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Experimental application of piezoelectric actuator-driven pulsed water jets in retinal vein occlusion surgery

Research Project

Project/Area Number 26462629
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Ophthalmology
Research InstitutionTohoku University

Principal Investigator

Kunikata Hiroshi  東北大学, 医学系研究科, 准教授 (40361092)

Co-Investigator(Kenkyū-buntansha) 中川 敦寛  東北大学, 医学系研究科, 講師 (10447162)
田中 佑治  国立研究開発法人理化学研究所, 情報基盤センター, センター研究員 (40625513)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords硝子体手術 / パルスジェット / 網膜静脈閉塞 / 網膜静脈閉塞症
Outline of Final Research Achievements

We found that at 0.025-ml/min, IOP stayed below 40 mmHg even after 3 min. Moreover, we found that a 0.025 ml/min ADPJ stream was stable at a pulse frequency of 10Hz, and that at this flow rate/frequency the ADPJ pressure was closely correlated with the applied voltage. The minimum voltage and distance to achieve intravenous displacement of the blood column (DBC) without causing retinal tearing or hemorrhage were 40 V and 0.5 mm, respectively. Furthermore, at this voltage (40V), consecutive OCT measurements revealed that this inner retinal swelling resolved within 1 week. Histological examination of the enucleated eyes 7 days after ADPJ massage showed that retinal areas near the massaged vessels were similar to areas near untreated vessels. With an appropriate flow rate and surgical time, ADPJ successfully induced massage of the retinal vessels and intravenous DBC while maintaining safe IOP and not causing retinal complications.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (11 results)

All 2016 2015 2014

All Journal Article (8 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 8 results,  Acknowledgement Compliant: 7 results,  Open Access: 3 results) Presentation (3 results) (of which Invited: 2 results)

  • [Journal Article] Recent Clinical Applications of Laser Speckle Flowgraphy in Eyes with Retinal Disease2016

    • Author(s)
      Kunikata H, Nakazawa T.
    • Journal Title

      Asia Pac J Ophthalmol (Phila)

      Volume: 5 Issue: 2 Pages: 151-8

    • DOI

      10.1097/apo.0000000000000160

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Anterior chamber aqueous flare and optic nerve microcirculation in eyes with rhegmatogenous retinal detachment2016

    • Author(s)
      Yui R, Kunikata H, Aizawa N, Nakazawa T.
    • Journal Title

      Acta Ophthalmol

      Volume: 94 Issue: 6

    • DOI

      10.1111/aos.12970

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Age- and Sex-Dependency of Laser Speckle Flowgraphy Measurements of Optic Nerve Vessel Microcirculation.2016

    • Author(s)
      Aizawa N, Kunikata H, Nitta F, Shiga Y, Omodaka K, Tsuda S, Nakazawa T.
    • Journal Title

      PLoS One

      Volume: 11 Issue: 2 Pages: e0148812-e0148812

    • DOI

      10.1371/journal.pone.0148812

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Retinal Pigment Epithelium Hyperplasia After Unsuccessful Surgery for Macular Hole2016

    • Author(s)
      Imadome N, Kunikata H, Asano S, Nakazawa T.
    • Journal Title

      Ophthalmic Surg Lasers Imaging Retina

      Volume: 47 Issue: 3 Pages: 284-6

    • DOI

      10.3928/23258160-20160229-13

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] The relationship between advanced glycation end products and ocular circulation in type 2 diabetes2016

    • Author(s)
      Hashimoto K, Kunikata H, Yasuda M, Ito A, Aizawa N, Sawada S, Kondo K, Satake C, Takano Y, Nishiguchi KM, Katagiri H, Nakazawa T.
    • Journal Title

      J Diabetes Complications

      Volume: 30 Issue: 7 Pages: 1371-7

    • DOI

      10.1016/j.jdiacomp.2016.04.024

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Heads-up Macular Surgery with a 27-Gauge Microincision Vitrectomy System and Minimal Illumination2016

    • Author(s)
      Kunikata H, Abe T, Nakazawa T.
    • Journal Title

      Case Rep Ophthalmol.

      Volume: 29 Issue: 3 Pages: 265-269

    • DOI

      10.1159/000452993

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Intraoperative Optical Coherence Tomography-Assisted 27-Gauge Vitrectomy in Eyes with Vitreoretinal Diseases2015

    • Author(s)
      Kunikata H, Nakazawa T
    • Journal Title

      Case Rep Ophthalmol

      Volume: 6 Issue: 2 Pages: 216-222

    • DOI

      10.1159/000437014

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Experimental Application of Piezoelectric Actuator-Driven Pulsed Water Jets in Retinal Vascular Surgery2014

    • Author(s)
      Kunikata H, Tanaka Y, Aizawa N, Nakagawa A, Tominaga T, Nakazawa T.
    • Journal Title

      Transl Vis Sci Technol

      Volume: 3 Issue: 6 Pages: 1-8

    • DOI

      10.1167/tvst.3.6.10

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] パルスジェット原理の硝子体手術応用2016

    • Author(s)
      國方彦志
    • Organizer
      第120回日本眼科学会総会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] シンポジウム~臨床検体から網膜硝子体疾患を理解する~ 硝子体の抗酸化メタボローム解析2015

    • Author(s)
      國方彦志
    • Organizer
      第69回日本臨床眼科学会
    • Place of Presentation
      名古屋(名古屋国際会議場)
    • Year and Date
      2015-10-24
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] The application of pulsed water jets in vitreoretinal surgery and relevant retinal findings2015

    • Author(s)
      Hiroshi Kunikata, Yuji Tanaka, Naoko Aizawa, Atsuhiro Nakagawa, Teiji Tominaga, and Toru Nakazawa
    • Organizer
      Asia-ARVO
    • Place of Presentation
      横浜市 パシフィコ横浜
    • Year and Date
      2015-02-19
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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