Clinical and bacteriological analyses of deepneck infections

• Project/Area Number: 26462594
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Tohoku University
• Principal Investigator: Hiroshi Hidaka 東北大学, 医学系研究科, 准教授 (40302103)
• Co-Investigator(Kenkyū-buntansha): 矢野 寿一 奈良県立医科大学, 医学部, 教授 (20374944)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 重症感染症 / 深頸部膿瘍 / 細菌培養 / 分子生物学 / 成人 / 小児 / 培養検査 / 次世代シークエンサー / 糖尿病 / 合併症

Outline of Final Research Achievements

Deep neck infections (DNIs) can lead to life-threatening disease. However, the detailed pathophysiology remains unclear due to its rarity and only a few reports have directly compared DNIs in children and adults. The present study aimed to reveal the clinical differences between DNIs in children and adults. DNIs in children feature different characteristics from those in adults regarding severity, antecedent illness, bacteriology, and clinical management.
Diabetes was associated with higher prevalences of multispace spread of infection, complications, and failure to identify pathogenesis, with risk ratios (RRs) of 1.96, 2.42, and 1.29, respectively. Specifically, in some cases encountering difficulty in clinical management, molecular technique succeeded in identifying unique bacteria.

Research Products

• [Journal Article] Osteoid osteoma of the temporal bone manifesting only as first bite syndrome and systematic review combined with osteoblastoma (2017)
  • Author(s): Hidaka H, Yamauchi D, Fujishima F, Watanabe M, Kato Y, Nomora K, Watanabe K, Kawase T Katori Y
  • Journal Title: Eur Arch Otorhinolaryngol. Volume: 274(2) Issue: 2 Pages: 607-616
  • DOI: 10.1007/s00405-016-4050-1
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Predicting postoperative fever and bacterial colonization on packing material following endoscopic endonasal surgery. (2017)
  • Author(s): Nomura K, Yamanaka Y, Sekine Y, Yamamoto H, Esu Y, Hara M, Hasegawa M, Shinnabe A, Kanazawa H, Kakuta R, Ozawa D, Hidaka H, Katori Y, Yoshida N.
  • Journal Title: Eur Arch Otorhinolaryngol. Volume: 274 Issue: 1 Pages: 167-73
  • DOI: 10.1007/s00405-016-4189-9
  • Peer Reviewed
• [Journal Article] First report of severe acute otitis media caused by Campylobacter rectus and review of the literature. (2016)
  • Author(s): Kakuta R, Hidaka H, Yano H, Okamoto M, Ozawa D, Endo S, Kaku M, Katori Y.
  • Journal Title: J Infect Chemother. Volume: 22 Issue: 12 Pages: 800-3
  • DOI: 10.1016/j.jiac.2016.06.001
  • Peer Reviewed
• [Journal Article] Clinical and bacteriological influence of diabetes mellitus on deep neck infection: Systematic review and meta-analysis. (2015)
  • Author(s): Hidaka H, Yamaguchi T, Hasegawa J, Yano H, Kakuta R, Ozawa D, Nomura K, Katori Y.
  • Journal Title: Head Neck Volume: 37(10) Issue: 10 Pages: 1536-46
  • DOI: 10.1002/hed.23776
  • Peer Reviewed / Open Access
• [Journal Article] Impact of the 7-valent pneumococcal conjugate vaccine on acute otitis media in Japanese children: Emergence of serotype 15A multi-drug resistant Streptococcus pneumoniae in middle ear fluid isolates. (2015)
  • Author(s): Ozawa D, Yano H, Endo S, Hidaka H, Kakuta R, Okitsu N, Kanamori H, Ogawa M, Ichimura S, Shimojima M, Inomata S, Kaku M, and Katori Y.
