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Development of integrative methods to evaluate diabetic retinopathy using noninvasive in vivo imaging

Research Project

Project/Area Number 26462637
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Ophthalmology
Research InstitutionKyoto University

Principal Investigator

MURAKAMI TOMOAKI  京都大学, 医学研究科, 助教 (50549095)

Co-Investigator(Kenkyū-buntansha) 辻川 明孝  京都大学, 医学研究科, 教授 (40402846)
大石 明生  京都大学, 医学研究科, 特定病院助教 (50572955)
宇治 彰人  京都大学, 医学研究科, 特定助教 (60534302)
Co-Investigator(Renkei-kenkyūsha) OISHI Akio  京都大学, 大学院医学研究科眼科学, 助教 (50572955)
Research Collaborator UJI Akihito  京都大学, 大学院医学研究科眼科学, 助教 (60534302)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords糖尿病網膜症 / 光干渉断層計 / OCT angiography / 超広角眼底写真 / 補償光学走査型レーザー検眼鏡 / 無灌流域 / 糖尿病黄斑浮腫 / 視細胞 / 神経網膜 / 眼底イメージング / 眼底自発蛍光
Outline of Final Research Achievements

We found that white dots in the ultrawide field fundus photograph or no boundary between the nerve fiber layer and ganglion cell layer in the optical coherence tomography (OCT) are delineated within the nonperfused areas in diabetic retinopathy (DR). Further, we reported inner retinal spots with inverted OCT reflectivity as a novel lesion on OCT images. Further investigation using novel imaging devices, e.g., OCT angiography and adaptive optics scanning laser ophthalmoscope revealed the pathogenesis in the nonperfused areas and the circulation disturbance or thickened vascular walls. Novel parameters on fundus imaging allowed us to identify the predictors of the responsiveness to anti-VEGF treatment or ocular steroid injections in diabetic macular edema.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (40 results)

All 2017 2016 2015 2014

All Journal Article (23 results) (of which Int'l Joint Research: 8 results,  Peer Reviewed: 23 results,  Open Access: 4 results) Presentation (17 results) (of which Int'l Joint Research: 7 results)

  • [Journal Article] INFLUENCE OF VITRECTOMY SURGERY ON THE INTEGRITY OF OUTER RETINAL LAYERS IN DIABETIC MACULAR EDEMA.2017

    • Author(s)
      Uji A, Murakami T, Suzuma K, Yoshitake S, Arichika S, Ghashut R, Fujimoto M, Yoshimura N.
    • Journal Title

      Retina

      Volume: 印刷中 Issue: 1 Pages: 163-172

    • DOI

      10.1097/iae.0000000000001519

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] EVALUATION OF MACULAR ISCHEMIA IN EYES WITH BRANCH RETINAL VEIN OCCLUSION: An Optical Coherence Tomography Angiography Study.2017

    • Author(s)
      Kadomoto S, Muraoka Y, Ooto S, Miwa Y, Iida Y, Suzuma K, Murakami T, Ghashut R, Tsujikawa A, Yoshimura N.
    • Journal Title

      Retina

      Volume: 印刷中 Issue: 2 Pages: 272-282

    • DOI

      10.1097/iae.0000000000001541

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ASSOCIATIONS BETWEEN MACULAR EDEMA AND CIRCULATORY STATUS IN EYES WITH RETINAL VEIN OCCLUSION: An Adaptive Optics Scanning Laser Ophthalmoscopy Study.2017

    • Author(s)
      Iida Y, Muraoka Y, Uji A, Ooto S, Murakami T, Suzuma K, Tsujikawa A, Arichika S, Takahashi A, Miwa Y, Yoshimura N.
    • Journal Title

      Retina

      Volume: 印刷中 Issue: 10 Pages: 1896-1904

    • DOI

      10.1097/iae.0000000000001433

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Correlation of retinal arterial wall thickness with atherosclerosis predictors in type 2 diabetes without clinical retinopathy.2017

