• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Therapeutic approach to recurrent respiratory papillomatosis from the perspective of signal transduction of human papillomavirus

Research Project

Project/Area Number 26462598
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Otorhinolaryngology
Research InstitutionFukushima Medical University (2016)
Kanazawa University (2014-2015)

Principal Investigator

Murono Shigeyuki  福島県立医科大学, 医学部, 教授 (20345622)

Co-Investigator(Renkei-kenkyūsha) YOSHIZAKI Tomokazu  金沢大学, 医学系, 教授 (70262582)
WAKISAKA Naohiro  金沢大学, 医学系, 准教授 (70377414)
KONDO Satoru  金沢大学, 大学病院, 講師 (70436822)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords喉頭乳頭腫 / HPV / VEGF / 血管新生 / うがい液
Outline of Final Research Achievements

Recurrent respiratory papillomatosis (RRP) is a refractory human papillomavirus (HPV)-associated disease. We tried to establish a tissue culture model of RRP. We confirmed growth of tumor cells in the primary tissue culture. However, continuing growth of those cells could not be achieved in following passage. On the other hand, immunohistochmestry was also performed to investigate a factor for a novel therapy. Expression of vascular endothelial growth factor (VEGF) was observed around fibrovascular cores of RRP. VEGF was observed in cores without an obvious vascular structure. Therefore, anti-VEGF antibody therapy can be a candidate for a novel therapy of RRP.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (8 results)

All 2017 2016 2015 2014

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (5 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Usefulness of human papillomavirus detection in oral rinse as a biomarker of oropharyngeal cancer2017

    • Author(s)
      Yoshida H, Murono S, Ueno T, Nakanishi Y, Tsuji A, Hatano M, Endo K, Kondo S, Sugimoto H, Wakisaka N, Yoshizaki T
    • Journal Title

      Acta Otolaryngol

      Volume: - Issue: 7 Pages: 773-777

    • DOI

      10.1080/00016489.2016.1274426

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intralesional cidofovir injection for recurrent respiratory papillomatosis in Japan2016

    • Author(s)
      Murono S, Nakanishi Y, Tsuji A, Endo K, Kondo S, Wakisaka N, Yoshizaki T
    • Journal Title

      Auris Nasus Larynx

      Volume: 印刷中 Issue: 5 Pages: 541-545

    • DOI

      10.1016/j.anl.2016.01.005

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Trends in the management of recurrent respiratory papillomatosis in Japan2015

    • Author(s)
      Murono S, Nakanishi Y, Tsuji A, Endo K, Kondo S, Wakisaka N, Yoshida H, Yoshizaki T
    • Journal Title

      Auris Nasus Larynx

      Volume: in press Issue: 3 Pages: 218-220

    • DOI

      10.1016/j.anl.2014.10.006

    • NAID

      120005516446

    • Related Report
      2015 Research-status Report 2014 Research-status Report
    • Peer Reviewed
  • [Presentation] うがい液HPV検出の中咽頭癌バイオマーカーとしての可能性2016

    • Author(s)
      室野重之,上野貴雄,中西庸介,辻 亮,遠藤一平,近藤 悟,脇坂尚宏,吉崎智一
    • Organizer
      第40回日本頭頸部癌学会
    • Place of Presentation
      ソニックシティ,さいたま市
    • Year and Date
      2016-06-09
    • Related Report
      2016 Annual Research Report
  • [Presentation] 喉頭乳頭腫におけるVEGF-Aの発現2016

    • Author(s)
      室野重之,中西庸介,辻 亮,遠藤一平,近藤 悟,脇坂尚宏,吉崎智一
    • Organizer
      第117回日本耳鼻咽喉科学会総会・学術講演会
    • Place of Presentation
      名古屋国際会議場,名古屋市
    • Year and Date
      2016-05-19
    • Related Report
      2016 Annual Research Report
  • [Presentation] Angiogenic factors in recurrent respiratory papillomatosis2016

    • Author(s)
      Murono S, Nakanishi Y, Yoshizaki T
    • Organizer
      19th World Congress for Bronchoesophagology
    • Place of Presentation
      Fortezza da Basso, Florence, Italy
    • Year and Date
      2016-05-08
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Angiogenic factors in recurrent respiratory papillomatosis2015

    • Author(s)
      Shigeyuki Murono, Yosuke Nakanishi, Tomokazu Yoshizaki
    • Organizer
      30th International Papillomavirus Conference
    • Place of Presentation
      Centro de Congressos de Lisboa, Lisbon, Portugal
    • Year and Date
      2015-09-17
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] NBI内視鏡による喉頭乳頭腫の観察2014

    • Author(s)
      室野重之,吉崎智一
    • Organizer
      第66回日本気管食道科学会
    • Place of Presentation
      高知市 三翠園
    • Year and Date
      2014-11-13 – 2014-11-14
    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi