Study of topical antibody production in sinus mucosa of refractory rhinosinusitis cases
| Project/Area Number |
26462589
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Nippon Medical School |
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Principal Investigator |
Matsune Shoji 日本医科大学, 医学部, 教授 (00253899)
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| Co-Investigator(Kenkyū-buntansha) |
大久保 公裕 日本医科大学, 大学院医学研究科, 大学院教授 (10213654)
関根 久遠 日本医科大学, 医学部, 助教 (20566377)
北山 康彦 日本医科大学, 医学部, 教授 (60598704)
石田 麻里子 日本医科大学, 医学部, 助教 (60714780)
山口 智 日本医科大学, 医学部, 助教 (70386209)
臼杵 二郎 日本医科大学, 医学部, 講師 (80318477)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 難治性副鼻腔炎 / 篩骨洞粘膜 / 抗原特異的IgE / 総IgE / 真菌 / 菌体エンテロトキシン / 濾胞樹状細胞 / 好酸球性副鼻腔炎 / 特異的IgE / 総IｇE / カンジダ / スギ / 鼻茸 / 副鼻腔粘膜 / 黄色ブドウ球菌 / エンテロトキシン |
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| Outline of Final Research Achievements |
Intractable chronic rhinosinusitis often complicated with multiple polyposis and asthma is named eosinophilic rhinosinusitis. Our operation cases were classified into two groups such as eosinophilic chronic rhinosinusitis (ECRS) and non-eosinophilic one (nonECRS) and compared topical total and specific IgE levels in ethmoid mucosa between these two groups. In ECRS, the topical total and specific IgE to cedar pollen and candida were significantly increased than in nonECRS. The topical specific IgE to enterotoxin A, B (Staphylococcus aureus) and aspergillus were also increased in ECRS than in nonECRS, which difference was not significant. The distribution of IgE-positive mononuclear cells in ethmoid mucosa was found to support the results of IgE-level analysis, histologically. Follicular dendritic cells were occasionally identified to form inflammatory lymphoid follicles in ethmoid mucosa and supposed to involved in topically producing total and/or specific IgE.
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Report
(4 results)
Research Products
(31 results)