    • Author(s)
      Arichika S, Uji A, Murakami T, Suzuma K, Gotoh N, Yoshimura N.
    • Journal Title

      Br J Ophthalmol

      Volume: 101 Issue: 1 Pages: 69-74

    • DOI

      10.1136/bjophthalmol-2016-309612

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ASSOCIATION BETWEEN RETINAL HEMORRHAGIC PATTERNS AND PERFUSION STATUS IN EYES WITH ACUTE CENTRAL RETINAL VEIN OCCLUSION.2017

    • Author(s)
      Muraoka Y, Uji A, Tsujikawa A, Murakami T, Ooto S, Suzuma K, Takahashi A, Iida Y, Miwa Y, Hata M, Yoshimura N.
    • Journal Title

      Retina

      Volume: 37 Issue: 3 Pages: 500-508

    • DOI

      10.1097/iae.0000000000001196

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RANIBIZUMAB FOR MACULAR EDEMA AFTER BRANCH RETINAL VEIN OCCLUSION: One Initial Injection Versus Three Monthly Injections.2017

    • Author(s)
      Miwa Y, Muraoka Y, Osaka R, Ooto S, Murakami T, Suzuma K, Takahashi A, Iida Y, Yoshimura N, Tsujikawa A.
    • Journal Title

      Retina

      Volume: 37 Issue: 4 Pages: 702-709

    • DOI

      10.1097/iae.0000000000001224

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] White Dots as a Novel Marker of Diabetic Retinopathy Severity in Ultrawide Field Imaging.2016

    • Author(s)
      Dodo Y, Murakami T, Unoki N, Ogino K, Uji A, Yoshitake S, Yoshimura N.
    • Journal Title

      PLoS One

      Volume: 11 Issue: 11 Pages: e0165906-e0165906

    • DOI

      10.1371/journal.pone.0165906

    • NAID

      120005868499

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] In Vivo Choroidal Vascular Lesions in Diabetes on Swept-Source Optical Coherence Tomography.2016

    • Author(s)
      Murakami T, Uji A, Suzuma K, Dodo Y, Yoshitake S, Ghashut R, Yoza R, Fujimoto M, Yoshimura N.
    • Journal Title

      Plos One

      Volume: 11 Issue: 8 Pages: e0160317-e0160317

    • DOI

      10.1371/journal.pone.0160317

    • NAID

      120005829427

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Relationship between Functional and Structural Changes in Diabetic Vessels in Optical Coherence Tomography Angiography.2016

    • Author(s)
      Miwa Y, Murakami T, Suzuma K, Uji A, Yoshitake S, Fujimoto M, Yoshitake T, Tamura Y, Yoshimura N.
    • Journal Title

      Sci Rep

      Volume: 6 Issue: 1 Pages: 29064-29064

    • DOI

      10.1038/srep29064

    • NAID

      120005774671

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between retinal hemorrhagic pattern and macular perfusion status in eyes with acute branch retinal vein occlusion.2016

    • Author(s)
      Muraoka Y, Uji A, Tsujikawa A, Murakami T, Ooto S, Suzuma K, Takahashi A, Iida Y, Miwa Y, Hata M, Yoshimura N.
    • Journal Title

      Sci Rep

      Volume: 6 Issue: 1 Pages: 28554-28554

    • DOI

      10.1038/srep28554

    • NAID

      120005774666

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Characterization of Inner Retinal Spots With Inverted Reflectivity on En Face Optical Coherence Tomography in Diabetic Retinopathy.2016

    • Author(s)
      Yoza R, Murakami T, Uji A, Suzuma K, Yoshitake S, Dodo Y, Ghashut R, Fujimoto M, Miwa Y, Yoshimura N.
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 57 Issue: 4 Pages: 1862-1870

    • DOI

      10.1167/iovs.16-19171

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Enhanced-Resolution Optical Coherence Tomography Imaging.2016

    • Author(s)
      Uji A, Murakami T, Arichika S, Muraoka Y, Yoshitake S, Dodo Y, Yoshimura N.
    • Journal Title

      Ophthalmologica.

