Elucidation of signaling network of head and neck cancer by bioinformatics approach

• Project/Area Number: 26462591
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Hokkaido University
• Principal Investigator: Hatakeyama Hiromitsu 北海道大学, 大学病院, 助教 (10455652)
• Co-Investigator(Kenkyū-buntansha): 本間 明宏 北海道大学, 医学研究科, 准教授 (30312359)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 頭頸部癌 / バイオインフォマティクス / シグナル伝達

Outline of Final Research Achievements

We performed gene analysis in the 500 cases with head and neck cancer to identify mutaion and expression that could be the marker of treatment strategies and treatment targets for head and neck cancer.
An important prognostic factor other than TNM classification is the presence or absence of human papillomavirus (HPV) infection. In general, cancer becomes more malignant as the differentiation progresses, and the prognosis is also worsened in correlation with it. We focused on the progress of epithelial-to-mesenchymal transition as the degree of differentiation declined and the prognosis of cases in which expression of epithelial and mesenchymal markers was examined in each group.The prognosis of patients who have heterogeneity in EMT marker expression were poor. Intra-tumor heterogeneity is low in the surgical samples with HPV positive.

Research Products

• [Journal Article] The role of prophylactic neck dissection and tumor thickness evaluation for patients with cN0 tongue squamous cell carcinoma. (2016)
  • Author(s): Tsushima N, Sakashita T, Homma A, Hatakeyama H, Kano S, Mizumachi T, Kakizaki T, Suzuki T, Fukuda S.
  • Journal Title: Eur Arch Otorhinolaryngol. Volume: 273 Pages: 3987-3992
  • DOI: 10.1007/s00405-016-4077-3
  • NAID: 120006360053
  • Peer Reviewed
• [Journal Article] Effectiveness of superselective intra-arterial chemoradiotherapy targeting retropharyngeal lymph node metastasis. (2016)
  • Author(s): Suzuki T, Sakashita T, Homma A, Hatakeyama H, Kano S, Mizumachi T, Yoshida D, Fujima N, Onimaru R, Tsuchiya K, Yasuda K, Shirato H, Suzuki F, Fukuda S.
  • Journal Title: Eur Arch Otorhinolaryngol. Volume: 273 Pages: 3331-3336
  • DOI: 10.1007/s00405-016-3933-5
  • NAID: 120006347189
  • Peer Reviewed
• [Journal Article] Expression of p53, p16, cyclin D1, epidermal growth factor receptor and Notch1 in patients with temporal bone squamous cell carcinoma. (2016)
  • Author(s): Morita S, Nakamaru Y, Homma A, Yasukawa S, Hatakeyama H, Sakashita T, Kano S, Fukuda A, Fukuda S
  • Journal Title: Int J Clin Oncol. Volume: 22 Pages: 181-189
  • DOI: 10.1007/s10147-016-1026-5
  • NAID: 120006382289
  • Peer Reviewed
• [Journal Article] The outcomes of surgery and chemoradiotherapy for temporal bone cancer. (2016)
  • Author(s): Morita S, Homma A, Nakamaru Y, Sakashita T, Hatakeyama H, Kano S, Fukuda A, Fukuda S.
  • Journal Title: Otology & Neurotology Volume: 37 Pages: 1174-1182
  • DOI: 10.1097/mao.0000000000001152
  • Peer Reviewed
• [Journal Article] A retrospective study of G-tube use in Japanese patients treated with concurrent chemoradiotherapy for hypopharyngeal cancer. (2016)
  • Author(s): Homma A, Hatakeyama H, Mizumachi T, Kano S, Sakashita T, Kuramoto R, Nakamaru Y, Onimaru R, Tsuchiya K, Yoshida D, Yasuda K, Shirato H, Fukuda S.
  • Journal Title: PLoS One Volume: 11
  • DOI: 10.1371/journal.pone.0161734
  • NAID: 120005866840
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Decreased SMAD4 expression is associated with induction of epithelial-to-mesenchymal transition and cetuximab resistance in head and neck squamous cell carcinoma. (2015)
  • Author(s): Cheng H, Fertig EJ, Ozawa H, Hatakeyama H, Howard JD, Perez J, Considine M, Thakar M, Ranaweera R, Krigsfeld G, Chung CH.
  • Journal Title: Cancer Biology & Therapy Volume: 16 Pages: 1252-1258
