Mechanism of subepithelial invasion in the superficial pharyngeal cancer

Research Project

Project/Area Number	26462602
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Otorhinolaryngology
Research Institution	Kyoto University
Principal Investigator	Tateya Ichiro 京都大学, 医学研究科, 講師 (20526363)
Co-Investigator(Kenkyū-buntansha)	平野滋京都府立医科大学, 医学(系)研究科(研究院), 教授 (10303827) 武藤学京都大学, 医学研究科, 教授 (40360698) 北村守正京都大学, 医学研究科, 助教 (60543262) 岸本曜京都大学, 医学研究科, 特定病院助教 (80700517) 森田真美京都大学, 医学研究科, 医員 (90637597) 石川征司京都大学, 医学(系)研究科(研究院), その他 (70570159)
Project Period (FY)	2014-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000) Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords	咽頭癌 / 表在癌 / 上皮下浸潤 / アラキドン酸 / イメージングマススペクトロメトリー / 下咽頭 / リン脂質 / 質量顕微鏡 / 頭頸部癌
Outline of Final Research Achievements	Superficial-type pharyngeal squamous cell carcinoma (STPSCC) is defined as carcinoma in situ or microinvasive squamous cel lcarcinoma without invasion to the muscular layer. Imaging mass spectrometry (IMS) is suitable for phospholipid analysis because this technique can distinguish even fatty acid compositions and was conducted to elucidate the distribution of PC species in STPSCC tissues. STPSCC tissue sections from five patients were analyzed, and we found that three kinds of phosphatidylcholine species containing arachidonic acid were increased in the subepithelial invasive region. These results may be associated with the invasion mechanism of hypopharyngeal carcinoma.