Study of the susceptibility to temporary ischemic insults in the vestibulo-cerebellum
| Project/Area Number |
26462547
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Gunma University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | patch-clamp / vestibulo-cerebellum / Purkinje cell / 虚血 / 前庭小脳 / パッチクランプ |
|---|
| Outline of Final Research Achievements |
To clarify the neural pathophysiology underlying central vertigo induced by transient ischemia, such as is observed in vertebrobasilar insufficiency, we focused on the excitatory circuits in the rat cerebellum. In our study, we investigated the effects of oxygen-glucose deprivation (OGD) on sEPSCs in Purkinje cells in vestibulo-cerebellar lobules IX and X. sEPSCs in Purkinje cells in lobules IX and X showed marked enhancement of frequency during the short term treatment of oxygen-glucose deprivation. On the other hand, OGD-induced enhancement of sEPSC was small in other control lobules IV-VI. Furthermore, the complete blockade of OGD-induced enhancement of sEPSCs by TTX indicates that this effect depend on spontaneous firings of presynaptic neurons. These results suggest that Purkinje cells in lobules IX and X are richer in the fundamental excitatory inputs than those in other vermal lobules, which results in high sensitivity to ischemic insults in vestibule-cerebellum.
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Report
(5 results)
Research Products
(21 results)
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[Journal Article] Prospective observational study of carbon-ion radiotherapy for non-squamous cell carcinoma of the head and neck.2017
Author(s)
Shirai K, Saitoh J, Musha A, Abe T, Kobayashi D, Takahashi T, Tamaki T, Kawamura H, Takayasu Y, Shino M, Toyoda M, Takahashi K, Hirato J, Yokoo S, Chikamatsu K, Ohno T, Nakano T
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Journal Title
Cancer Science
Volume: 108
Issue: 10
Pages: 2039-2044
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] CD98 as a novel prognostic indicator for patients with stage III/IV hypopharyngeal squamous cell carcinoma.2014
Author(s)
Toyoda M, Kaira K, Shino M, Sakakura K, Takahashi K, Takayasu Y, Tominaga H, Oriuchi N, Nikkuni O, Suzuki M, Iijima M, Tsukamoto N, Nagamori S, Kanai Y, Oyama T, Chikamatsu K.
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Journal Title
Head Neck.
Volume: in press
Issue: 11
Pages: 1-6
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] Results of carbon ion radiotherapy for mucosal malignant melanoma of the head and neck.2014
Author(s)
Yukihiro Takayasu, Masato Shino, Minoru Toyoda, Katsumasa Takahashi, Kazuaki Chikamatsu, Jun-ichi Saitoh, Katsuyuki Shirai, Tatsuya Ohno, Takashi Nakano
Organizer
AHNS 2014 Annual Meeting
Place of Presentation
Marriott Marquis Hotel in Times Square, New York, USA
Year and Date
2014-06-26 – 2014-06-30
Related Report
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