| Project/Area Number |
26462573
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | 独立行政法人国立病院機構(東京医療センター臨床研究センター) |
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Principal Investigator |
Takegoshi Hideki 独立行政法人国立病院機構(東京医療センター臨床研究センター), その他部局等, 研究員 (10302738)
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| Co-Investigator(Kenkyū-buntansha) |
加我 君孝 独立行政法人国立病院機構(東京医療センター臨床研究センター), その他部局等, 名誉臨床研究センター長 又はセンター長 (80082238)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | Auditory Neuropathy / 蝸電図 / ABR / VEMP / GVEMP / クリック / Chirp音 / シナプス電位 / クリップ / ＡＢＲ / ＶＥＭＰ / Ｃhirp音 / ANSD |
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| Outline of Final Research Achievements |
Auditory neuropathy is a newly found hearing disease which was reported by Kaga K, et al and Starr A, et al in 1996 and in the different journals. Auditory neuropathy is characterized by absence of ABR, normal optoacoustic emission and poor N1 but presence of -summating potential of electrocochleography. These featuses of the objective audiometry suggested a synaptic transmission problem between the inner ear hair cell and the cochlear nerve. In order to reveal the pathophysiology of auditory neuropathy, we conducted to record the chirp sound stimulus electrocochleography, ABR and VEMP. Moreover, we introduced newly the galvanic VEMP in order to explore vestibulo neuropathy in patients with congenital and late onset auditory neuropathy and found complication of vestibulo neuropathy in auditory neuropathy.
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