p38 enhances middle ear proliferation during bacterial otitis media

• Project/Area Number: 26462566
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Juntendo University
• Principal Investigator: FURUKAWA Masayuki 順天堂大学, 医学部, 先任准教授 (20359524)
• Co-Investigator(Kenkyū-buntansha): 岡田 弘子 順天堂大学, 医学部, 助教 (20433774) ; 笠井 美里 順天堂大学, 医学部, 非常勤助教 (70549279)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 急性中耳炎 / 中耳粘膜肥厚 / ｐ３８ / 分子制御 / p38 / 中耳粘膜 / 肥厚 / 中耳炎

Outline of Final Research Achievements

The irreversible hypertrophy of the middle ear mucosa was occurred in chronic otitis media and adhesive otitis media. The molecular mechanism of mucosal hypertrophy by p38 in middle ear was clarified. The new treatmnt of hypertrophy of the middle ear mucosa by p38 antagonist was suggested.