井 知行
  • Organizer: 第53回日本癌治療学会学術集会 臓器別シンポジウム11 子宮体癌のゲノム多様性と個別化治療
  • Place of Presentation: 京都
  • Year and Date: 2015-10-29
  • Invited
• [Presentation] 行卵巣癌に対するベバシズマブ療法の至適使用および安全性に関する後方視的検討 (2015)
  • Author(s): 長阪 一憲、織田 克利、田中 智基、田口 歩、山下 亜紀、曾根 献文、森 繭代、足立 克之、有本 貴英、川名 敬、大須賀 穣、藤井 知行
  • Organizer: 第53回日本癌治療学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2015-10-29
• [Presentation] 卵巣がんトランスレーショナル・リサーチ 新たな実験手法～FRET法～を用いた卵巣粘液性腺癌における分子標的薬併用療法の検討 (2015)
  • Author(s): 稲葉 可奈子、織田 克利、青木 一洋、曾根 献文、宮坂 亞希、樫山 智子、福田 友彦、牧井 千波、池田 悠至、平池 修、川名 敬、大須賀 穣、藤井 知行
  • Organizer: 第53回日本癌治療学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2015-10-29
• [Presentation] Cell free DNA and ascites might reflect tumor heterogeneity in ovarian carcinomas (2015)
  • Author(s): 浅田 佳代、織田 克利、西島 明、萩原 吟重、山本 尚吾、辰野 健二、上田 宏樹、長谷川 幸清、藤原 恵一、川名 敬、大須賀 譲、藤井 知行、油谷 浩幸
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-10-08
• [Presentation] Anti-tumor effect of RG-7112, an inhibitor of p53-MDM2 interaction, in ovarian clear cell adenocarcinomas (2015)
  • Author(s): 牧井 千波、織田 克利、曾根 献文、樫山 智子、宮坂 亞希、稲葉 可奈子、福田 友彦、浅田 佳代, Chuwa Agapiti、平池 修、川名 敬、大須賀 穣、藤井 知行
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-10-08
• [Presentation] Identification of prognostic factors by whole-exome sequencing in 83 cases of high-grade serous ovarian adenocarcinomas (2015)
  • Author(s): 西島 明、織田 克利、浅田 佳代、山本 尚吾、辰野 健二、上田 宏樹、長谷川 幸清、藤原 恵一、川名 敬、矢野 哲、大須賀 穣、藤井 知行、油谷 浩幸
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-10-08
• [Presentation] SIRT6 is a possible tumor suppressor of endometrial cancer (2015)
  • Author(s): 福田 友彦、平池 修、織田 克利、曾根 献文、稲葉 可奈子、宮坂 亞希、前田 大地、佐々木 毅、矢野 哲、川名 敬、深山 正久、大須賀 穣、藤井 知行
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-10-08
• [Presentation] 子宮頸癌と子宮体癌 ～最近の動向～ (2015)
  • Author(s): 織田克利
  • Organizer: 第２４回 東京大学医師会 生涯教育講演会
  • Place of Presentation: 東京
  • Year and Date: 2015-09-26
  • Invited
• [Presentation] 教育プログラムB がんの生物学・遺伝学と分子標的治療 (2015)
  • Author(s): 織田 克利
  • Organizer: 第57回日本婦人科腫瘍学会学術講演会
  • Place of Presentation: 盛岡
  • Year and Date: 2015-08-07
  • Invited
• [Presentation] SIRT6は子宮体癌に対して癌抑制的作用を持つ (2015)
  • Author(s): 福田友彦、平池修、織田克利、曾根献文、池田悠至、樫山智子、宮坂亜希、稲葉可奈子、牧井千波、前田大地、川名敬、佐々木毅、大須賀穣、深山正久、藤井知行
