Elucidation of mechansim to form pre-metastatic niche in nasopharyngeal carcinoma and development of exosome for its treatment
Project/Area Number |
26462597
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Otorhinolaryngology
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Research Institution | Kanazawa University |
Principal Investigator |
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Co-Investigator(Renkei-kenkyūsha) |
YOSHIZAKI Tomokazu 金沢大学, 医学系, 教授 (70262582)
MURONO Shigeyuki 福島県立医科大学, 医学部, 教授 (20345622)
KONDO Satoru 金沢大学, 附属病院, 助教 (70436822)
ENDO Kazuhira 金沢大学, 附属病院, 助教 (30547154)
TSUJI Akira 金沢大学, 医学系, 協力研究員 (70632652)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 上咽頭癌 / EBV / EBERs / miR-BARTs / エクソソーム / Argonaute 2 / LMP1 / 前転移ニッチ |
Outline of Final Research Achievements |
EBV-associated oncoprotein, LMP1, was not detected in nasopaheryngeal carcinoma (NPC) cell line, C666.1,-derived exosomes. In contrast, EBV-associated RNAs, such as EBERs and BART-miRNAs, was easily detected in the exosomes. One of BART-miRNAs, miR-BART17-5p, was secreted in extra-ordinally pathway, but in exsosome-independent pathway. The miRNA would be expected as novel therapeutic target of NPC.
|
Report
(4 results)
Research Products
(21 results)
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[Journal Article] Potential Interest in Circulating miR-BART17-5p As a Post-Treatment Biomarker for Prediction of Recurrence in Epstein-Barr Virus-Related Nasopharyngeal Carcinoma2016
Author(s)
Hirai N, Wakisaka N, Kondo S, Aga M, Moriyama-Kita M, Ueno T, Nakanishi Y, Endo K, Sugimoto H, Murono S, Sato H, Yoshizaki T.
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Journal Title
PLOS ONE
Volume: 11
Issue: 9
Pages: e0163609-e0163609
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] T-status and an oral fluoropyrimidine, S-1, adjuvant chemotherapy are prognostic factors in reduced-RADPLAT for resectable hypopharyngeal cancer2016
Author(s)
Wakisaka N, Hirai N, Kondo S, Aga M, Nakanishi Y, Tsuji A, Endo K, Murono S, Yoshizaki T
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Journal Title
Acta Otolaryngol
Volume: 136
Issue: 8
Pages: 834-840
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] HPV Status Determines the Efficacy of Adjuvant Chemotherapy With S-1, an Oral Fluorouracil Prodrug, in Oropharyngeal Cancer2015
Author(s)
Wakisaka N, Yoshida S, Kondo S, Kita M, Endo K, Tsuji A, Murono S, Muramatsu M, Yoshizaki T
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Journal Title
Ann Otol Rhinol Laryngol
Volume: 124
Issue: 5
Pages: 400-6
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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