      Volume: 235 Issue: 3 Pages: 163-172

    • DOI

      10.1159/000443971

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Cotton wool spots after anti-vascular endothelial growth factor therapy for macular edema associated with central retinal vein occlusion.2016

    • Author(s)
      Kida T, Tsujikawa A, Muraoka Y, Harino S, Osaka R, Murakami T, Ooto S, Suzuma K, Morishita S, Fukumoto M, Suzuki H, Ikeda T.
    • Journal Title

      Ophthalmologica

      Volume: 235 Issue: 2 Pages: 106-113

    • DOI

      10.1159/000443622

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Kallikrein-Kinin System: An Emerging Competitor or Collaborator for VEGF in Diabetic Macular Edema?2015

    • Author(s)
      Murakami T
    • Journal Title

      Diabetes

      Volume: 64 Issue: 10 Pages: 3350-3352

    • DOI

      10.2337/db15-0746

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Foveal Damage Due to Subfoveal Hemorrhage Associated with Branch Retinal Vein Occlusion.2015

    • Author(s)
      Muraoka Y, Tsujikawa A, Takahashi A, Iida Y, Murakami T, Ooto S, Suzuma K, Uji A, Yoshimura N.
    • Journal Title

      PLoS One

      Volume: 10 Issue: 12 Pages: e0144894-e0144894

    • DOI

      10.1371/journal.pone.0144894

    • NAID

      120005763408

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Potential measurement errors due to image enlargement in optical coherence tomography imaging.2015

    • Author(s)
      Uji A, Murakami T, Muraoka Y, Hosoda Y, Yoshitake S, Dodo Y, Arichika S, Yoshimura N.
    • Journal Title

      PLoS One

      Volume: 10 Issue: 5 Pages: e0128512-e0128512

    • DOI

      10.1371/journal.pone.0128512

    • NAID

      120005756253

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Macular morphologic findings on optical coherence tomography after microincision vitrectomy for proliferative diabetic retinopathy.2015

    • Author(s)
      Murakami T, Uji A, Ogino K, Unoki N, Yoshitake S, Dodo Y, Horii T, Nishijima K, Yoshimura N.
    • Journal Title

      Jpn J Ophthalmol.

      Volume: 59 Issue: 4 Pages: 236-243

    • DOI

      10.1007/s10384-015-0382-4

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Disorganized retinal lamellar structures in nonperfused areas of diabetic retinopathy.2015

    • Author(s)
      Dodo Y, Murakami T, Uji A, Yoshitake S, Yoshimura N.
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 56 Issue: 3 Pages: 2012-2022

    • DOI

      10.1167/iovs.14-15924

    • Related Report
      2015 Research-status Report 2014 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Clinical relevance of quantified fundus autofluorescence in diabetic macular oedema.2015

    • Author(s)
      Yoshitake S, Murakami T, Uji A, Unoki N, Dodo Y, Horii T, Yoshimura N.
    • Journal Title

      Eye (Lond)

      Volume: 29 Issue: 5 Pages: 662-669

    • DOI

      10.1038/eye.2015.25

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Optical coherence tomographic reflectivity of cystoid spaces is related to recurrent diabetic macular edema after triamcinolone2015

    • Author(s)
      Horii T, Murakami T, Akagi T, Uji A, Ueda-Arakawa N, Nishijima K, Yoshimura N
    • Journal Title

      Retina

      Volume: 35 Issue: 2 Pages: 264-271

    • DOI

      10.1097/iae.0000000000000282

    • Related Report
      2015 Research-status Report 2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Integrative understanding of macular morphologic patterns in diabetic retinopathy based on self-organizing map.2014

    • Author(s)
      Murakami T, Ueda-Arakawa N, Nishijima K, Uji A, Horii T, Ogino K, Yoshimura N.
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 55 Issue: 3 Pages: 1994-2003

