| Project/Area Number |
26462610
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
Suzuki Mikio 琉球大学, 医学(系)研究科(研究院), 教授 (00226557)
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| Co-Investigator(Kenkyū-buntansha) |
上原 貴行 琉球大学, 医学部附属病院, 助教 (00644402)
真栄田 裕行 琉球大学, 医学(系)研究科(研究院), 准教授 (40264501)
Deng Zeyi (DENG Zeyi) 琉球大学, 医学(系)研究科(研究院), 外国人客員研究員 (50723863)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 頭頸部癌 / ウイルス感染 / 生物学的活性 / 生活習慣 / 予後 / ヒト乳頭腫ウイルス / Epstein-Bar ウイルス / Epstein-Barr ウイルス |
|---|
| Outline of Final Research Achievements |
Both of p16 immunohistochemistry and PCR for detecton of HPV-DNA/HPV insitu hybridization are needed to determine human papillomavirus (HPV)-related cancer. EB virus infection was only noted in nasopharyngeal cancer of various head and neck cancers. Metabolic tumor volume in PET study was related to prognosis of oropharyngeal cancer in treatment of concurrent chemoradiotherapy. Of various causes, laryngeal cancer was affected by smoking habit, and hypopharyngeal cancer by alcohol intake. De-escalation study about HPV-related cancer is now underway for patients with oropharyngeal cancer.
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