  • Organizer: 第14回日本婦人科がん分子標的研究会
  • Place of Presentation: 松本
  • Year and Date: 2015-07-18
• [Presentation] 卵巣明細胞腺癌におけるp53-MDM2結合阻害剤RG7112による抗腫瘍効果の検討 (2015)
  • Author(s): 牧井千波、織田克利、曾根献文、池田悠至、樫山智子、宮坂亞希、福田友彦、稲葉可奈子, Agapiti Chuwa、浅田佳代、竹内真、平池修、川名敬、大須賀穣、藤井知行
  • Organizer: 第14回日本婦人科がん分子標的研究会
  • Place of Presentation: 松本
  • Year and Date: 2015-07-18
• [Presentation] 全エクソンシークエンス解析を用いた_卵巣がんにおける遺伝子変異の同定 (2015)
  • Author(s): 織田 克利
  • Organizer: AMED・次世代がん研究シーズ 戦略的育成プログラム がん臨床シーズ育成領域・公開シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2015-06-29
  • Invited
• [Presentation] 卵巣癌と子宮体癌における個別化治療の展望 PI3K経路とTP53経路を中心に (2015)
  • Author(s): 織田 克利
  • Organizer: 第20回国際個別化医療学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2015-05-24
  • Invited
• [Presentation] Tumor heterogeneity covered by circulating tumor DNA from blood sample (2015)
  • Author(s): Kayo Asada, Katsutoshi Oda, Kengo Goto, Shogo Yamamoto, Kenji Tatsuno, Hiroki Ueda, Yuji Ikeda, Kei Kawana, Tetsu Yano, Yutaka Osuga, Tomoyuki Fujii, Hiroyuki Aburatani
  • Organizer: The 11th International Workshop on Advanced Genomics
  • Place of Presentation: 東京
  • Year and Date: 2015-05-21
  • Int'l Joint Research
• [Presentation] The anti-tumor effect of antimalarial chloroquine on endometrial cancer cells is dependent on autophagy inhibition (2015)
  • Author(s): Tomohiko Fukuda, Katsutoshi Oda, Osamu Wada-Hiraike, Kenbun Sone, Kanako Inaba, Yuji Ikeda, Tomoko Kashiyama, Aki Miyasaka, Chinami Makii, Reiko Kurikawa, Takahide Arimoto, Tetsu Yano, Kei Kawana, Noboru Mizushima, Yutaka Osuga, and Tomoyuki Fujii
  • Organizer: AACR 106th Annual Meeting 2015
  • Place of Presentation: Philadelphia, PA
  • Year and Date: 2015-04-18
  • Int'l Joint Research
• [Presentation] Identification of genetic heterogeneity by whole exome sequencing using cell free DNA from blood samples (2015)
  • Author(s): Kayo Asada, Katsutoshi Oda, Kengo Gotoh, Reiko Kurikawa, Shogo Yamamoto, Kenji Tatsuno, Hiroki Ueda, Yuji Ikeda, Yuriko Uehara, Kenbun Sone, Osamu Hiraike-Wada, Kei Kawana, Tetsu Yano, Yutaka Osuga, Tomoyuki Fujii, and Hiroyuki Aburatani
  • Organizer: AACR 106th Annual Meeting 2015
  • Place of Presentation: Philadelphia, PA
