Analysis of carcinogenesis mechanism induced by human papillomavirus using DNA methylation as an indicator
| Project/Area Number |
26462611
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
Deng Zeyi 琉球大学, 医学(系)研究科(研究院), 外国人客員研究員 (50723863)
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| Co-Investigator(Kenkyū-buntansha) |
鈴木 幹男 琉球大学, 医学(系)研究科(研究院), 教授 (00226557)
上原 貴行 琉球大学, 医学部附属病院, 助教 (00644402)
真栄田 裕行 琉球大学, 医学(系)研究科(研究院), 准教授 (40264501)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 頭頸部癌 / human papillomavirus / 喉頭乳頭腫 / Long control region / DNAメチル化 / SMG-1 / HPV / E6とE7 / 放射線の敏感性 / LCR / メチル化 |
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| Outline of Final Research Achievements |
In this project, it was demonstrated that long control region (LCR) of HPV-16 in HPV-16 positive head and neck cancer (HNC) is often hypomethylated, and hypermethylation status of E2-binding Sites of HPV-16 frequently contributes to carcinogenesis in HNC. The extent of HPV-DNA methylation is not associated to the prognosis of HNC. Compared to HPV-DNA positive HNC, the higher level of SMG-1 mRNA expression in HPV-DNA negative HNC was observed. Lower SMG-1 mRNA expression may be associated with radiotherapy sensitivity in HNC. In addition, our findings revealed that the LCR of HPV-6 is frequently hypomethylated in laryngeal papilloma. Seven papers in English have published during 3 years of the research period.
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Report
(4 results)
Research Products
(9 results)
