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Development and clinical application of novel diagnostic and therapeutic procedures for head and neck cancer using micro bubbles and nanobabbles

Research Project

Project/Area Number 26462619
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Otorhinolaryngology
Research InstitutionIwate Medical University

Principal Investigator

Shiga Kiyoto  岩手医科大学, 医学部, 教授 (10187338)

Co-Investigator(Kenkyū-buntansha) 齋藤 大輔  岩手医科大学, 医学部, 助教 (40722715)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords頭頸部癌 / 造影超音波 / マイクロバブル / ナノバブル / 頸部リンパ節転移 / 造影超音波診断 / リンパ節転移
Outline of Final Research Achievements

1) We developed and sophisticated an Image-analyzing soft-ware for contrast-enhanced ultrasonography (CEUS) to detect metastatic lymph nodes. 2) We organized "Japan Head and Neck Contrast-enhanced Ultrasonography Research Group" and are performing multi-institutional study called "The study to examine efficacy of contrast-enhanced ultrasonography for the metastatic lymph nodes of head and neck cancer patients". 3) We found several new phenomenon by comparing preoperative CEUS images and histopathological images of postoperative surgical specimens. 4) It was indicated that densities of micro-capillary vessels inside the metastatic lymph nodes may be the indicator for the efficacy of chemo-radiotherapy by pre-, mid-, post-therapeutic CEUS examination.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (4 results)

All 2017 2016 2015 2014

All Presentation (4 results) (of which Int'l Joint Research: 1 results)

  • [Presentation] Efficacy of contrast-enhanced ultrasonography compared with color Doppler imaging in metastatic cervical lymph nodes of head and neck cancer patients2017

    • Author(s)
      Daisuke Saitoh
    • Organizer
      AIUM annual meeting
    • Place of Presentation
      フロリダ
    • Year and Date
      2017-03-25
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 造影超音波の頭頸部がんへの臨床応用2016

    • Author(s)
      志賀清人
    • Organizer
      日本超音波医学会総会
    • Place of Presentation
      京都
    • Year and Date
      2016-05-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] 乳腺・甲状腺・頭頸部体表領域のリンパ節転移診断 頭頸部癌の頸部リンパ節転移診断における超音波の役割2015

    • Author(s)
      齋藤大輔
    • Organizer
      乳腺甲状腺超音波医学会
    • Place of Presentation
      グランドプリンスホテル新高輪
    • Year and Date
      2015-05-24
    • Related Report
      2015 Research-status Report
  • [Presentation] 造影超音波を用いた頭頸部癌頸部リンパ節転移の検出2014

    • Author(s)
      志賀清人
    • Organizer
      日本超音波医学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-05-09
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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