| Project/Area Number |
26462583
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
清水 猛史 滋賀医科大学, 医学部, 教授 (00206202)
安岡 公美子 (竹澤 公美子) 滋賀医科大学, 医学部, 助教 (80711837)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | インフルエンザウイルス / マクロライド / クラリスロマイシン / カニクイザル |
|---|
| Outline of Final Research Achievements |
To examine the efficacy of Macrolide antibiotics, including clarithromycin (CAM), a 14-membered ring macrolide against avian influenza virus (H5N1, H7N9) infection, we examined the effects of oral CAM administration in H5N1- or H7N9-infected cynomolgus macaque monkeys.
H5N1 infection caused a severe infection in monkeys, while H7N9 infection resulted in a mild disease. CAM significantly suppressed H5N1-induced severe infection evaluated by the lower clinical score and by the lower body temperature at 5 days after the infection. CAM also significantly inhibited the virus titers in tracheal swab and the production of inflammatory cytokines in lungs in both H5N1- and H7N9- infected monkeys. These findings suggest that orally administered CAM attenuates the severity of avian influenza A virus (H5N1, H7N9) infection in monkeys by inhibiting the infection and reproduction of viruses and by suppressing the cytokines responses of infected lung.
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