Molucular basis on carcinogenesis in gastric-type adenocarcinoma of the uterine cervix

• Project/Area Number: 26462524
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Kobe University
• Principal Investigator: SUDO TAMOTSU 神戸大学, 医学研究科, 医学研究員 (50397824)
• Co-Investigator(Kenkyū-buntansha): 川上 史 神戸大学, 医学部附属病院, 特定助教 (40565678) ; 森永 友紀子 神戸大学, 医学研究科, 特命助教 (20729404)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 子宮頚部胃型腺癌 / ハイリスクHPV / 子宮頸癌 / 胃型 / HPV / 胃型形質

Outline of Final Research Achievements

(1)The characteristic cytologic findings of gastric-type adenocarcinoma of the uterine cervix(GAS) include monolayered and honeycomb sheets, vacuolar and/or foamy cytoplasm, intracytoplasmic neutrophil entrapment, and vesicular nuclei with prominent nucleoli. (2) High-risk HPVs were detected 10 of 46 cases of GAS (21%).(3)Mutations of PDGFRA( platelet-derived growth factor receptor alpha), APC(Adenomatous polyposis coli) and FLT3(FMS-like tyrosine kinase 3) were identified in 3 cases of GAS via Next Generation Sequencing (NGS).

Research Products

• [Journal Article] A preoperative low cancer antigen 125 level is a useful criterion to determine the optimal timing of interval debulking surgery following neoadjuvant chemotherapy in epithelial ovarian cancer. (2016)
  • Author(s): Morimoto A, Nagao S, Kogiku A, Yamamoto K, Miwa M, Wakahashi S, Ichida K, Sudo T, Yamaguchi S, Fujiwara K.
  • Journal Title: Japanese Journal of Clinical Oncology Volume: 46 Issue: 6 Pages: 517-521
  • DOI: 10.1093/jjco/hyw029
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Diagnosis of desmoplastic small-round-cell tumor by cytogenetic analysis: a case report. (2016)
  • Author(s): Wakahashi S, Sudo T, Ichida K, Sugita S, Hasegawa T, Nagao S, Yamaguchi S, Sakuma T, Yamada H.
  • Journal Title: Clinical Case Reports Volume: 4 Issue: 5 Pages: 520-523
  • DOI: 10.1002/ccr3.558
  • NAID: 120005763198
  • Peer Reviewed / Open Access
• [Journal Article] 1Clinical Features of Neuroendocrine Carcinoma of the Uterine Cervix: A Single-Institution Retrospective Review. (2015)
  • Author(s): Nagao S, Miwa M, Maeda N, Kogiku A, Yamamoto K, Morimoto A, Wakahashi S, Ichida K, Sudo T, Yamaguchi S, Sakuma T, Fujiwara K
  • Journal Title: Int J Gynecol Cancer Volume: 25（7） Issue: 7 Pages: 1300-1305
  • DOI: 10.1097/igc.0000000000000495
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Boron neutron capture therapy (BNCT) as a new approach for clear cell sarcoma (CCS) treatment: Trial using a lung metastasis model of CCS. (2015)
  • Author(s): Andoh T, Fujimoto T, Suzuki M, Sudo T, Sakurai Y, Tanaka H, Fujita I, Fukase N, Moritake H, Sugimoto T, Sakuma T, Sasai H, Kawamoto T, Kirihata M, Fukumori Y, Akisue T, Ono K, Ichikawa H
  • Journal Title: Appl Radiat Isot. Volume: 106 Pages: 195-201
  • DOI: 10.1016/j.apradiso.2015.07.060
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Cytologic features of gastric-type adenocarcinoma of the uterine cervix. (2015)
  • Author(s): Kawakami F, Mikami Y, Sudo T, Fujiwara K, Hirose T, Itoh T.
