The development of critical hydrogel as an artificial vitreous body
Project/Area Number |
26462631
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Ophthalmology
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Research Institution | University of Tsukuba |
Principal Investigator |
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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Keywords | 人工硝子体 / ハイドロゲル / 網膜剥離 / 硝子体 |
Outline of Final Research Achievements |
Degradation-induced swelling in implanted hydrogels can cause severe adverse reactions to surrounding tissues. Here, we report a new class of hydrogel with extremely low swelling pressure, and demonstrate its use as an artificial vitreous body. The hydrogel has ultralow polymer content, low cytotoxicity, and forms in situ in 10 minutes via the crosslinking of clusters of highly branched polymers of tetra-armed poly(ethylene glycol) pre-polymers. After injection and gelation in the eyes of rabbits, the hydrogel functioned as an artificial vitreous body for over a year without adverse effects, and proved effective for the treatment of retinal detachment. The properties of the cluster hydrogel make it a promising candidate as an infill biomaterial for a range of biomedical applications.
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Report
(4 results)
Research Products
(10 results)
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[Journal Article] Fast-forming hydrogels with ultralow polymeric component as an artificial vitreous body.2017
Author(s)
Kaori Hayashi, Fumiki Okamoto, Sujin Hoshi, Takuya Katashima, Denise C. Zujur, Xiang Li, Mitsuhiro Shibayama, Elliot P. Gilbert, Ung-il Chung, Shinsuke Ohba, Tetsuro Oshika, Takamasa Sakai.
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Journal Title
Nature Biomedical Engineering.
Volume: 1
Related Report
Peer Reviewed
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