Research of the inhibitory factors by regulation of epithelial cell polarity and organogenesis signaling in pharyngeal cancer invasion/metastasis
Project/Area Number |
26462613
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Otorhinolaryngology
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Research Institution | Sapporo Medical University |
Principal Investigator |
KONDO ATSUSHI 札幌医科大学, 医学部, 講師 (40457718)
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Co-Investigator(Kenkyū-buntansha) |
高野 賢一 札幌医科大学, 医学部, 准教授 (70404689)
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Co-Investigator(Renkei-kenkyūsha) |
KOJIMA TAKASHI 札幌医科大学, 医学部, 教授 (30260764)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | 咽頭がん / 細胞極性 / YAP / LSR / PAR3 / ASPP2 / HDAC / タイト結合 / 接着分子 / Par3 / ZEB1 / .咽頭がん |
Outline of Final Research Achievements |
The first, in pharyngeal squamous cell carcinomas (PSCC), a hippo pathway key molecule YAP which contributed to organogenesis signaling, was positive in the nuclei of all cancer cells. The changes in expression and localization of LSR (lipolysis-stimulated lipoprotein receptor) which was regulated by YAP were observed during the malignancy. In LSR-knockdown cancer cell line, upregulation of cell invasion and migration was observed. The next, epithelial cell polarity molecules PAR3 and the regulator ASPP2 (apoptosis stimulating proteins of p53-2) were upregulated in PSCC than dysplasia. Inhibitors of HDACs (histone deacetylases) which upregulated in PSCC, induced expression of PAR3 and ASPP2 and inhibited cancer cell invasion and migration. In conclusion, the regulation of epithelial cell polarity molecules LSR, PAR3 and ASPP2 and organogenesis signaling YAP may be an important to prevent invasion/metastasis of PSCC.
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Report
(4 results)
Research Products
(29 results)
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[Journal Article] Dysregulation of junctional adhesion molecule-A via p63/GATA-3 in head and neck squamous cell carcinoma2016
Author(s)
Kakuki T, Kurose M, Takano K, Kondoh A, Obata K, Nomura K, Miyata R, Kaneko Y, Konno T, Takahashi S, Hatakeyama T, Kohno T, Himi T Kojima T.
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Journal Title
Oncotarget
Volume: 7(23)
Pages: 33887-33900
Related Report
Peer Reviewed
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[Journal Article] 耳下腺癌肉腫の1例2016
Author(s)
高橋希, 高野賢一, 大國毅, 黒瀬誠, 近藤敦, 氷見徹夫
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Journal Title
口腔・咽頭科
Volume: 29(1)
Pages: 127-132
NAID
Related Report
Peer Reviewed
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[Journal Article] The behavior and role of lipolysis-stimulated lipoprotein receptor, a component of tricellular tight junctions, in head and neck squamous cell carcinomas2016
Author(s)
Takano K, Kakuki T, Obata K, Nomura K, Miyata R, Kondo A, Kurose M, Kakiuch A, Kaneko Y, Kohno T, Himi T, Kojima T
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Journal Title
Anticancer Research
Volume: 36
Pages: 5895-5940
Related Report
Peer Reviewed
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[Journal Article] Junctional Adhesion Molecule-A in Head and Neck Squamous Cell Carcinoma.2016
Author(s)
Kurose M, Kakuki T, Takano K, Kondo A, Obata K, Nomura K, Miyata R, Kaneko Y, Konno T, Kohno T, Kojima T, Himi T
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Journal Title
Adv. Otorhinolaryngol
Volume: 77
Pages: 92-97
Related Report
Peer Reviewed
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[Journal Article] Dysregulation of junctional adhesion molecule-A via p63/GATA-3 in head and neck squamous cell carcinoma.2016
Author(s)
Kakuki T, Kurose M, TakanoK, Kondoh A, Obata K, Nomura K, Miyata R, Kaneko Y, Konno T, Takahashi S, Hatakeyama T, Kohno T, Himi T, Kojima T.
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Journal Title
Oncotarget
Volume: .
Issue: 23
Pages: 1-14
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] 頭頸部扁平上皮癌におけるp63/GATA-3経路によるタイト結合分子JAM-Aの発現メカニズムの解明2015
Author(s)
角木拓也, 黒瀬 誠, 高野賢一, 近藤 敦, 小幡和史, 野村一顕, 宮田 遼, 金子躍人, 金野 匠, 高橋駿太, 畠山翔翼, 幸野貴之, 氷見徹夫, 小島 隆
Organizer
第47回日本臨床分子形態学会総会・学術集会
Place of Presentation
長崎大学医学部良順会館(長崎市)
Year and Date
2015-09-18
Related Report
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[Presentation] 頭頸部扁平上皮癌におけるp63/GATA-3経路を介したタイト結合分子JAM-Aの発現調節機構2015
Author(s)
角木拓也, 黒瀬 誠, 高野賢一, 近藤 敦, 小幡和史, 野村一顕, 宮田 遼, 金野 匠, 高橋駿太, 畠山翔翼, 幸野貴之, 氷見徹夫, 小島 隆
Organizer
第67 回日本細胞生物学会大会
Place of Presentation
タワーホール船堀(東京都江戸川区)
Year and Date
2015-06-30
Related Report
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