| Project/Area Number |
26462524
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kobe University |
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Principal Investigator |
SUDO TAMOTSU 神戸大学, 医学研究科, 医学研究員 (50397824)
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| Co-Investigator(Kenkyū-buntansha) |
川上 史 神戸大学, 医学部附属病院, 特定助教 (40565678)
森永 友紀子 神戸大学, 医学研究科, 特命助教 (20729404)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 子宮頚部胃型腺癌 / ハイリスクHPV / 子宮頸癌 / 胃型 / HPV / 胃型形質 |
|---|
| Outline of Final Research Achievements |
(1)The characteristic cytologic findings of gastric-type adenocarcinoma of the uterine cervix(GAS) include monolayered and honeycomb sheets, vacuolar and/or foamy cytoplasm, intracytoplasmic neutrophil entrapment, and vesicular nuclei with prominent nucleoli. (2) High-risk HPVs were detected 10 of 46 cases of GAS (21%).(3)Mutations of PDGFRA( platelet-derived growth factor receptor alpha), APC(Adenomatous polyposis coli) and FLT3(FMS-like tyrosine kinase 3) were identified in 3 cases of GAS via Next Generation Sequencing (NGS).
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