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Prediction of primary treatment outcome and prognosis by viral infection and tumor activity in head and neck cancer

Research Project

Project/Area Number 26462610
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Otorhinolaryngology
Research InstitutionUniversity of the Ryukyus

Principal Investigator

Suzuki Mikio  琉球大学, 医学(系)研究科(研究院), 教授 (00226557)

Co-Investigator(Kenkyū-buntansha) 上原 貴行  琉球大学, 医学部附属病院, 助教 (00644402)
真栄田 裕行  琉球大学, 医学(系)研究科(研究院), 准教授 (40264501)
Deng Zeyi (DENG Zeyi)  琉球大学, 医学(系)研究科(研究院), 外国人客員研究員 (50723863)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords頭頸部癌 / ウイルス感染 / 生物学的活性 / 生活習慣 / 予後 / ヒト乳頭腫ウイルス / Epstein-Bar ウイルス / Epstein-Barr ウイルス
Outline of Final Research Achievements

Both of p16 immunohistochemistry and PCR for detecton of HPV-DNA/HPV insitu hybridization are needed to determine human papillomavirus (HPV)-related cancer. EB virus infection was only noted in nasopharyngeal cancer of various head and neck cancers. Metabolic tumor volume in PET study was related to prognosis of oropharyngeal cancer in treatment of concurrent chemoradiotherapy. Of various causes, laryngeal cancer was affected by smoking habit, and hypopharyngeal cancer by alcohol intake. De-escalation study about HPV-related cancer is now underway for patients with oropharyngeal cancer.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (23 results)

All 2016 2015 2014 Other

All Journal Article (13 results) (of which Peer Reviewed: 8 results,  Acknowledgement Compliant: 2 results,  Open Access: 3 results) Presentation (6 results) (of which Int'l Joint Research: 3 results,  Invited: 2 results) Remarks (4 results)

  • [Journal Article] Prognostic impact of pathological response to neoadjuvant chemotherapy followed by definitive surgery in sinonasal squamous cell carcinoma2016

    • Author(s)
      3.Hirakawa H, Hanai N, Ozawa T, Suzuki H, Nishikawa D, Matayoshi S, Suzuki M, Hasegawa Y
    • Journal Title

      Head Neck

      Volume: 38 Issue: S1

    • DOI

      10.1002/hed.24217

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 喉頭乳頭腫におけるヒト乳頭腫ウイルス感染と臨床経過2016

    • Author(s)
      喜友名朝則、喜瀬乗基、真栄田裕行、又吉 宣、比嘉麻乃、鈴木幹男
    • Journal Title

      喉頭

      Volume: 28 Pages: 24-30

    • NAID

      130005249916

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 頭頸部癌の診断と治療2016

    • Author(s)
      鈴木幹男
    • Journal Title

      沖縄県医師会報

      Volume: 52 Pages: 804-809

    • Related Report
      2016 Annual Research Report
  • [Journal Article] 【中咽頭癌-HPVの視点からみた大きな変化】 疫学と病態 中咽頭癌と子宮頸癌のHPVの違いは?2016

    • Author(s)
      鈴木幹男、上原貴行
    • Journal Title

      JOHNS

      Volume: 32 Pages: 287-292

    • Related Report
      2016 Annual Research Report
  • [Journal Article] 当科における下咽頭・頸部食道癌治療の妥当性に関する検討2015

    • Author(s)
      真栄田裕行,杉田早知子,喜瀬乗基,喜友名朝則,鈴木幹男
    • Journal Title

      口腔・咽頭科

      Volume: 28 Pages: 165-170

    • NAID

      130005438167

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] 頭頸部癌に対する姑息的照射治療2015

    • Author(s)
      上原貴行,真栄田裕行,山下懐,長谷川昌宏,安慶名信也,鈴木幹男
    • Journal Title

      耳鼻咽喉科臨床

      Volume: 108 Pages: 475-481

    • NAID

      130005072171

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] 喉頭癌の発症要因2015

    • Author(s)
      鈴木幹男
    • Journal Title

      JOHNS

      Volume: 31 Pages: 405-408

    • Related Report
      2015 Research-status Report
  • [Journal Article] Is there a higher prevalence of human papillomavirus infection in Chinese laryngeal cancer patients? A systematic review and meta-analysis.2014

