Elucidation of cancer invasion / metastasis mechanism associated with abnormal glucose metabolism and activation of EMT signaling in head and neck cancer
Project/Area Number |
26462617
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Otorhinolaryngology
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Research Institution | Nara Medical University |
Principal Investigator |
Ichiro Ota 奈良県立医科大学, 医学部, 講師 (00326323)
|
Co-Investigator(Kenkyū-buntansha) |
高橋 昭久 群馬大学, 重粒子線医学推進機構, 教授 (60275336)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 癌幹細胞 / 浸潤・転移 / EMT / 糖尿病 |
Outline of Final Research Achievements |
Abnormal glucose metabolism in cancer cells is known to be a major factor in cancer development. As a condition of diabetes, we investigated whether carbohydrate-specific carbohydrate metabolism abnormality induced EMT (Epithelial-Mesenchymal Transition) in hyperglycemic state promotes activation of cancer stem cells and enhances cancer invasion and metastasis. In addition, it also suggested that hyperglycemic state could affect the activation of cancer stem cells. Moreover, It was suggested that hyperglycaemic cancer cells have increased invasion and metastasis in vivo.
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Report
(4 results)
Research Products
(9 results)
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[Journal Article] Snail-induced EMT promotes cancer stem cell-like properties in head and neck cancer cells.2016
Author(s)
1.Ota I, Masui T, Kurihara M, Yook JI, Mikami S, Kimura T, Shimada K, Konishi N, Yane K, Yamanaka T, Kitahara T
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Journal Title
Oncol Rep
Volume: 35
Pages: 261-266
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Helicobacter pylori CagA promotes Snail-mediated epithelial-mesenchymal transition by reducing GSK-3 activity.2014
Author(s)
Lee DG, Kim HS, Lee YS, Kim S, Cha SY, Ota I, Kim NH, Cha YH, Yang DH, Lee Y, Park GJ, Yook JI, Lee YC.
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Journal Title
Nat Commun
Volume: 5
Issue: 1
Pages: 4423-4423
DOI
Related Report
Peer Reviewed / Open Access
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