Elucidation of signaling network of head and neck cancer by bioinformatics approach
| Project/Area Number |
26462591
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
本間 明宏 北海道大学, 医学研究科, 准教授 (30312359)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 頭頸部癌 / バイオインフォマティクス / シグナル伝達 |
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| Outline of Final Research Achievements |
We performed gene analysis in the 500 cases with head and neck cancer to identify mutaion and expression that could be the marker of treatment strategies and treatment targets for head and neck cancer.
An important prognostic factor other than TNM classification is the presence or absence of human papillomavirus (HPV) infection. In general, cancer becomes more malignant as the differentiation progresses, and the prognosis is also worsened in correlation with it. We focused on the progress of epithelial-to-mesenchymal transition as the degree of differentiation declined and the prognosis of cases in which expression of epithelial and mesenchymal markers was examined in each group.The prognosis of patients who have heterogeneity in EMT marker expression were poor. Intra-tumor heterogeneity is low in the surgical samples with HPV positive.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] Effectiveness of superselective intra-arterial chemoradiotherapy targeting retropharyngeal lymph node metastasis.2016
Author(s)
Suzuki T, Sakashita T, Homma A, Hatakeyama H, Kano S, Mizumachi T, Yoshida D, Fujima N, Onimaru R, Tsuchiya K, Yasuda K, Shirato H, Suzuki F, Fukuda S.
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Journal Title
Eur Arch Otorhinolaryngol.
Volume: 273
Issue: 10
Pages: 3331-3336
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Expression of p53, p16, cyclin D1, epidermal growth factor receptor and Notch1 in patients with temporal bone squamous cell carcinoma.2016
Author(s)
Morita S, Nakamaru Y, Homma A, Yasukawa S, Hatakeyama H, Sakashita T, Kano S, Fukuda A, Fukuda S
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Journal Title
Int J Clin Oncol.
Volume: 22
Issue: 1
Pages: 181-189
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] A retrospective study of G-tube use in Japanese patients treated with concurrent chemoradiotherapy for hypopharyngeal cancer.2016
Author(s)
Homma A, Hatakeyama H, Mizumachi T, Kano S, Sakashita T, Kuramoto R, Nakamaru Y, Onimaru R, Tsuchiya K, Yoshida D, Yasuda K, Shirato H, Fukuda S.
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Journal Title
Plos One
Volume: 11
Issue: 8
Pages: e0161734-e0161734
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Decreased SMAD4 expression is associated with induction of epithelial-to-mesenchymal transition and cetuximab resistance in head and neck squamous cell carcinoma.2015
Author(s)
Cheng H, Fertig EJ, Ozawa H, Hatakeyama H, Howard JD, Perez J, Considine M, Thakar M, Ranaweera R, Krigsfeld G, Chung CH.
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Journal Title
Cancer Biology & Therapy
Volume: 16
Pages: 1252-1258
Related Report
Peer Reviewed / Int'l Joint Research
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