| Project/Area Number |
26462632
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
HIGASHIDE Tomomi 金沢大学, 附属病院, 講師 (20291370)
OHKUBO Shinji 金沢大学, 医学系, 協力研究員 (90362003)
NITTA kouji 金沢大学, 医学系, 協力研究員 (10260556)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | myopic glaucoma / disc hemorrhage / open angle glaucoma / glaucoma progresshion / high myopia / visual field progression / 強度近視眼緑内障 / OCT Angiography / 視神経乳頭の血管障害 / 視神経乳頭血 / 強度近視 / 正常眼圧緑内障 / 原発開放隅角緑内障 / 乳頭出血 / 乳頭周囲網脈絡膜萎縮 / 近視緑内障 / 緑内障性視神経症 / 近視視神経症 |
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| Outline of Final Research Achievements |
We clarify differences between highly myopic and non-myopic primary open-angle glaucoma (POAG) patients, including normal-tension glaucoma patients.
We analyzed 53 highly myopic and 93 non-myopic POAG patients. The cumulative probability of non-progression of visual field (VF) loss was significantly greater in the highly myopic group than in the non-myopic group (P=0.0142). The occurrence of disc hemorrhage (DH) of the non-myopic group was significantly greater than the highly myopic group (P=0.0311). The cumulative probability of DH was significantly greater in the non-myopic group than in the highly myopic group (P=0.0413).Highly myopic POAG is considered a combination of myopic optic neuropathy （MON) and glaucomatous optic neuropathy (GON). If GON is predominant, it has frequent DH and more progressive VF loss. However, when the MON is predominant, it has less DH, and less progressive VF loss.
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