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Endolymph control system of the endolympatic sac and the stria vascularis

Research Project

Project/Area Number 26462559
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Otorhinolaryngology
Research InstitutionKagawa University

Principal Investigator

Miyashita Takenori  香川大学, 医学部, 准教授 (60363214)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords内耳 / 内リンパ嚢 / イオン輸送 / イメージング / イオンイメージング / 血管条 / 減塩治療 / アルドステロン / メニエール病 / RT-PCR
Outline of Final Research Achievements

A low-salt diet was an effective treatment for patients with Meniere’s disease. This treatment will have a greater effect, when sodium intake is reduced to less than 3 g/day. A low-salt diet may induce an increase in the plasma aldosterone concentration that can activate ion transport and absorbing endolymph in the endolymphatic sac.
We also detected the expression of tricellulin, which is involved in controlling intracellular ion transport, in endolymphatic sac epithelia. Furthermore, we developed a new 3D imaging system for the endolymphatic sac.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (14 results)

All 2017 2016 2015 2014 Other

All Int'l Joint Research (2 results) Journal Article (5 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Acknowledgement Compliant: 2 results,  Open Access: 1 results) Presentation (6 results) (of which Int'l Joint Research: 4 results) Remarks (1 results)

  • [Int'l Joint Research] Keck School of Medicine of USC(米国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Department of Physiology & Biophysics/Zilkha Neurogenetic Institute/Keck School of Medicine of USC(米国)

    • Related Report
      2015 Research-status Report
  • [Journal Article] Ion transport its regulation in the endolymphatic sac: suggestions for clinical aspects of Meniere's disease.2017

    • Author(s)
      Mori N, Miyashita T, Inamoto R, Matsubara A, Mori T, Akiyama K, Hoshikawa H.
    • Journal Title

      Eur Arch Otorhinolaryngol

      Volume: 274 Issue: 4 Pages: 1813-1820

    • DOI

      10.1007/s00405-016-4362-1

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hormonal changes following a low-salt diet in patients with Ménière's disease.2016

    • Author(s)
      Miyashita T, Inamoto R, Fukuda S, Hoshikawa H, Hitomi H, Kiyomoto H, Nishiyama A, Mori N.
    • Journal Title

      Auris Nasus Larynx

      Volume: 未定 Issue: 1 Pages: 52-57

    • DOI

      10.1016/j.anl.2016.03.001

    • NAID

      130006086011

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Prox1 expression in the endolymphatic sac revealed by whole-mount fluorescent imaging of Prox1-GFP transgenic mice.2015

    • Author(s)
      Miyashita T, Burford JL, Hong YK, Gevorgyan H, Lam L, Hoshikawa H, Mori N, Peti-Peterdi J.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 457 Issue: 1 Pages: 19-22

    • DOI

      10.1016/j.bbrc.2014.12.068

    • Related Report
      2015 Research-status Report 2014 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] マウス内リンパ嚢上皮細胞におけるProx1の発現2014

    • Author(s)
      宮下武憲、James Burford、 Young-Kwon Hong、 Janos Peti-Peterdi、森  望
    • Journal Title

      耳鼻咽喉科ニューロサイエンス

      Volume: 28 Pages: 79-79

    • Related Report
      2014 Research-status Report
  • [Journal Article] ラット内リンパ嚢におけるcystic fibrosis transmembrane conductance regulatorの発 現2014

    • Author(s)
      松原あい、宮下武憲、稲本隆平、星川広史、森  望
    • Journal Title

      耳鼻咽喉科ニューロサイエンス

      Volume: 28 Pages: 75-78

    • Related Report
      2014 Research-status Report
  • [Presentation] Hormonal change during salt reduced diet in Meniere’s disease2016

    • Author(s)
      Takenori Miyashita , Ryuhei Inamoto , Shinjiro Fukuda , Hiroshi Hoshikawa , and Nozomu Mori
    • Organizer
      Association for Research in Otolaryngology 39th Annual MidWinter Meering
    • Place of Presentation
      San Diego, California,USA
    • Year and Date
      2016-02-20
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Prox1 Expression in the Endolymphatic Sac revealed by Whole-Mount Fluorescent Imaging of Prox1-GFP Transgenic Mice2015

    • Author(s)
      Takenori Miyashita, James L.Burford, Young-Kwon Hong, Haykanush Gevorgyan, Lisa Lam, Hiroshi Hoshikawa, Nozomu Mori, Janos Peti-Peterdi
    • Organizer
      7th International symposium meniere's disease & inner ear homeostasis disorders
    • Place of Presentation
      Rome、Italy
    • Year and Date
      2015-10-17
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Cystic fibrosis transmembrane conductance regulator in the endolymphatic sac of the rat2015

    • Author(s)
      Ai Matsubara, Miyashita Takenori, Ryuhei Inamoto, Mori Nozomu,
    • Organizer
      7th International symposium meniere's disease & inner ear homeostasis disorders
    • Place of Presentation
      Rome、Italy
    • Year and Date
      2015-10-17
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Cation transport in epithelial cells of the endolymphatic sac2015

    • Author(s)
      Mori Nozomu, Miyashita Takenori, Ai Matsubara
    • Organizer
      7th International symposium meniere's disease & inner ear homeostasis disorders
    • Place of Presentation
      Rome、Italy
    • Year and Date
      2015-10-17
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] メニエール病の減塩治療における各種ホルモン濃度変化と臨床所見2014

    • Author(s)
      宮下武憲、稲本隆平、森 望
    • Organizer
      第73回日本めまい平衡医学会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-05 – 2014-11-08
    • Related Report
      2014 Research-status Report
  • [Presentation] 内リンパ嚢上皮細胞におけるPannexin1の発現2014

    • Author(s)
      宮下武憲、James Burford, 松原あい、Janos Peti-Peterdi, 森 望
    • Organizer
      第32回耳鼻咽喉科ニューロサイエンス研究会
    • Place of Presentation
      大阪
    • Year and Date
      2014-08-30
    • Related Report
      2014 Research-status Report
  • [Remarks] University of Southern California,

    • URL

      http://pibbs.usc.edu/faculty/profile/?fid=82

    • Related Report
      2015 Research-status Report

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Published: 2014-04-04   Modified: 2022-02-21  

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