  • Journal Title: Pediatr Infect Dis J. Volume: 34 Issue: 9 Pages: 217-21
  • DOI: 10.1097/inf.0000000000000776
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Minimum invasive trans-nasal approach to infratemporal fossa abscess (2015)
  • Author(s): Nomura K, Hidaka H, Takata Y, Katori Y
  • Journal Title: J Laryngol Otol Volume: 129(8) Issue: 8 Pages: 812-6
  • DOI: 10.1017/s0022215115001541
  • Peer Reviewed / Open Access
• [Journal Article] Intraoral drainage under surgical microscopy with tonsillectomy for parapharyngeal abscess. (2015)
  • Author(s): Okumura Y, Hidaka H, Noguchi N, Katori Y
  • Journal Title: J Laryngol Otol Volume: 129(6) Issue: 6 Pages: 595-7
  • DOI: 10.1017/s0022215115000791
  • Peer Reviewed / Open Access
• [Journal Article] Change in and long-term investigation of neuro-otologic disorders in disaster-stricken Fukushima prefecture: retrospective cohort study before and after the Great East Japan Earthquake (2015)
  • Author(s): Hasegawa J, Hidaka H, Kuriyama S, Obara T, Hashimoto K, Tateda Y, Okumura Y, Kobayashi T, Katori Y
  • Journal Title: PLOS One Volume: 10(4) Issue: 4 Pages: e0122631-e0122631
  • DOI: 10.1371/journal.pone.0122631
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Intraoral drainage under surgical microscopy with tonsillectomy for parapharyngeal abscess. (2015)
  • Author(s): Okumura Y, Hidaka H, Noguchi N, Katori Y.
  • Journal Title: J Laryngol Otol Volume: in press
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Dislocated dental bridge covering the larynx: usefulness of tracheal tube guides under video-assisted laryngoscopy for induction of general anesthesia, thus avoiding tracheostomy. (2014)
  • Author(s): Hidaka H, Suzuki T, Toyama H, Kurosawa S, Nomura K, Katori Y.
  • Journal Title: Head Face Med. Volume: 10 Issue: 1 Pages: 1-4
  • DOI: 10.1186/1746-160x-10-23
  • Peer Reviewed
• [Journal Article] Twelve-year survey (2001-2012) of the antimicrobial susceptibility of Streptococcus pneumoniae isolates from otorhinolaryngology clinics in Miyagi Prefecture, Japan (2014)
  • Author(s): Ozawa D, Yano H, Hidaka H, Kakuta R, Komatsu M, Endo S, Kanamori H, Kaku M, and Katori Y
  • Journal Title: J Infect Chemother Volume: 20 Issue: 11 Pages: 702-708
  • DOI: 10.1016/j.jiac.2014.07.014
  • Peer Reviewed
• [Journal Article] Severe acute otitis media caused by mucoid streptococcus pyogenes in a previously healthy adult. (2014)
  • Author(s): Kakuta R, Yano H, Hidaka H, Miyazaki H, Irimada M, Oda K, Arai K, Ozawa D, Takahashi T, Kaku M, Katori Y.
  • Journal Title: Tohoku J Exp Med Volume: 232 Pages: 301-304
  • NAID: 130004460123
  • Peer Reviewed
• [Presentation] 深頸部膿瘍における小児例と成人例の違いに関する検討 (2017)
  • Author(s): 日高 浩史, 渡邊 健一, 香取 幸夫
  • Organizer: 第27回日本頭頸部外科学会
  • Place of Presentation: 京王プラザホテル（東京都・新宿区）
  • Year and Date: 2017-02-02
• [Presentation] シンポジウム2「誤嚥のリスクと対応」深頸部膿瘍・壊死性降下性縦隔炎に対する排膿術後の嚥下障害併発に関する検討 (2016)
  • Author(s): 日高 浩史
  • Organizer: 第68回 日本気管食道科学会
  • Place of Presentation: 京王プラザホテル（東京都・新宿区）
  • Year and Date: 2016-11-17
  • Invited
• [Presentation] 小児深頸部膿瘍における成人例の違いに関する検討 (2016)
