| Project/Area Number |
26462521
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
小西 郁生 京都大学, 医学研究科, 名誉教授 (90192062)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 子宮頸癌 / 化学療法 / マイクロアレイ / MRI / 術前化学療法 |
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| Outline of Final Research Achievements |
To investigate the efficacy of neoadjuvant chemotherapy (NAC) followed by radical hysterectomy for cervical cancer, translational research in vitro, in silica, and in vivo was conducted.
Microarray analysis revealed that the glutathione metabolic pathway was significantly associated with NAC-resistance, while serum genotyping revealed that UGT1A1 polymorphisms were associated favor-response. And activation of the TGF-β pathway via the interaction between cacner cells and surrounding cancer-associated fibroblasts facilitated tumor invasion, and increased pSMAD3 expression was a hallmark of metastasis. As the clinical efficacy of individualized therapy for locally advanced cervical cancer, less toxicity of NAC and modified surgery was retrospectively exhibited as a single institute study and a multi-institutional study, retrospectively.
Furthermore, radiomics exhibited magnetic resonance imaging was also a useful predictor of the tumor activity as well as a diagnostic tool.
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