  • Year and Date: 2015-04-18
  • Int'l Joint Research
• [Presentation] 子宮体癌・卵巣明細胞腺癌における分子生物学的特性と治療標的経路の解明 (2015)
  • Author(s): 織田 克利
  • Organizer: 第67回日本産科婦人科学会学術講演会 平成26年度学術奨励賞受賞講演
  • Place of Presentation: 横浜
  • Year and Date: 2015-04-09
  • Invited
• [Presentation] FRETイメージング法を用いた卵巣粘液性腺癌における分子標的薬併用療法の相乗効果の解析 (2015)
  • Author(s): 稲葉 可奈子、織田 克利、青木 一洋、宮坂 亞希、樫山 智子、福田 友彦、牧井 千波、池田 悠至、平池 修、川名 敬、大須賀 穣、藤井 知行
  • Organizer: 第67回日本産科婦人科学会学術講演会
  • Place of Presentation: 横浜
  • Year and Date: 2015-04-09
• [Presentation] 腹水と原発・転移巣における次世代シーケンサーを用いた遺伝子変異解析 腹水のゲノム診断臨床応用に向けて (2015)
  • Author(s): 浅田 佳代、織田 克利、池田 悠至、神尊 貴裕、稲葉 可奈子、福田 友彦、牧井 千波、平池 修、矢野 哲、川名 敬、大須賀 穣、藤井 知行
  • Organizer: 第67回日本産科婦人科学会学術講演会
  • Place of Presentation: 横浜
  • Year and Date: 2015-04-09
• [Presentation] 卵巣明細胞腺癌におけるPI3K/mTOR同時阻害剤DS-7423とMDM2阻害剤Nutlin-3aによる抗腫瘍効果の検討 (2015)
  • Author(s): 牧井 千波、織田 克利、池田 悠至、樫山 智子、宮坂 亞希、福田 友彦、稲葉 可奈子、浅田 佳代、平池 修、川名 敬、大須賀 穣、藤井 知行
  • Organizer: 第67回日本産科婦人科学会学術講演会
  • Place of Presentation: 横浜
  • Year and Date: 2015-04-09
• [Presentation] 卵巣漿液性腺癌におけるHeterogeneityとLiquid Biopsyの意義 (2015)
  • Author(s): 浅田佳代、織田克利、栗川怜子、後藤健吾、神尊貴裕、池田悠至、宮坂亞希、稲葉可奈子、福田友彦、牧井千波、Agapiti Chuwa、竹内真、曾根献文、平池修、矢野哲、川名敬、大須賀穣、藤井知行、油谷浩幸
  • Organizer: 第３回婦人科がんバイオマーカー研究会学術講演会
  • Place of Presentation: 福岡 博多
  • Year and Date: 2015-02-21
• [Presentation] 抗マラリア薬クロロキンはオートファジーを阻害し子宮体癌細胞の増殖を抑制しシスプラチン抵抗性を克服する (2015)
  • Author(s): 福田友彦, 織田克利, 平池修, 曾根献文, 稲葉可奈子, 池田悠至, 樫山智子, 宮坂亜希, 牧井千波, 谷川道洋, 上原ゆり子, 松本陽子, 有本貴英, 矢野哲, 川名敬, 大須賀穣, 藤井知行
  • Organizer: 第15回関東ホルモンと癌研究会
  • Place of Presentation: 東京
  • Year and Date: 2015-01-31
• [Presentation] 卵巣癌治療におけるアバスチン療法～いかに活用していくか？～ (2014)
  • Author(s): 織田 克利
  • Organizer: 第128回関東連合産科婦人科学会
  • Place of Presentation: 長野 松本
  • Year and Date: 2014-10-25 – 2014-10-26
  • Invited
• [Presentation] PI3K/mTOR 同時阻害剤と MEK 阻害剤との併用は子宮体癌において新たな治療戦略となりうる (2014)
  • Author(s): 稲葉 可奈子、織田 克利、宮坂 亞希、池田 悠至、Coumaran Egile、Loic Vincent、Veronique Onado、福田 友彦、平池 修、川名 敬、穣 大須賀 穣、藤井 知行
  • Organizer: 第７３回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] 血中遊離 DNA を用いた次世代シーケンサーによる全エクソン解析法の検討 (2014)
  • Author(s): 浅田 佳代、織田 克利、後藤 健吾、栗川 怜子、山本 尚吾、辰野 健二、上田 宏生、池田 悠至、川名 敬、矢野 哲、大須賀 穣、藤井 知行、油谷 浩幸