    • DOI

      10.1167/iovs.13-13417

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Qualitative and quantitative characteristics of near-infrared autofluorescence in diabetic macular edema.2014

    • Author(s)
      Yoshitake S, Murakami T, Horii T, Uji A, Ogino K, Unoki N, Nishijima K, Yoshimura N.
    • Journal Title

      Ophthalmology

      Volume: 121 Issue: 5 Pages: 1036-1044

    • DOI

      10.1016/j.ophtha.2013.11.033

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Hyperreflective foci in outer retina predictive of photoreceptor damage and poor vision after vitrectomy for diabetic macular edema.2014

    • Author(s)
      Nishijima K, Murakami T, Hirashima T, Uji A, Akagi T, Horii T, Ueda-Arakawa N, Muraoka Y, Yoshimura N.
    • Journal Title

      Retina

      Volume: 34 Issue: 4 Pages: 732-740

    • DOI

      10.1097/iae.0000000000000005

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] 糖尿病黄斑浮腫に対するラニビズマブの治療効果と黄斑部鼻側における嚢胞様腔との関係2016

    • Author(s)
      森雄貴、村上智昭、石原健司、吉武信、藤本雅大、百々蓉子、吉武達哉、三輪裕子、鈴間潔
    • Organizer
      第70回日本臨床眼科学会
    • Place of Presentation
      京都
    • Year and Date
      2016-11-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] 糖尿病黄斑浮腫における抗fumarase抗体の臨床的意義2016

    • Author(s)
      村上智昭、吉武信、吉武達哉、石原健司、藤本雅大、百々蓉子、三輪裕子、鈴間潔
    • Organizer
      第70回日本臨床眼科学会
    • Place of Presentation
      京都
    • Year and Date
      2016-11-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] 村上智昭、森雄貴、石原健司、吉武信、藤本雅大、百々蓉子、吉武達哉、三輪裕子、鈴間潔2016

    • Author(s)
      糖尿病黄斑浮腫における黄斑部視細胞障害へのラニビズマブの影響
    • Organizer
      第22回日本糖尿病眼学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2016-10-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] Identification of Anti-Hexokinase-1 Antibody in the Sera from Patients with Diabetic Macular Edema2016

    • Author(s)
      Tatsuya Yoshitake; Tomoaki Murakami; Kiyoshi Suzuma; Shin Yoshitake; Akihito Uji; Masahiro Fujimoto; Yuko Miwa; Nagahisa Yoshimura
    • Organizer
      ARVO annual meeting
    • Place of Presentation
      Seattle, USA
    • Year and Date
      2016-05-01
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Comparison of Retinal Vascular Imaging between Optical Coherence Tomography Angiography and En-Face Optical Coherence Tomography in Diabetic Retinopathy2016

    • Author(s)
      Yuko Miwa; Tomoaki Murakami; Kiyoshi Suzuma; Akihito Uji; Shin Yoshitake; Masahiro Fujimoto; Tatsuya Yoshitake; Nagahisa Yoshimura
    • Organizer
      ARVO annual meeting
    • Place of Presentation
      Seattle, USA
    • Year and Date
      2016-05-01
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 糖尿病黄斑浮腫における抗hexokinase 1抗体の定量的解析2016

    • Author(s)
      吉武達哉、村上智昭、鈴間潔、宇治彰人、吉武信、藤本雅大、三輪裕子、百々蓉子、吉村長久
    • Organizer
      第120回日本眼科学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2016-04-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] 糖尿病網膜症におけるOCT angiographyとOCTによる網膜血管描出の比較2016

    • Author(s)
      三輪裕子、村上智昭、鈴間潔、宇治彰人、吉武信、藤本雅大、吉武達哉、吉村長久
    • Organizer
      第120回日本眼科学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2016-04-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] Anti-fumarase antibody promotes photoreceptor damage in diabetic macular edema2015

