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Investigation for the mechanism of macrolide and development for combination therapy with macrolide

Research Project

Project/Area Number 26462578
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Otorhinolaryngology
Research InstitutionMie University

Principal Investigator

Ishinaga Hajime  三重大学, 医学部附属病院, 講師 (50335121)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
KeywordsMUC5AC / マクロライド / MKP-1 / p38 / クラリスロマイシン / p38 / 作用機序
Outline of Final Research Achievements

Low-dose, long-term macrolide therapy is effective in patients with chronic airway diseases such as diffuse panbronchitis, chronic bronchitis, and chronic sinusitis. However, the mechanism underlying this clinical efficacy remains unclear. It was recently reported that MKP-1 appears to mediate the effects of several anti-inflammatory drugs, including glucocorticoids, but the role of MKP-1 on mucin gene expression in the presence of macrolide remains unknown in human airways. Here, we show that MKP-1protein is induced by clarithromycin, and that clarithromycin suppresses TNF-α-induced MUC5AC mucin gene expression in a p38 MAPK-dependent manner in human airway epithelial cells, NCI-H292 cells. Our study thus provides new insights into the role of MKP-1 on the effect of macrolides, and may help in the development of new therapeutic strategies against mucin overproduction.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (6 results)

All 2017 2016 2015 2014

All Journal Article (2 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (4 results)

  • [Journal Article] Interleukin-33 induces mucin gene expression and goblet cell hyperplasia in human nasal epithelial cells.2017

    • Author(s)
      Ishinaga H, et al
    • Journal Title

      Cytokine

      Volume: 90 Pages: 60-65

    • DOI

      10.1016/j.cyto.2016.10.010

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Pathogenesis of eosinophilic chronic rhinosinusitis.2016

    • Author(s)
      Shah SA, Ishinaga H, et al.
    • Journal Title

      J Inflamm

      Volume: 13 Issue: 1 Pages: 1-9

    • DOI

      10.1186/s12950-016-0121-8

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] マクロライド系抗菌薬によるムチン遺伝子発現抑制に対するMKP-1の役割(第二報)2016

    • Author(s)
      石永 一
    • Organizer
      マクロライド審査用研究会
    • Place of Presentation
      飯田橋レインボービル (東京都・新宿区)
    • Year and Date
      2016-07-29
    • Related Report
      2016 Annual Research Report
  • [Presentation] マクロライド系抗菌薬によるムチン遺伝子発現抑制に対するMKP-1の役割(第二報)2016

    • Author(s)
      石永 一
    • Organizer
      マクロライド新作用研究会
    • Place of Presentation
      飯田橋レインボービル(東京都・新宿区)
    • Year and Date
      2016-07-23
    • Related Report
      2015 Research-status Report
  • [Presentation] マクロライド系抗菌薬によるムチン遺伝子発現抑制に対するMKP-1の役割2015

    • Author(s)
      石永 一
    • Organizer
      日本耳鼻咽喉科免疫アレルギー学会
    • Place of Presentation
      東武ホテルアバンテ東京
    • Year and Date
      2015-02-26 – 2015-02-28
    • Related Report
      2014 Research-status Report
  • [Presentation] マクロライド系抗菌薬によるムチン遺伝子発現抑制に対するMKP-1の役割2014

    • Author(s)
      石永 一
    • Organizer
      第1回マクロライド新作用研究会
    • Place of Presentation
      飯田橋レインボービル
    • Year and Date
      2014-07-18 – 2014-07-19
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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