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Hangeshashinto improves the completion rate of chemoradiotherapy and the nutritional status in patients with head and neck cancer. (2015)
  • Author(s): Hatakeyama H, Takahashi H, Oridate N, Kuramoto R, Fujiwara K, Homma A, Takeda H, Fukuda S.
  • Journal Title: ORL Volume: 1 Pages: 100-108
  • NAID: 120005617281
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Hangeshashinto Improves the Completion Rate of Chemoradiotherapy and the Nutritional Status in Patients with Head and Neck Cancer (2015)
  • Author(s): Hatakeyama H, Takahashi, Oridate N, Kuramoto R, Fujiwara K., Homma A, Takeda H.,Fukuda S.
  • Journal Title: ORL Volume: 1 Pages: 100-108
  • DOI: 10.1159/000381026
  • NAID: 120005617281
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Epithelial-mesenchymal transition in human papillomavirus;positive and -negative oropharyngeal squamous cell carcinoma (2014)
  • Author(s): Hiromitsu Hatakeyama, Takatsugu Mizumachi, Tomohiro Sakashita, Satoshi Kano, Akihiro Homma, Satoshi Fukuda
  • Journal Title: Oncol Rep. Volume: 9 Pages: 2673-2679
  • DOI: 10.3892/or.2014.3509
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] High level expression of AMAP1 protein correlates with poor prognosis and survival after surgery of head and neck squamous cell carcinoma patients. (2014)
  • Author(s): Sato H, Hatanaka KC, Hatanaka Y, Hatakeyama H, Hashimoto A, Matsuno Y, Fukuda S, Sabe H.
  • Journal Title: Cell communication and signaling Volume: 12 Pages: 12-17
  • DOI: 10.1186/1478-811x-12-17
  • NAID: 120005438264
  • Peer Reviewed / Open Access
• [Presentation] The Personalized therapy for head and neck cancer using genome and proteome analysis (2016)
  • Author(s): Hiromitsu Hatakkeyama
  • Organizer: The National Romanian Congress of Otorhinolaryngology and Cervico Facial Surgery with International Participation
  • Place of Presentation: Oradea,Romania
  • Year and Date: 2016-10-19
  • Int'l Joint Research / Invited
• [Presentation] 頭頸部癌における免疫チェックポイント分子と増殖・刺激因子シグナル伝達経路 (2016)
  • Author(s): 畠山 博充
  • Organizer: 第40回日本頭頸部癌学会
  • Place of Presentation: ソニックシティ（埼玉県さいたま市）
  • Year and Date: 2016-06-09
• [Presentation] 頭頸部癌ゲノム・プロテオーム解析からの個別化分子標的治療へ (2015)
  • Author(s): 畠山 博充 本間明宏 坂下智博 水町貴諭 加納里志 蠣崎文彦 福田 諭
  • Organizer: 第53回日本癌治療学会学術集会
  • Place of Presentation: 京都国際会館（京都府京都市）
  • Year and Date: 2015-10-29
  • Invited
• [Presentation] Clinical adaptation of CRM197 for the treatment of head and neck cancer (2015)
  • Author(s): Hiromitsu Hatakeyama Tomohiro Sakashita Satoshi Kano Takatsugu Mizumachi Akihiro Homma Satoshi Fukuda
  • Organizer: 第53回日本癌治療学会学術集会
  • Place of Presentation: 京都国際会館（京都府京都市）
  • Year and Date: 2015-10-29
  • Int'l Joint Research
• [Presentation] The role of microRNAs in the malignant transformation of sinonasal inverted papilloma (2015)
  • Author(s): Hiromitsu Hatakeyama, Yuji Nakamaru , Dai Takagi, Akihiro Homma,Takatsugu Mizumati Satoshi Kano, Tomohiro Sakashita and Satoshi Fukuda
  • Organizer: 3rd Congress of European ORL-HNS
  • Place of Presentation: GUARANT International(Checz,Prague)
  • Year and Date: 2015-06-07
  • Int'l Joint Research
• [Presentation] 中咽頭癌超選択的動注化学療法と放射線の同時併用療法後舌骨壊死への対応 (2015)
  • Author(s): 畠山博充、本間明宏、坂下智博、加納里志、水町貴諭、福田諭
  • Organizer: 第25回日本頭頸部外科学会総会ならびに学術講演会
  • Place of Presentation: コングレコンベンションセンター（大阪市）
  • Year and Date: 2015-01-29 – 2015-01-30
• [Presentation] セツキシマブ投与における EGFRリガンド発現変化と効果 (2014)
  • Author(s): 畠山博充、本間明宏、坂下智博、加納里志、水町貴諭、福田諭
  • Organizer: 第38回日本頭頸部癌学会
  • Place of Presentation: 東京ファッションタウンビル（東京都）
  • Year and Date: 2014-06-12 – 2014-06-13
• [Presentation] Antley-Bixler症候群における気道確保 (2014)
  • Author(s): 畠山博充、本間明宏、坂下智博、加納里志、水町貴諭、福田諭
  • Organizer: 第18回世界気管食道会議
  • Place of Presentation: 京都国際会館（京都市）
  • Year and Date: 2014-04-13 – 2014-04-16