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Elucidation of cancer invasion / metastasis mechanism associated with abnormal glucose metabolism and activation of EMT signaling in head and neck cancer

Research Project

Project/Area Number 26462617
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Otorhinolaryngology
Research InstitutionNara Medical University

Principal Investigator

Ichiro Ota  奈良県立医科大学, 医学部, 講師 (00326323)

Co-Investigator(Kenkyū-buntansha) 高橋 昭久  群馬大学, 重粒子線医学推進機構, 教授 (60275336)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords癌幹細胞 / 浸潤・転移 / EMT / 糖尿病
Outline of Final Research Achievements

Abnormal glucose metabolism in cancer cells is known to be a major factor in cancer development. As a condition of diabetes, we investigated whether carbohydrate-specific carbohydrate metabolism abnormality induced EMT (Epithelial-Mesenchymal Transition) in hyperglycemic state promotes activation of cancer stem cells and enhances cancer invasion and metastasis. In addition, it also suggested that hyperglycemic state could affect the activation of cancer stem cells. Moreover, It was suggested that hyperglycaemic cancer cells have increased invasion and metastasis in vivo.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (9 results)

All 2017 2016 2015 2014

All Journal Article (4 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 4 results,  Open Access: 4 results,  Acknowledgement Compliant: 2 results) Presentation (5 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Effect of resveratrol on cancer progression through the REG Ⅲ expression pathway in head and neck cancer cells.2016

    • Author(s)
      Mikami S, Ota I, Masui T, Itaya-Hironaka A, Shobatake R, Okamoto H, Takasawa S, Kitahara T
    • Journal Title

      Int J Oncol.

      Volume: 49 Issue: 4 Pages: 1553-1560

    • DOI

      10.3892/ijo.2016.3664

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Snail-induced EMT promotes cancer stem cell-like properties in head and neck cancer cells.2016

    • Author(s)
      1.Ota I, Masui T, Kurihara M, Yook JI, Mikami S, Kimura T, Shimada K, Konishi N, Yane K, Yamanaka T, Kitahara T
    • Journal Title

      Oncol Rep

      Volume: 35 Pages: 261-266

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Snail-induced epithelial-mesenchymal transition promotes cancer stem cell-like phenotype in head and neck cancer cells2014

    • Author(s)
      Masui T, Ota I, Yook JI, et al.
    • Journal Title

      Int J Oncol.

      Volume: 44 Issue: 3 Pages: 693-699

    • DOI

      10.3892/ijo.2013.2225

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Helicobacter pylori CagA promotes Snail-mediated epithelial-mesenchymal transition by reducing GSK-3 activity.2014

    • Author(s)
      Lee DG, Kim HS, Lee YS, Kim S, Cha SY, Ota I, Kim NH, Cha YH, Yang DH, Lee Y, Park GJ, Yook JI, Lee YC.
    • Journal Title

      Nat Commun

      Volume: 5 Issue: 1 Pages: 4423-4423

    • DOI

      10.1038/ncomms5423

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] The mechanism of cancer invasion and metastasis through EMT signaling in head and neck cancer2017

    • Author(s)
      Ichiro Ota, Takashi Masui, Jong-In Yook, Shinji Mikami, Takahiro Kimura, Hirokazu Uemura, Hideyuki Okamoto and Tadashi Kitahara
    • Organizer
      5th Congress of Asian Society of Head and Neck Oncology
    • Place of Presentation
      Bali, Indonesia
    • Year and Date
      2017-03-23
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Helicobacter Pylori CagA Promotes Snail-mediated Epithelial-mesenchymal Transition in Cancer Cells2015

    • Author(s)
      Ota I, Masui T, Mikami S, Uemura H, Okamoto T, Kitahara T
    • Organizer
      第4回アジア頭頸部癌学会
    • Place of Presentation
      神戸市
    • Year and Date
      2015-06-03
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Snailによる癌幹細胞様特性の獲得と維持2014

    • Author(s)
      桝井貴史、太田一郎、三上慎司、家根旦有、山中敏彰、細井裕司
    • Organizer
      日本頭頸部癌学会
    • Place of Presentation
      東京都
    • Year and Date
      2014-06-12 – 2014-06-13
    • Related Report
      2014 Research-status Report
  • [Presentation] Snailによる上皮間葉移行の誘導と癌幹細胞様特性の獲得2014

    • Author(s)
      桝井貴史、太田一郎、山中敏彰、細井裕司
    • Organizer
      日本耳鼻咽喉科学会総会
    • Place of Presentation
      福岡市
    • Year and Date
      2014-05-16 – 2014-05-18
    • Related Report
      2014 Research-status Report
  • [Presentation] Snail-induced epithelial-mesenchymal transition generates the properties of cancer stem cells in head and neck cancer cells2014

    • Author(s)
      Ichiro Ota, Takashi Masui, Shinji Mikami, Toshiaki Yamanaka, Hiroshi Hosoi.
    • Organizer
      AACR
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2014-04-05 – 2014-04-09
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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