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A study of auditory neuropathy using the chirp sound stimulus ABR and vestibular evoked myogenic potential

Research Project

Project/Area Number 26462573
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Otorhinolaryngology
Research Institution独立行政法人国立病院機構(東京医療センター臨床研究センター)

Principal Investigator

Takegoshi Hideki  独立行政法人国立病院機構(東京医療センター臨床研究センター), その他部局等, 研究員 (10302738)

Co-Investigator(Kenkyū-buntansha) 加我 君孝  独立行政法人国立病院機構(東京医療センター臨床研究センター), その他部局等, 名誉臨床研究センター長 又はセンター長 (80082238)
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsAuditory Neuropathy / 蝸電図 / ABR / VEMP / GVEMP / クリック / Chirp音 / シナプス電位 / クリップ / ABR / VEMP / Chirp音 / ANSD
Outline of Final Research Achievements

Auditory neuropathy is a newly found hearing disease which was reported by Kaga K, et al and Starr A, et al in 1996 and in the different journals. Auditory neuropathy is characterized by absence of ABR, normal optoacoustic emission and poor N1 but presence of -summating potential of electrocochleography. These featuses of the objective audiometry suggested a synaptic transmission problem between the inner ear hair cell and the cochlear nerve. In order to reveal the pathophysiology of auditory neuropathy, we conducted to record the chirp sound stimulus electrocochleography, ABR and VEMP. Moreover, we introduced newly the galvanic VEMP in order to explore vestibulo neuropathy in patients with congenital and late onset auditory neuropathy and found complication of vestibulo neuropathy in auditory neuropathy.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (14 results)

All 2016 2015 2014

All Journal Article (9 results) (of which Peer Reviewed: 4 results) Presentation (3 results) (of which Int'l Joint Research: 1 results) Book (2 results)

  • [Journal Article] Auditory nerve disease and auditory neuropathy specctrum disorders2016

    • Author(s)
      Kaga K
    • Journal Title

      Auris Nasus Larynx

      Volume: 43 Issue: 1 Pages: 10-20

    • DOI

      10.1016/j.anl.2015.06.008

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Usefulness of measuring electrically evoked auditory brainstem responses in children with inner ear malformations during cochlear implantation2015

    • Author(s)
      Minami SB, Takegoshi H, Shinjo Y, Enomoto C, Kaga K
    • Journal Title

      Acta Otolaryngologica

      Volume: 135 Issue: 10 Pages: 1007-1015

    • DOI

      10.3109/00016489.2015.1048377

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] スポーツと平衡機能(三半規管・耳石器の役割)~姿勢反射 vs 随意運動~2015

    • Author(s)
      加我君孝
    • Journal Title

      日本臨床スポーツ医学会誌

      Volume: 23 Pages: 198-200

    • Related Report
      2015 Research-status Report
  • [Journal Article] Auditory neuropathy(成人型)に対する人工内耳手術による聴覚の再獲得2015

    • Author(s)
      加我君孝
    • Journal Title

      ENTONI

      Volume: 181 Pages: 61-67

    • Related Report
      2015 Research-status Report
  • [Journal Article] ANとANSD2015

    • Author(s)
      加我君孝
    • Journal Title

      JOHNS

      Volume: 31 Pages: 1601-1606

    • Related Report
      2015 Research-status Report
  • [Journal Article] 小児の前庭機能の障害と発達―先天性難聴児の前庭半規管障害の運動発達に及ぼす影響について―2015

    • Author(s)
      加我君孝、増田毅
    • Journal Title

      小児耳鼻咽喉科

      Volume: 36 Pages: 251-258

    • NAID

      40021660458

    • Related Report
      2015 Research-status Report
  • [Journal Article] Appearance of ocular vestibular evoked myogenic potentials elicited by bone-conducted vibration in a patient with CHARGE syndrome with aplasia of all semicircular canals.2014

    • Author(s)
      Zhang Q, Kaga K, Takegoshi H, Masuda T
    • Journal Title

      International Journal of Pediatric Otorhinolaryngology

      Volume: 78 Issue: 3 Pages: 555-558

    • DOI

      10.1016/j.ijporl.2013.12.002

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Relationship between acquisition of motor function and vestibular function in children with bilateral sever hearing loss.2014

    • Author(s)
      Masuda T, Kaga K
    • Journal Title

      Acta Otolaryngologica

      Volume: 134 Issue: 7 Pages: 672-678

    • DOI

      10.3109/00016489.2014.890290

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Auditory neuropathy and auditory neuropathy spectrum disorders.2014

    • Author(s)
      Kaga K
    • Journal Title

      Auditory and Vestibular Research

      Volume: 1 Pages: 1-2

    • Related Report
      2014 Research-status Report
  • [Presentation] Auditory Neuropathy2016

    • Author(s)
      加我君孝
    • Organizer
      第78回耳鼻咽喉科臨床学会
    • Place of Presentation
      城山観光ホテル(鹿児島市)
    • Year and Date
      2016-06-23
    • Related Report
      2016 Research-status Report
  • [Presentation] Evaluation by CT and MRI imaging, vestibular function and EABR for cochlear nerve deficiency 20 cases2016

    • Author(s)
      Minami S, Enomoto C, Obuchi C, Shiroma M, Kaga K
    • Organizer
      16th Japan-Korea Joint Meeting of Otorhinolaryngology-Head and Neck Surgery
    • Place of Presentation
      Tokyo(Japan)
    • Year and Date
      2016-03-28
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Common cavity、Cochlear nerve deficiencyのバランス機能発達の比較2015

    • Author(s)
      木村優介、増田毅、南修司郎、加我君孝
    • Organizer
      第74回日本めまい平衡医学会総会
    • Place of Presentation
      長良川国際会議場(岐阜市)
    • Year and Date
      2015-11-25
    • Related Report
      2015 Research-status Report
  • [Book] Cochlear implantation in children with inner ear malformation and cochlear nerve deficiency2016

    • Author(s)
      Kaga K
    • Total Pages
      169
    • Publisher
      Springer
    • Related Report
      2016 Research-status Report
  • [Book] Vertigo and Balance Disorders in Children2014

    • Author(s)
      Kaga K
    • Total Pages
      84
    • Publisher
      Springer
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2019-03-29  

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