| Project/Area Number |
26462600
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Otorhinolaryngology
|
|---|
| Research Institution | Hamamatsu University School of Medicine |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
峯田 周幸 浜松医科大学, 医学部, 教授 (40190714)
三澤 清 浜松医科大学, 医学部附属病院, 講師 (90334979)
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
|---|
| Keywords | 頭頸部癌 / DNAメチル化酵素 / 脱メチル化酵素 / Tet-assist Bisulfite 法 / 脱メチル化解析 / 脱メチル化 / 5-ヒドロキメチルシトシン |
|---|
| Outline of Final Research Achievements |
This study examined DNA methylation enzymes (DNMT3A, DNMT3B) and DNA demethylation enzymes (TET1, TET2, TET3) expression and profiles of head and neck cancer (HNSCC) patients. This study suggests that DNMT3A, DNMT3B, TET1, TET2, TET3 are a likely mechanism of X gene inactivation, supporting the hypothesis that the X gene may play a role in the tumorigenesis of HNSCC and may serve as an important biomarker.
|
