Elucidation of cancer invasion / metastasis mechanism associated with abnormal glucose metabolism and activation of EMT signaling in head and neck cancer

• Project/Area Number: 26462617
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Nara Medical University
• Principal Investigator: Ichiro Ota 奈良県立医科大学, 医学部, 講師 (00326323)
• Co-Investigator(Kenkyū-buntansha): 高橋 昭久 群馬大学, 重粒子線医学推進機構, 教授 (60275336)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 癌幹細胞 / 浸潤・転移 / EMT / 糖尿病

Outline of Final Research Achievements

Abnormal glucose metabolism in cancer cells is known to be a major factor in cancer development. As a condition of diabetes, we investigated whether carbohydrate-specific carbohydrate metabolism abnormality induced EMT (Epithelial-Mesenchymal Transition) in hyperglycemic state promotes activation of cancer stem cells and enhances cancer invasion and metastasis. In addition, it also suggested that hyperglycemic state could affect the activation of cancer stem cells. Moreover, It was suggested that hyperglycaemic cancer cells have increased invasion and metastasis in vivo.

Research Products

• [Journal Article] Effect of resveratrol on cancer progression through the REG Ⅲ expression pathway in head and neck cancer cells. (2016)
  • Author(s): Mikami S, Ota I, Masui T, Itaya-Hironaka A, Shobatake R, Okamoto H, Takasawa S, Kitahara T
  • Journal Title: Int J Oncol. Volume: ４９ Issue: 4 Pages: 1553-1560
  • DOI: 10.3892/ijo.2016.3664
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Snail-induced EMT promotes cancer stem cell-like properties in head and neck cancer cells. (2016)
  • Author(s): 1.Ota I, Masui T, Kurihara M, Yook JI, Mikami S, Kimura T, Shimada K, Konishi N, Yane K, Yamanaka T, Kitahara T
  • Journal Title: Oncol Rep Volume: 35 Pages: 261-266
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Snail-induced epithelial-mesenchymal transition promotes cancer stem cell-like phenotype in head and neck cancer cells (2014)
  • Author(s): Masui T, Ota I, Yook JI, et al.
  • Journal Title: Int J Oncol. Volume: 44 Issue: 3 Pages: 693-699
  • DOI: 10.3892/ijo.2013.2225
  • Peer Reviewed / Open Access
• [Journal Article] Helicobacter pylori CagA promotes Snail-mediated epithelial-mesenchymal transition by reducing GSK-3 activity. (2014)
  • Author(s): Lee DG, Kim HS, Lee YS, Kim S, Cha SY, Ota I, Kim NH, Cha YH, Yang DH, Lee Y, Park GJ, Yook JI, Lee YC.
  • Journal Title: Nat Commun Volume: 5 Issue: 1 Pages: 4423-4423
  • DOI: 10.1038/ncomms5423
  • Peer Reviewed / Open Access
• [Presentation] The mechanism of cancer invasion and metastasis through EMT signaling in head and neck cancer (2017)
  • Author(s): Ichiro Ota, Takashi Masui, Jong-In Yook, Shinji Mikami, Takahiro Kimura, Hirokazu Uemura, Hideyuki Okamoto and Tadashi Kitahara
  • Organizer: 5th Congress of Asian Society of Head and Neck Oncology
  • Place of Presentation: Bali, Indonesia
  • Year and Date: 2017-03-23
  • Int'l Joint Research
• [Presentation] Helicobacter Pylori CagA Promotes Snail-mediated Epithelial-mesenchymal Transition in Cancer Cells (2015)
  • Author(s): Ota I, Masui T, Mikami S, Uemura H, Okamoto T, Kitahara T
  • Organizer: 第4回アジア頭頸部癌学会
  • Place of Presentation: 神戸市
  • Year and Date: 2015-06-03
  • Int'l Joint Research
• [Presentation] Snailによる癌幹細胞様特性の獲得と維持 (2014)
  • Author(s): 桝井貴史、太田一郎、三上慎司、家根旦有、山中敏彰、細井裕司
  • Organizer: 日本頭頸部癌学会
  • Place of Presentation: 東京都
  • Year and Date: 2014-06-12 – 2014-06-13
• [Presentation] Snailによる上皮間葉移行の誘導と癌幹細胞様特性の獲得 (2014)
  • Author(s): 桝井貴史、太田一郎、山中敏彰、細井裕司
  • Organizer: 日本耳鼻咽喉科学会総会
  • Place of Presentation: 福岡市
  • Year and Date: 2014-05-16 – 2014-05-18
• [Presentation] Snail-induced epithelial-mesenchymal transition generates the properties of cancer stem cells in head and neck cancer cells (2014)
  • Author(s): Ichiro Ota, Takashi Masui, Shinji Mikami, Toshiaki Yamanaka, Hiroshi Hosoi.
  • Organizer: AACR
  • Place of Presentation: San Diego, USA
  • Year and Date: 2014-04-05 – 2014-04-09