| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Negatively charged adenovirus was processed with positively charged liposomal DOPE/DOTAP/EPC formulated at a concentration of 8 mM at a ratio of 40%, 55%, 5% and further processed with negatively charged chondroitin sulfate having tumor specificity. Processed adenovirus showed tumor-specific anti-tumor effect even in the presence of anti-adenovirus antibody. Since weak negatively charged chondroitin sulfate was not able to sufficiently neutralize strongly positively charged liposomes, treatment with heparin having a strong negative charge shows a stronger antitumor effect even in the presence of the antibody as compared with adenovirus/liposome/chondroitin sulfate complex.
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