| Project/Area Number |
26462629
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Ophthalmology
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
中川 敦寛 東北大学, 医学系研究科, 講師 (10447162)
田中 佑治 国立研究開発法人理化学研究所, 情報基盤センター, センター研究員 (40625513)
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | 硝子体手術 / パルスジェット / 網膜静脈閉塞 / 網膜静脈閉塞症 |
|---|
| Outline of Final Research Achievements |
We found that at 0.025-ml/min, IOP stayed below 40 mmHg even after 3 min. Moreover, we found that a 0.025 ml/min ADPJ stream was stable at a pulse frequency of 10Hz, and that at this flow rate/frequency the ADPJ pressure was closely correlated with the applied voltage. The minimum voltage and distance to achieve intravenous displacement of the blood column (DBC) without causing retinal tearing or hemorrhage were 40 V and 0.5 mm, respectively. Furthermore, at this voltage (40V), consecutive OCT measurements revealed that this inner retinal swelling resolved within 1 week. Histological examination of the enucleated eyes 7 days after ADPJ massage showed that retinal areas near the massaged vessels were similar to areas near untreated vessels. With an appropriate flow rate and surgical time, ADPJ successfully induced massage of the retinal vessels and intravenous DBC while maintaining safe IOP and not causing retinal complications.
|