  • Author(s): 日高 浩史, 小澤 大樹, 平野 愛, 野村 有理, 野口 直哉, 角田 梨紗子, 矢野 寿一, 香取 幸夫
  • Organizer: 第11回日本小児耳鼻咽喉科学
  • Place of Presentation: ホテルクレメント徳島（徳島市・寺島本町）
  • Year and Date: 2016-06-30
• [Presentation] 壊死性降下性縦隔炎に対する排膿術後の嚥下障害併発に関する検討 (2016)
  • Author(s): 日高 浩史, 小澤 大樹, 平野 愛, 角田 梨紗子, 菅野 景子, 嵯峨井 俊, 渡邊 健一, 香取 幸夫
  • Organizer: 第117回日本耳鼻咽喉科学会
  • Place of Presentation: 名古屋国際会議場（愛知県・名古屋市）
  • Year and Date: 2016-05-19
• [Presentation] Objective tinnitus by closing of the bite attributed to the connection between the temporomandibular joint and middle ear (2015)
  • Author(s): Hidaka H, Tetawaki Y, Sakamoto M,Kobayashi T, Yuasa Y, Yuasa R, NomuraK, Yamauchi D, Katori Y
  • Organizer: 13th Japan-Taiwan Joint Meeting of Otolaryngology-Head and Neck Surgery
  • Place of Presentation: Tokyo (Hitotsubashi Hall)
  • Year and Date: 2015-12-03
  • Int'l Joint Research
• [Presentation] 側頭骨の類骨骨種(osteoid osteoma)、並びに骨芽細胞腫(osteoblastoma）に関するシステマテックレビュー (2015)
  • Author(s): 日高浩史、山内大輔、野村和弘、渡邊健一、川瀬哲明、香取幸夫
  • Organizer: 第25回日本耳科学会総会
  • Place of Presentation: 長崎（長崎ブリックホール）
  • Year and Date: 2015-10-07
• [Presentation] 臨床ミニセミナー5 「口蓋扁桃摘出術：術後出血の予防と対応：手術用顕微鏡を用いた口蓋扁桃摘出術とその応用」 (2015)
  • Author(s): 日高浩史
  • Organizer: 第28回 日本口腔・咽頭学会総会
  • Place of Presentation: 大阪（ホテル阪神）
  • Year and Date: 2015-09-10
  • Invited
• [Presentation] 急性中耳炎、ならびに副鼻腔炎が関与していると考えられた硬膜外膿瘍の1例 (2015)
  • Author(s): 日高浩史, 角田梨紗子, 小澤大樹, 入間田美保子, 矢野寿一, 香取幸夫
  • Organizer: 第3回耳鼻咽喉科感染症・エアロゾル学会総会
  • Place of Presentation: 札幌（ホテルライフォート札幌）
  • Year and Date: 2015-09-03
• [Presentation] Campylobacer rectusが原因と考えられた急性中耳炎の一例 (2015)
  • Author(s): 角田梨紗子, 日高浩史, 小澤大樹, 入間田美保子, 矢野寿一, 香取幸夫
  • Organizer: 第3回耳鼻咽喉科感染症・エアロゾル学会総会
  • Place of Presentation: 札幌（ホテルライフォート札幌）
  • Year and Date: 2015-09-03
• [Presentation] Osteoid osteoma of the temporal bone manifesting only as first-bite syndrome and systematic review (2015)
  • Author(s): Hidaka H, Kaitani T, Yamauchi D, Kato Y, Fujishima F, Watanabe M, Numora K, Kawase T, Katori Y
  • Organizer: 30th Politzer Society Meeting
  • Place of Presentation: Nigata, Japan (Toki Messe)
  • Year and Date: 2015-06-30
  • Int'l Joint Research
• [Presentation] Molecular epidermology of Ampicillin-resistant Haemophilus influenza causing acute otitis media in Japan infants and young children. (2015)
  • Author(s): Kakuta R, Yano H, Hidaka H, Ozawa D, Kanamori H, Endo S, Ichimura S,
  • Organizer: 13th Asian-Oceania ORL-HNS Congress
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2015-03-19 – 2015-03-22
• [Presentation] Systematic reviewとmeta-analysisからみた糖尿病が深頸部膿瘍に与える影響 (2014)
  • Author(s): 日高浩史、長谷川 純、小澤大樹、角田梨紗子、河本 愛、香取幸夫
  • Organizer: 第66回日本気管食道科学会総会ならびに学術講演会
  • Place of Presentation: 高知(高知県立県民文化ホール）
  • Year and Date: 2014-11-13 – 2014-11-14
• [Presentation] Systematic reviewとmeta-analysisからみた糖尿病が深頸部膿瘍に与える影響～細菌学的観点から～ (2014)
  • Author(s): 日高浩史、小澤大樹、角田梨紗子、香取幸夫、矢野寿一
  • Organizer: 第2回日本耳鼻咽喉科感染症・エアロゾル学会総会・学術講演会
  • Place of Presentation: 東京(東京ステーションコンファレンス）
  • Year and Date: 2014-09-05 – 2014-09-06
• [Book] EBM 耳鼻咽喉・頭頸部外科の治療（2015-2016）, 武田憲昭ら編, 中外医学社, 東京.(2015:36-40) (2015)
  • Author(s): 日高浩史, 小林俊光
  • Total Pages: 688
  • Publisher: 中外医学社