| Project/Area Number |
26462526
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | The University of Tokushima |
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Principal Investigator |
IWASA Takeshi 徳島大学, 病院, 特任准教授 (00707903)
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| Co-Investigator(Kenkyū-buntansha) |
苛原 稔 徳島大学, 大学院医歯薬学研究部(医学系), 教授 (20160070)
松崎 利也 徳島大学, 大学院医歯薬学研究部(医学系), 准教授 (70294692)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | ストレス / 卵巣 / 視床下部 / 脂肪組織 / visfatin / 性腺ホルモン / 心理ストレス / 感染ストレス / サイトカイン |
|---|
| Outline of Final Research Achievements |
This study clarified that decrease of serum estradiol level induced by ovariectomy (OVX) increases the central responses to inflammatory stress and that these changes exacerbated febrile response. On the other hand, response to psychological stress was not changed by OVX, indicating that such effects of OVX was specific to inflammatory stress. In addition, this study showed that OVX altered the responses of adipocytokines to inflammatory stress. Because these adipocytokines are related in the stress responses, such changes may be involved in the changes of stress responses induced by OVX.
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