| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Some infants develop repetitive otitis media as pharyngeal tonsils are exposed to drug resistant bacteria. This maximum factor is thought to be the immunocompetence of the host side. M cells take up foreign antigens such as pathogenic microorganisms in nasopharyngeal related lymphoid tissues and play an important role in mucosal immunity. This M cell was considered to be an important internal factor. However,the hypothesis that "Inadequate quantitative or qualitative status of M cells in the pharyngeal tonsils decreases antigen uptake capacity and decreases the function of early immunity, leading to upper airway refractory infection and repetitive otitis media" could not be proved.
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