Mechanisms of delayed degeneration of hair cells and spiral ganglion cell
| Project/Area Number |
26462572
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | National Defense Medical College (2015-2016)
独立行政法人国立病院機構(東京医療センター臨床研究センター) (2014) |
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Principal Investigator |
Mizutari Kunio 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 病院 耳鼻咽喉科科, 講師 (40338140)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 有毛細胞 / らせん神経節 / 遅発性細胞脱落 / 内耳エネルギー不全 / 蝸牛内電位 / 内耳 / エネルギー不全 / 3-nitropropionic acid / ミトコンドリア / 内有毛細胞 / 外有毛細胞 / 細胞死 |
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| Outline of Final Research Achievements |
In this research, we analyzed the effect of low endocochlear potential on the survival of hair cells and spiral ganglion cells. First, we successfully made a mouse model of acute mitochondrial dysfunction used by 3-nitropropionic acid (3-NP). This mouse model had severe hearing loss measured by auditory brainstem response (ABR), which was caused by decrease of endocochlear potential. The gradient loss of hair cells and spiral ganglion cells was observed 2 weeks after 3-NP treatment, following severe degeneration of these cells, which causes permanent hearing impairment, was occurred. This degenerative changes were progressive, and progressed from the basal turn toward apex of the cochlea after 3-NP treatment.
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Report
(4 results)
Research Products
(6 results)
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[Journal Article] NRF2 Is a Key Target for Prevention of Noise-Induced Hearing Loss by Reducing Oxidative Damage of Cochlea2016
Author(s)
Honkura, Y. Matsuo, H. Murakami, S. Sakiyama, M. Mizutari, K. Shiotani, A. Yamamoto, M. Morita, I. Shinomiya, N. Kawase, T. Katori, Y. Motohashi, H.
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Journal Title
Sci Rep
Volume: 6
Issue: 1
Pages: 19329-19329
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] High prevalence of CDH23 mutation in patients with congenital high-frequency recessive or sporadic hereditary hearing loss2015
Author(s)
Mizutari K, Mutai H., Namba K., Miyanaga Y., Nakano A., Arimoto Y., Masuda S., Morimoto N., Sakamoto H., Kaga K., Matsunaga T.
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Journal Title
Orphanet Journal of Rare Diseases
Volume: 10
Issue: 1
Pages: 60-60
DOI
Related Report
Peer Reviewed / Open Access
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