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Phenotypes and endotypes of eosinophilic chronic rhinosinusitis

Research Project

Project/Area Number 26462587
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Otorhinolaryngology
Research InstitutionJikei University School of Medicine

Principal Investigator

asaka daiya  東京慈恵会医科大学, 医学部, 講師 (20317928)

Co-Investigator(Kenkyū-buntansha) 和田 弘太  東邦大学, 医学部, 教授 (20307482)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsrhinosinusitis / IL-33 / ILC2 / endotype / 好酸球性副鼻腔炎 / endotype / cluster 解析 / クラスター解析
Outline of Final Research Achievements

Chronic rhinosinusitis is a heterogeneous inflammatory disease whose pathophysiology is not fully understood. Recently, cluster analysis has been used to classify the phenotypes and endotypes of asthma and food allergy. The aim of this study was to investigate CRS endotypes using cluster analysis. A total of 52 patients were enrolled in this study. Diagnosis of eosinophilic chronic rhinosinusitis (ECRS) was based on JESREC STUDY.
The levels of eosinophil in nasal mucosa and sera were significantly elevated in patients with ECRS compared to non ECRS. The levels of IL-13, IL-6 and ILC2 were also significantly elevated in patients with ECRS. Cluster analysis that added measurement of cytokine did not indicate significant difference. So it is important to accumulation of the number of cases of patients in future.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (1 results)

All 2016

All Presentation (1 results) (of which Invited: 1 results)

  • [Presentation] 好酸球性副鼻腔炎の手術治療と術後管理2016

    • Author(s)
      浅香大也
    • Organizer
      第55回鼻科学会総会
    • Place of Presentation
      宇都宮
    • Year and Date
      2016-10-13
    • Related Report
      2016 Annual Research Report
    • Invited

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Published: 2014-04-04   Modified: 2018-03-22  

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