| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
In this research, we analyzed the effect of low endocochlear potential on the survival of hair cells and spiral ganglion cells. First, we successfully made a mouse model of acute mitochondrial dysfunction used by 3-nitropropionic acid (3-NP). This mouse model had severe hearing loss measured by auditory brainstem response (ABR), which was caused by decrease of endocochlear potential. The gradient loss of hair cells and spiral ganglion cells was observed 2 weeks after 3-NP treatment, following severe degeneration of these cells, which causes permanent hearing impairment, was occurred. This degenerative changes were progressive, and progressed from the basal turn toward apex of the cochlea after 3-NP treatment.
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