Reconstitution of gynecological cancer microenvirnment
| Project/Area Number |
26462542
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
Murata Takuya 川崎医科大学, 医学部, 講師 (20714207)
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| Co-Investigator(Kenkyū-buntansha) |
中村 隆文 川崎医科大学, 医学部, 教授 (20303969)
冨松 拓治 大阪大学, 医学系研究科, 講師 (30346209)
下屋 浩一郎 川崎医科大学, 医学部, 教授 (40291950)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | がんの微小環境 / 癌関連線維芽細胞 / 子宮頸癌 / 細胞間相互作用 / 蛍光細胞標識 / リンパ節転移 / 癌の微小環境 / リンパ節転移遺伝子 / 婦人科がん治療 / ヌードマウス同所移植 / テーラーメイドがん治療 / がん組織バンク / 希少婦人科がん |
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| Outline of Final Research Achievements |
Reconstitution of cancer microenvirnment in vitro and/or in vivo is still difficult to achieve. If complete reconstitution of cancer microenvirnment be possible, it will be the break through to new cancer treatment, making cancer drug screening easier and find new biological mechanism that can be a new treatment target. In the course of the study, we found that cancer-associated fibroblast can make ME180, cervial caner cell line, metastasize to lymph nodes at the rate of as high as 40%, by co-transplanting these two kind of cells in nude mouse subcutaneously, that never occured if single kind of cancer cell was transplanted. By further studying this phenomenon, it may be possible to reconstitute cervical cancer microenvirnment in nude mouse subcutaneous completely.
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Report
(4 results)
Research Products
(9 results)
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[Journal Article] Cervical Cancer Patient-Derived Orthotopic Xenograft (PDOX) Is Sensitive to Cisplatinum and Resistant to Nab-paclitaxel.2017
Author(s)
Murakami T, Murata T, Kawaguchi K, Kiyuna T, Igarashi K, Hwang HK, Hiroshima Y, Hozumi C, Komatsu S, Kikuchi T, Lwin TM, Delong JC, Miyake K, Zhang Y, Tanaka K, Bouvet M, Endo I, Hoffman RM.
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Journal Title
Anticancer Res.
Volume: 37
Pages: 61-65
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Invasion of uterine cervical squamous cell carcinoma cells is facilitated by locoregional interaction with cancer-associated fibroblasts via activating transforming growth factor-beta.2015
Author(s)
Michikazu Nagura, Noriomi Matsumura, Tsukasa Baba, Ryusuke Murakami, Budiman Kharma, Junzo Hamanishi, Ken Yamaguchi, Kaoru Abiko, Masafumi Koshiyama, MasakiMandai, TakuyaMurata, Susan K. Murphy, Ikuo Konishi
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Journal Title
Gynecologic Oncology
Volume: 136
Pages: 104-111
Related Report
Peer Reviewed / Open Access
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[Journal Article] Establishment of a Patient-Derived Orthotopic Xenograft (PDOX) Model of HER- 2-Positive Cervical Cancer Expressing the Clinical Metastatic Pattern.2015
Author(s)
Yukihiko Hiroshima, Yong Zhang, Nan Zhang, Ali Maawy, Sumiyuki Mii, Mako Yamamoto, Fuminari Uehara, Shinji Miwa, Shuya Yano, Takashi Murakami, Masashi Momiyama, Takashi Chishima, Kuniya Tanaka, Yasushi Ichikawa, Michael Bouvet, Takuya Murata, Itaru Endo, Robert M. Hoffman
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Journal Title
Related Report
Peer Reviewed / Open Access
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