| Project/Area Number |
26462607
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Kochi University |
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Principal Investigator |
MATSUMOTO Shuichi 高知大学, 教育研究部医療学系臨床医学部門, 助教 (50633997)
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| Co-Investigator(Kenkyū-buntansha) |
兵頭 政光 高知大学, 教育研究部医療学系臨床医学部門, 教授 (00181123)
奥谷 文乃 高知大学, 教育研究部医療学系看護学部門, 教授 (10194490)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | カプサイシン / 嚥下障害 / 嚥下内視鏡検査 / TRPV1 / 嚥下圧検査 / 嚥下造影検査 / fMRI |
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| Outline of Final Research Achievements |
Swallowing videoendoscopy(VE) and swallowing videofluorography were performed on 14 patients with various swallowing disorders, and oral administration of capsaicin film was performed. After 4 weeks, VE was performed to evaluate the effect of swallowing improvement. Treatment was completed in 7 cases, and improvement of VE score was confirmed. In terms of items, swallowing reflex was evoked significantly improved. There were 7 cases of discontinuation of administration, 4 cases of dropout, discomfort, 2 cases of pause due to enhancement of cough reflex, 1 other case.
For healthy subjects, administration of capsaicin film for 4 weeks resulted in an increase in blood substance level P concentration.
TRV1 stimulation using capsaicin film is considered as a simple treatment method which can expect functional effect improvement effect on various dysphagia patients.
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