| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Spasmodic dysphonia is disease of unknown that a strained or strangled, and effortful voice with breaks in pitch and phonation, but is not clear about the pathophysiology.We examined a cerebral function using functional magnetic resonance imaging to clear the pathophysiology.We intended for 12 patients and 16 healthy subjects who had a diagnosis of adducttor spasmodic dysphonia and investigated it about the resting functional brain connectivity without the phonation task. In addition, we examined the connection between the degree of the symptom, duration of symptom and the functional brain connectivity. The functional brain connectivity in the thalamus and basal ganglia (caudate nucleus) correlated with the severity of the symptom significantly high. This supported that it was the disease that was similar to the dystonia that the abnormality of the basal ganglia network was considered to be a cause till now.
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