    • Author(s)
      Zhang C, Deng Z, Chen Y, Suzuki M, Xie M.
    • Journal Title

      European Archives of Otorhinolaryngology

      Volume: epub Issue: 2 Pages: 295-303

    • DOI

      10.1007/s00405-014-3345-3

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Epstein-Barr virus and human papillomavirus infections and genotype distribution in head and neck cancers2014

    • Author(s)
      Deng, Suzuki et al
    • Journal Title

      PLoS One

      Volume: 9 Issue: 11 Pages: e113702-e113702

    • DOI

      10.1371/journal.pone.0113702

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Prediction of concurrent chemoradiotherapy outcome in advanced oropharyngeal cancer.2014

    • Author(s)
      Hasegawa M, Maeda H, Deng Z, Kiyuna A, Ganaha A, Yamashita Y, Matayoshi S, Agena S, Toita T, Uehara T, Suzuki M.
    • Journal Title

      Int J Oncol

      Volume: 45 Issue: 3 Pages: 1017-26

    • DOI

      10.3892/ijo.2014.2504

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A comprehensive evaluation of human papillomavirus positive status and p16INK4a overexpression as a prognostic biomarker in head and neck squamous cell carcinoma.2014

    • Author(s)
      Deng Z, Suzuki M, et al
    • Journal Title

      Int J Oncol

      Volume: 45 Issue: 1 Pages: 67-76

    • DOI

      10.3892/ijo.2014.2440

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 鼻副鼻腔腫瘍の診断と病理2014

    • Author(s)
      鈴木幹男
    • Journal Title

      日本耳鼻咽喉科学会会報

      Volume: 117 Pages: 1212-1215

    • NAID

      130004696910

    • Related Report
      2014 Research-status Report
  • [Journal Article] ヒト乳頭腫ウイルス感染の現状と新しい展開2014

    • Author(s)
      鈴木幹男
    • Journal Title

      日本耳鼻咽喉科学会会報

      Volume: 117 Pages: 769-774

    • NAID

      130003373053

    • Related Report
      2014 Research-status Report
  • [Presentation] Branchiogenic carcinoma with high-risk type human papillomavirus infection2016

    • Author(s)
      Suzuki, M, et al
    • Organizer
      Eurogin 2016
    • Place of Presentation
      Salzburg, Austria
    • Year and Date
      2016-06-15
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Clinical importance of HPV testing in advanced oropharyngeal carncer2016

    • Author(s)
      Suzuki M, et al
    • Organizer
      16th Japan-Korea Joint Meeting of Otorhinolaryngology, Head and Neck Surgery
    • Place of Presentation
      ハイアットリージェンシー東京,新宿区,東京都
    • Year and Date
      2016-03-28
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] HPV-related head and neck cancer2016

    • Author(s)
      Suzuki, M, et al
    • Organizer
      10th Anniversary Symposium of the Otolaryngology-Head and Neck Surgery
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 頭頸部癌におけるEpstein-Barrウイルスとヒト乳頭腫ウイルス感染と治療予後について2015

    • Author(s)
      鈴木幹男,他
    • Organizer
      日本癌治療学会
    • Place of Presentation
      京都(国立京都国際会議場・グランドプリンスホテル京都
    • Year and Date
      2015-10-29
    • Related Report
      2015 Research-status Report
  • [Presentation] Prediction of concurrent chemoradiotherapy effect in advanced oropharngeal cancer2015

    • Author(s)
      Mikio Suzuki
    • Organizer
      13th Asia-Oceania ORL-HNS Congress
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2015-03-19 – 2015-03-22
    • Related Report
      2014 Research-status Report
  • [Presentation] HPV (+) and/or p16INK4a overexpression vs HPV (-) and/or p16INK4a non-overexpression for the prognosis of HNSCC2014

    • Author(s)
      Mikio Suzuki
    • Organizer
      IFHNOS 2014
    • Place of Presentation
      New York, USA
    • Year and Date
      2014-07-27 – 2014-07-30
    • Related Report
      2014 Research-status Report
  • [Remarks] https://ent-ryukyu.jp/results.html

    • Related Report
      2016 Annual Research Report
  • [Remarks] 琉球大学医学部耳鼻咽喉科業績

    • URL

      http://ent-ryukyu.jp/results.html

    • Related Report
      2015 Research-status Report
  • [Remarks] 研究紹介

    • URL

      http://ent-ryukyu.jp/research.html

    • Related Report
      2014 Research-status Report
  • [Remarks] 業績

    • URL

      http://ent-ryukyu.jp/results.html

    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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