  • Organizer: 第７３回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] 卵巣明細胞腺癌・子宮体癌におけるゲノム解析と分子標的治療法の探索 (2014)
  • Author(s): 織田 克利
  • Organizer: 第1回 新潟産婦人科シンポジウム
  • Place of Presentation: 新潟
  • Year and Date: 2014-09-14
  • Invited
• [Presentation] 子宮平滑筋肉腫15例の検討 (2014)
  • Author(s): 鶴賀 哲史, 織田 克利, 大木 慎也, 江口 聡子, 冨尾 賢介, 足立 克之, 長阪 一憲, 松本 陽子, 有本 貴英, 川名 敬, 大須賀 穣, 藤井 知行
  • Organizer: 第52回日本癌治療学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2014-08-28 – 2014-08-30
• [Presentation] 卵巣癌治療におけるベバシズマブへの期待と今後の展望 (2014)
  • Author(s): 織田 克利
  • Organizer: 第56回婦人科腫瘍学会学術講演会
  • Place of Presentation: 栃木 宇都宮
  • Year and Date: 2014-07-17 – 2014-07-19
  • Invited
• [Presentation] 卵巣明細胞腺癌におけるPI3K/mTOR同時阻害剤DS-7423とMDM2阻害剤Nutlin-3aによる抗腫瘍効果の検討 (2014)
  • Author(s): 牧井 千波、織田 克利、池田悠至、樫山智子、宮坂亞希、福田友彦、稲葉可奈子、栗川怜子、神尊貴裕、浅田佳代、竹内真、Agapiti Chuwa、平池修、川名敬、大須賀穣、藤井知行
  • Organizer: 第2回婦人科がんバイオマーカー研究会学術講演会
  • Place of Presentation: 東京
  • Year and Date: 2014-07-05
• [Presentation] 血中遊離DNAを用いた次世代シーケンサーによる遺伝子変異検出法の検討 (2014)
  • Author(s): 浅田佳代、織田克利、栗川怜子、後藤健吾、神尊貴裕、池田悠至、宮坂亞希、稲葉可奈子、福田友彦、牧井千波、Agapiti Chuwa、平池修、矢野哲、川名敬、大須賀穣、藤井知行、油谷浩幸
  • Organizer: 第2回婦人科がんバイオマーカー研究会学術講演会
  • Place of Presentation: 東京
  • Year and Date: 2014-07-05
• [Presentation] 子宮体癌においてPI3K/mTOR同時阻害剤と低用量のMEK阻害剤との併用は新たな治療戦略となりうる (2014)
  • Author(s): 稲葉 可奈子, 織田 克利, 宮坂 亞希, 樫山 智子, 福田 友彦, 牧井 千波, 池田 悠至, 蔵本 博行, 平池 修, 川名 敬, 大須賀 穣, 藤井 知行
  • Organizer: 第66回日本産科婦人科学会学術講演会
  • Place of Presentation: 東京
  • Year and Date: 2014-04-18 – 2014-04-20
• [Presentation] PI3K/mTOR経路阻害剤NVP-BEZ235はp53変異の有無によらず子宮体癌の放射線感受性を増強する (2014)
  • Author(s): 宮坂 亞希, 織田 克利, 池田 悠至, 樫山 智子, 神尊 貴裕, 稲葉 可奈子, 福田 友彦, 牧井 千波, 平池 修, 川名 敬, 大須賀 穣, 藤井 知行
  • Organizer: 第66回日本産科婦人科学会学術講演会
  • Place of Presentation: 東京
  • Year and Date: 2014-04-18 – 2014-04-20
• [Presentation] 卵巣明細胞腺癌における統合的ゲノム・エピゲノム解析 (2014)
  • Author(s): 神尊 貴裕, 織田 克利, 上原 ゆり子, 浅田 佳代, 池田 悠至, 宮坂 亞希, 中川 俊介, 恩田 貴志, 平池 修, 川名 敬, 大須賀 穣, 藤井 知行
  • Organizer: 第66回日本産科婦人科学会学術講演会
  • Place of Presentation: 東京
  • Year and Date: 2014-04-18 – 2014-04-20
• [Presentation] 血中遊離DNAを用いた次世代シーケンサーによる遺伝子変異検出法の検討 (2014)
  • Author(s): 浅田 佳代, 織田 克利, 神尊 貴裕, 池田 悠至, 宮坂 亞希, 稲葉 可奈子, 福田 友彦, 平池 修, 矢野 哲, 川名 敬, 大須賀 穣, 藤井 知行
  • Organizer: 第66回日本産科婦人科学会学術講演会