    • Author(s)
      Yoshitake S, Murakami T, Dodo Y, Suzuma K, Uji A, Fujimoto M, Yoshimura N.
    • Organizer
      ARVO Meeting
    • Place of Presentation
      Denver
    • Year and Date
      2015-05-03
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Proposed morphological patterns in age-related macular degeneration based on self-organizing map2015

    • Author(s)
      WakazonoT, Murakami T, Miyake M, Yamashiro K, Ooto S, Tamura H, Oishi A, Nakanishi H, Hata M, Yoshimura N.
    • Organizer
      ARVO Meeting
    • Place of Presentation
      Denver
    • Year and Date
      2015-05-03
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Automatic detection of hyperreflective foci on en face images of swept-source optical coherence tomography in diabetic retinopathy2015

    • Author(s)
      GHASHUT R, Murakami T, Uji A, Suzuma K, Fujimoto M, Yoshitake S, Dodo Y, Yoza R, Yoshimura N.
    • Organizer
      ARVO Meeting
    • Place of Presentation
      Denver
    • Year and Date
      2015-05-03
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Novel patchy lesions in inner retinal layers of diabetic retinopathy using en face optical coherence tomography2015

    • Author(s)
      Yoza R, Murakami T, Uji A, Suzuma K, Fujimoto M, Yoshitake S, Dodo Y, GHASHUT R, Yoshimura N.
    • Organizer
      ARVO Meeting
    • Place of Presentation
      Denver
    • Year and Date
      2015-05-03
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Three-dimensional vascular remodeling in inner nuclear layer using swept-source optical coherence tomography in diabetic retinopathy2015

    • Author(s)
      Murakami T, Dodo Y, Suzuma K, Uji A, Yoshitake S, Fujimoto M, GHASHUT R, Yoza R, Yoshimura N.
    • Organizer
      ARVO Meeting
    • Place of Presentation
      Denver
    • Year and Date
      2015-05-03
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Decreased levels of parafoveal fundus autofluorescence in diabetic macular edema2014

    • Author(s)
      Shin Yoshitake, MD, Tomoaki Murakami, MD, Akihito Uji, MD, Noriyuki Unoki, MD,
    • Organizer
      ARVO annual meeting
    • Place of Presentation
      Orlando
    • Year and Date
      2014-05-04 – 2014-05-08
    • Related Report
      2014 Research-status Report
  • [Presentation] Optical coherence tomographic findings of nonperfusion areas in diabetic retinopathy2014

    • Author(s)
      Murakami T, Uji A, Unoki N, Yoshitake S, Dodo Y, Nishijima K, Yoshimura N
    • Organizer
      ARVO annual meeting
    • Place of Presentation
      Orlando
    • Year and Date
      2014-05-04 – 2014-05-08
    • Related Report
      2014 Research-status Report
  • [Presentation] White dots as a novel marker of diabetic retinopathy severity in ultrawide field imaging2014

    • Author(s)
      Dodo Y, Murakami T, Unoki N, Ogino K, Uji A, Yoshitake S, Yoshimura N
    • Organizer
      ARVO annual meeting
    • Place of Presentation
      Orlando
    • Year and Date
      2014-05-04 – 2014-05-08
    • Related Report
      2014 Research-status Report
  • [Presentation] 超広角走査レーザー検眼鏡を用いた糖尿病網膜症におけるwhite dotの観察2014

    • Author(s)
      百々蓉子 村上智昭 鵜木則之 宇治彰人 吉武信 大石真秀 吉村長久
    • Organizer
      第118回 日本眼科学会総会
    • Place of Presentation
      東京
    • Year and Date
      2014-04-02 – 2014-04-06
    • Related Report
      2014 Research-status Report
  • [Presentation] 糖尿病黄斑浮腫における視細胞障害と短波長光及び赤外光眼底自発蛍光2014

    • Author(s)
      吉武信 村上智昭 宇治彰人 鵜木則之 大石真秀 百々蓉子 西嶋一晃 吉村長久
    • Organizer
      第118回 日本眼科学会総会
    • Place of Presentation
      東京
    • Year and Date
      2014-04-02 – 2014-04-06
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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