The plasticity of the Tonotopic organization of auditory central nervous system in the congenital deaf model.

• Project/Area Number: 26462555
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Jichi Medical University
• Principal Investigator: Ito Makoto 自治医科大学, 医学部, 教授 (50283106)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: central auditory system / developmental / glutamate / microgria / microglia / 周波数特異性 / 聴覚中枢神経核 / 蝸牛破壊モデル / 先天聾

Outline of Final Research Achievements

Unilateral cochlear damage has profound effects on the central auditory pathways in the brain. We examined the effects of unilateral cochlear ablation on VGLUT1 expression in the cochlear nucleus (CN) and the superior olivary complex (SOC) in neonatal rats. VGLUT1 expression in the CN subdivisions (the AVCN, the PVCN and the DCN-deep layers) and the SOC (the MnTB, the LSO and the MSO) ipsilateral to the ablated side was significantly suppressed by unilateral cochlear ablation. Interestingly, VGLUT1 expression in the PVCN and the DCN-deep layers contralateral to the ablated side was also reduced. Our findings indicate that unilateral cochlear ablation affects VGLUT1 expression in the central auditory pathways not only ipsilateral but also contralateral to the ablated side.

Research Products

• [Journal Article] The effects of unilateral cochlear ablation on the expression of vesicular glutamate transporter 1 in the lower auditory pathway of neonatal rats (2017)
  • Author(s): Hasegawa H., Hatano M., Sugimoto H., Ito M., Kawasaki H. and Yoshizaki T.
  • Journal Title: Auris Nasus Larynx Volume: 印刷中 Issue: 6 Pages: 690-699
  • DOI: 10.1016/j.anl.2017.01.007
  • NAID: 120006027764
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] A Case of Congenital Unilateral Facial Nerve Aplasia. (2016)
  • Author(s): Shimada D. M, Nakamura K, Sasaki T, Sugimoto H, Ito M
  • Journal Title: Acta Otolaryngol Case Report Volume: 1 Issue: 1 Pages: 102-105
  • DOI: 10.1080/23772484.2016.1247648
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Soft-wall reconstruction of the canal wall with retrograde bone work for pediatric cholesteatoma: Long-term results. (2016)
  • Author(s): Hatano M, Ito M, Sugimoto H, Noda M, Hasegawa H, Yoshizaki T.
  • Journal Title: Int J Pediatr Otorhinolaryngol. Volume: 2016 Dec;91 Pages: 159-165
  • DOI: 10.1016/j.ijporl.2016.10.029
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Randomized Controlled Trial of Juzen-taiho-to in Children with Recurrent Acute Otitis Media. (2016)
  • Author(s): Ito M, Maruyama Y, Kitamura K, Kobayashi T, Takahashi H, Yamanaka N, Harabuchi Y, Origasa H, Yoshizaki T
  • Journal Title: Auris Nusus Larynx Volume: 該当なし Issue: 4 Pages: 390-397
  • DOI: 10.1016/j.anl.2016.10.002
  • NAID: 130006449195
  • Peer Reviewed
• [Journal Article] Effects of sodium thiosulfate for cisplatin-mediated ototoxicity in patients with head and neck cancer. (2015)
  • Author(s): Ishikawa E, Sugimoto H, Hatano M, Nakanishi Y, Tsuji A, Endo K, Kondo S, Wakisaka N, Murono S, Ito M, Yoshizaki T.
  • Journal Title: Acta Otolaryngol. Volume: 10 Issue: 9 Pages: 1-6
  • DOI: 10.3109/00016489.2015.1035797
  • Peer Reviewed
• [Journal Article] Efficacy of concurrent superselective intra-arterial chemotherapy and radiotherapy for late-stage squamous cell carcinoma of the temporal bone. (2015)
  • Author(s): Hisashi Sugimoto
  • Journal Title: Clinical Otolaryngology Volume: 40 Issue: 5 Pages: 500-504
  • DOI: 10.1111/coa.12431
  • Peer Reviewed
• [Journal Article] Persistent stapedial artery with stapes ankylosis (2014)
  • Author(s): Hisashi Sugimoto
  • Journal Title: Auris Nasus Larynx Volume: 41 Issue: 6 Pages: 582-585
  • DOI: 10.1016/j.anl.2014.05.024
  • Peer Reviewed
• [Journal Article] Factors Affecting Outcomes of Alternating Chemoradiotherapy for Nasopharyngeal Cancer. (2014)
  • Author(s): Ueno T, Endo K, Kondo S, Wakisaka N, Murono S, Ito M, Yoshizaki T.
  • Journal Title: Ann Otol Rhinol Laryngol. Volume: 123(7) Issue: 7 Pages: 509-516
  • DOI: 10.1177/0003489414525122
  • Peer Reviewed
• [Journal Article] Immunoglobulin class switching to IgG4 in Warthin tumor and analysis of serum IgG4 levels and IgG4-positive plasma cells in the tumor. (2014)
  • Author(s): Aga M, Kondo S, Yamada K, Wakisaka N, Yagi-Nakanishi S, Tsuji A, Endo K, Murono S, Ito M, Muramatsu M, Kawano M, Yoshizaki T
  • Journal Title: Hum Pathol Volume: 45(4) Issue: 4 Pages: 793-801
  • DOI: 10.1016/j.humpath.2013.11.012
  • Peer Reviewed
• [Presentation] Retrograde-type Mastoidectomy on Demand with soft-wall reconstruction in Pediatric Cholesteatoma (2015)
  • Author(s): Makoto Ito
  • Organizer: The 30th Politzer Society Meeting
  • Place of Presentation: Niigata, Japan
  • Year and Date: 2015-07-01
  • Int'l Joint Research
• [Presentation] CLINICAL PRACTICE GUIDELINE FOR THE DIAGNOSIS AND MANAGEMENT OF OTITIS MEDIA WITH EFFUSION (OME) IN CHILDREN IN JAPAN -2015 (2015)
  • Author(s): Makoto Ito
  • Organizer: 18th otitis media meeting
  • Place of Presentation: National Harbor/Maryland, USA
  • Year and Date: 2015-06-07
  • Int'l Joint Research
• [Presentation] Cochlear implant in presence of facial nerve anomaly (2014)
  • Author(s): Makoto Ito
  • Organizer: 2nd FIMF Otology-Neurotology Workshop
  • Place of Presentation: Zurich, Switerland
  • Year and Date: 2014-10-03 – 2014-10-04
  • Invited