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New strategies for examination and regenerative treatment of olfactory dysfunction

Research Project

Project/Area Number 26462580
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Otorhinolaryngology
Research InstitutionMie University

Principal Investigator

Kobayashi Masayoshi  三重大学, 医学系研究科, 准教授 (80343218)

Co-Investigator(Kenkyū-buntansha) 中川 隆之  京都大学, 医学研究科, 講師 (50335270)
坂本 達則  公益財団法人田附興風会, 医学研究所 第5研究部, 研究員 (60425626)
Co-Investigator(Renkei-kenkyūsha) TABATA Yasuhiko  京都大学, 再生医科学研究所, 教授 (50211371)
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords嗅覚 / 鼻科学 / 光コヒーレンストモグラフィー
Outline of Final Research Achievements

Optical coherence tomography (OCT) is an imaging tool using the coherence of infrared light. The present study aimed to examine the feasibility of OCT for diagnosis of degeneration in the olfactory epithelium using a mouse model.
Changes in the thickness of olfactory epithelia following methimazole treatment, which causes loss of olfactory sensory cells, were estimated by OCT. OCT images demonstrated the difference in thickness between the olfactory and respiratory epithelium similarly to that in hematoxylin and eosin (HE) staining. HE staining revealed a decrease in thickness of olfactory epithelia 3 days after systemic application of methimazole and recovery in thickness overtime, which was also detectable in OCT images.  Present findings demonstrated the capability of OCT for detecting degeneration and regeneration of mouse olfactory epithelia, suggesting future application of OCT for visualization of degeneration and regeneration in olfactory epithelia in humans.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (2 results)

All 2016 2015

All Presentation (2 results)

  • [Presentation] OCTによる鼻粘膜評価の試み2016

    • Author(s)
      上田俊雄
    • Organizer
      第35回耳鼻咽喉科ニューロサイエンス研究会
    • Place of Presentation
      ホテルグランヴィア大阪(大阪府・大阪市)
    • Year and Date
      2016-08-27
    • Related Report
      2016 Research-status Report
  • [Presentation] OCTによる鼻粘膜評価の試み2015

    • Author(s)
      上田俊雄
    • Organizer
      第2回嗅覚冬のセミナー
    • Place of Presentation
      高知市、桂浜荘
    • Year and Date
      2015-01-11
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2019-03-29  

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