| Project/Area Number |
26462637
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
辻川 明孝 京都大学, 医学研究科, 教授 (40402846)
大石 明生 京都大学, 医学研究科, 特定病院助教 (50572955)
宇治 彰人 京都大学, 医学研究科, 特定助教 (60534302)
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| Co-Investigator(Renkei-kenkyūsha) |
OISHI Akio 京都大学, 大学院医学研究科眼科学, 助教 (50572955)
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| Research Collaborator |
UJI Akihito 京都大学, 大学院医学研究科眼科学, 助教 (60534302)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 糖尿病網膜症 / 光干渉断層計 / OCT angiography / 超広角眼底写真 / 補償光学走査型レーザー検眼鏡 / 無灌流域 / 糖尿病黄斑浮腫 / 視細胞 / 神経網膜 / 眼底イメージング / 眼底自発蛍光 |
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| Outline of Final Research Achievements |
We found that white dots in the ultrawide field fundus photograph or no boundary between the nerve fiber layer and ganglion cell layer in the optical coherence tomography (OCT) are delineated within the nonperfused areas in diabetic retinopathy (DR). Further, we reported inner retinal spots with inverted OCT reflectivity as a novel lesion on OCT images. Further investigation using novel imaging devices, e.g., OCT angiography and adaptive optics scanning laser ophthalmoscope revealed the pathogenesis in the nonperfused areas and the circulation disturbance or thickened vascular walls. Novel parameters on fundus imaging allowed us to identify the predictors of the responsiveness to anti-VEGF treatment or ocular steroid injections in diabetic macular edema.
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