  • Journal Title: Diagn Cytopathol Volume: 43（10） Issue: 10 Pages: 791-796
  • DOI: 10.1002/dc.23304
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Transcriptional CCND1 expression as a predictor of poor response to neoadjuvant chemotherapy with trastuzumab in HER2-positive/ER-positive breast cancer. (2015)
  • Author(s): Tanioka M, Sakai K, Sudo T, Sakuma T, Kajimoto K, Hirokaga K, Takao S, Negoro S, Minami H, Nakagawa K, Nishio K.
  • Journal Title: Breast Cancer Res Treat Volume: 147(3) Issue: 3 Pages: 513-25
  • DOI: 10.1007/s10549-014-3121-5
  • Peer Reviewed / Open Access
• [Journal Article] Unique Roles of Estrogen-Dependent Pten Control in Epithelial Cell Homeostasis of Mouse Vagina. (2015)
  • Author(s): Miyagawa S, Sato M, Sudo T, Yamada G and Iguchi T.
  • Journal Title: Oncogene. Volume: 34 Issue: 8 Pages: 1035-1043
  • DOI: 10.1038/onc.2014.62
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Alpha-fetoprotein-producing ovarian clear cell adenocarcinoma simulating fetal gut in a postmenopausal woman (2014)
  • Author(s): Akemi Morimoto, Tamotsu Sudo , Toshiko Sakuma , Masanori Yasuda, Kiyoshi Fujiwara
  • Journal Title: Gynecologic Oncology Reports Volume: 8 Pages: 24-26
  • DOI: 10.1016/j.gynor.2014.03.001
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Inhibition of Cell Death and Induction of G2 Arrest Accumulation in Human Ovarian Clear Cells by HNF-1β Transcription Factor: Chemosensitivity Is Regulated by Checkpoint Kinase CHK1. (2014)
  • Author(s): Shigetomi H, Sudo T, Shimada K, Uekuri C, Tsuji Y, Kanayama S, Naruse K, Yamada Y, Konishi N, Kobayashi H.
  • Journal Title: Int J Gynecol Cancer Volume: - Issue: 5 Pages: 838-43
  • DOI: 10.1097/igc.0000000000000136
  • Peer Reviewed
• [Journal Article] Boron neutron capture therapy as new treatment for clear cell sarcoma: Trial on different animal model. (2013)
  • Author(s): Andoh T, Fujimoto T, Sudo T, Suzuki M, Sakurai Y, Sakuma T, Moritake H, Sugimoto T, Takeuchi T, Sonobe H, Epstein AL, Fukumori Y, Ono K, Ichikawa H.
  • Journal Title: Appl Radiat Isot. Volume: 印刷中 Pages: 59-63
  • DOI: 10.1016/j.apradiso.2013.12.007
  • Peer Reviewed
• [Presentation] ﾊｲﾘｽｸHPV L1遺伝子のメチル化状態を指標とした子宮頚部上皮内病変の進展予測 (2014)
  • Author(s): 須藤保・岡智子・山本香澄・三輪真唯子・森本明美・若橋宣・市田耕太郎・山口聡・長尾昌二・藤原潔・吉田智一
  • Organizer: 第31回日本産婦人科感染症研究会学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2014-06-08
• [Presentation] "Transcriptional expression of BCL-2 as predictive of response to neoadjuvant chemotherapy with trastuzumab (2014)
  • Author(s): Maki Tanioka, Kazuko Saka, Tamotsu Sudo, Toshiko Sakuma, Koichi Hirokaga, Shintaro Takao, Shunichi Negoro, Hironobu Minami, Kazuhiko Nakagawa, Kazuto Nishio
  • Organizer: ASCO annual meeting 2014
  • Place of Presentation: Chicago
  • Year and Date: 2014-05-30
• [Presentation] 子宮内膜症性嚢胞におけるCD44ｖ9の発現と活性酸素抵抗性 (2014)
  • Author(s): 重富洋志・植栗千陽・伊東史学・棚瀬康仁・春日祥治・金山清二・川口龍二・吉田昭三・古川直人・大井豪一・小林浩・須藤保
  • Organizer: 第66回日本産科婦人科学会学術講演会
  • Place of Presentation: 東京
  • Year and Date: 2014-04-18