  • Place of Presentation: 東京
  • Year and Date: 2014-04-18 – 2014-04-20
• [Presentation] プラチナ抵抗性またはプラチナアレルギーを呈した再発卵巣癌におけるネダプラチンの有効性の検討 (2014)
  • Author(s): 金 愛理, 織田 克利, 有本 貴英, 松本 陽子, 長阪 一憲, 足立 克之, 鶴賀 哲史, 冨尾 賢介, 江口 聡子, 川名 敬, 大須賀 穣, 藤井 知行
  • Organizer: 第66回日本産科婦人科学会学術講演会
  • Place of Presentation: 東京
  • Year and Date: 2014-04-18 – 2014-04-20
• [Presentation] Aberrant expression of beta-catenin and cyclin D1 in endometrial cancer. (2014)
  • Author(s): Ikeda Y, Oda K, Koso T et al
  • Organizer: AACR Annual Meeting 2014
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 2014-04-05 – 2014-04-09
• [Presentation] Antitumor effect of a poly (ADP-ribose) polymerase (PARP) inhibitor in endometrial carcinoma cell lines (2014)
  • Author(s): Miyasaka A, Oda K, Ikeda Y et al
  • Organizer: AACR Annual Meeting 2014
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 2014-04-05 – 2014-04-09
• [Book] 第11章 婦人科がん治療の近未来展望 1. 婦人科がん分子標的治療の現状と将来展望 (2017)
  • Author(s): 織田克利
  • Total Pages: 6
  • Publisher: 先端医療研究所 先端医療シリーズ48「臨床医のための最新産科婦人科」
• [Book] 分子標的薬の基礎～婦人科癌で期待できる薬剤を中心に～ (2017)
  • Author(s): 織田克利
  • Total Pages: 7
  • Publisher: 日本産科婦人科学会誌
• [Book] 婦人科がんゲノムデータベース化とその活用 (2016)
  • Author(s): 織田 克利、浅田 佳代
  • Total Pages: 5
  • Publisher: 診断と治療社 産科と婦人科
• [Book] 卵巣明細胞腺癌の予後を予測するバイオマーカー (2016)
  • Author(s): 上原ゆり子、織田克利
  • Publisher: メディカルレビュー社 がん分子標的治療
• [Remarks] 東大病院産婦人科 研究・論文リスト
  • URL: http://plaza.umin.ac.jp/tkyobgyn/recruit/about/report.html
• [Remarks] 東京大学医学部附属病院 婦人科悪性腫瘍グループ
  • URL: http://go.umin.jp/research.html
• [Remarks] 東大病院産婦人科 研修医募集サイト 研究・論文リスト
  • URL: http://plaza.umin.ac.jp/tkyobgyn/recruit/about/report.html
• [Patent(Industrial Property Rights)] 卵巣明細胞腺がん治療薬 (2016)
  • Inventor(s): 織田克利、牧井千波
  • Industrial Property Rights Holder: 織田克利、牧井千波
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2016-143963
  • Filing Date: 2016-07-22
  • Acquisition Date: 2016-08-03
• [Patent(Industrial Property Rights)] MDM2 as a therapeutic potential target and prognostic factor for ovarian clear cell carcinomas (2016)
  • Inventor(s): 織田克利、牧井千波
  • Industrial Property Rights Holder: 織田克利、牧井千波
  • Industrial Property Rights Type: 特許
  • Filing Date: 2016-03-09