The study of the tracheal reconstruction effect using a new artificial trachea

• Project/Area Number: 26462615
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Fukushima Medical University
• Principal Investigator: Tada Yasuhiro 福島県立医科大学, 医学部, 准教授 (70363760)
• Co-Investigator(Kenkyū-buntansha): 竹澤 俊明 国立研究開発法人農業生物資源研究所, その他部局等, 上級研究員 (50301297)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 再生医療 / 気管食道科 / 人工気管 / 耳鼻咽喉科 / 人工気管固定方法 / 気管内腔の形態 / 気管欠損モデルの作製 / 上皮形成促進効果

Outline of Final Research Achievements

The study of the tracheal reconstruction effect using a new artificial trachea.A study of the tracheal reconstruction.We developed a new artificial trachea.Material is collagen sponge and polypropylene and Vitrigel.Made the trachea defect model of the rabbit to transplant it.We were able to make a defect of 10*5 millimeters to a tracheal.We studied a method to transplant an artificial trachea.
Results:It was recognized that an artificial trachea and the tracheal suture method did not influence epithelial reproduction.A good suture method is to sew up an artificial trachea and the trachea at short distance.Because the trachea does not transform it.

Research Products

• [Presentation] 外傷性気管狭窄症に対する人工気管を用いた気管再建術 (2016)
  • Author(s): 多田靖宏
  • Organizer: 日本気管食道科学会
  • Place of Presentation: 東京都
  • Year and Date: 2016-11-07
• [Presentation] Effects of artificial tracheal fixation on tracheal epithelial regeneration and prevention of tracheal stenosis (2016)
  • Author(s): Yuta Nakaegawa, Yasuhiro Tada, Ryosuke Nakamura, Akiko Tani, Koichi omori
  • Organizer: American Laryngological Association
  • Place of Presentation: シカゴ
  • Year and Date: 2016-05-18
  • Int'l Joint Research
• [Presentation] The examination of the fixed method of the artificial trachea (2016)
  • Author(s): Yasuhiro Tada, Yuta Nakaegawa, Ryosuke Nakamura, Akiko Tani, Koichi Omori
  • Organizer: East Asian Conference on Phonosurgery
  • Place of Presentation: 熊本市
  • Year and Date: 2016-03-04
• [Presentation] 人工気管の臨床応用と実用化 (2015)
  • Author(s): 多田靖宏
  • Organizer: 日本気管食道科学会
  • Place of Presentation: 福島市
  • Year and Date: 2015-11-19
• [Presentation] コラーゲンスポンジにコラーゲンビトリゲル膜を重層化した人工気管による喉頭気管再生の試み (2015)
  • Author(s): 多田靖宏
  • Organizer: 日本再生医療学会
  • Place of Presentation: 横浜市
  • Year and Date: 2015-03-19 – 2015-03-21
• [Presentation] 気管を再生する医療技術の開発状況 (2014)
  • Author(s): 多田靖宏
  • Organizer: 日本組織培養学学会
  • Place of Presentation: 東京都
  • Year and Date: 2014-05-31
  • Invited