The role of periostin in the pathogenesis of retinopathy of prematurity (ROP) and the effect of 2 anti-vascular endothelial growth factors in the treatment of ROP
| Project/Area Number |
26462654
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Kindai University |
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Principal Investigator |
KUSAKA Shunji 近畿大学, 医学部附属病院, 教授 (60260387)
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| Co-Investigator(Kenkyū-buntansha) |
國吉 一樹 近畿大学, 医学部, 講師 (30234470)
杉岡 孝二 近畿大学, 医学部, 講師 (50399119)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 未熟児網膜症 / 抗血管内皮増殖因子（VEGF）抗体 / Periostin / 硝子体 / 抗血管内皮増殖因子（VEGF)抗体 / periostin / 抗血管内皮増殖因子(VEGF)抗体 |
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| Outline of Final Research Achievements |
Intravitreal injection of ranibizumab (IVR) was performed in 27 eyes of 14 patients with severe retinopathy of prematurity (ROP). In each eyes, improvement of vascular dilatation and tortuosity, regression of tunica vasculosa lentis, and/or whitening of fibrovascular membranes was observed. Thus, IVR seemed to be effective in reducing disease activity in all eyes. However, reactivation was seen in 7 eyes at 7.3 weeks (mean) after IVR. Suppression of serum vascular endothelial growth factor was observed only at one day, but not 1, 2, and 4 weeks after IVR, compared with that of pre-IVR.
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Report
(4 results)
Research Products
(29 results)
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[Journal Article] Novel nonsense and splice site mutations in CRB1 gene in two Japanese patients with early-onset retinal dystrophy.2015
Author(s)
Kuniyoshi K, Ikeo K, Sakuramoto H, Furuno M, Yoshitake K, Hatsukawa Y, Nakao A, Tsunoda K, Kusaka S, Shimomura Y, Iwata T.
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Journal Title
Doc Ophthalmol
Volume: 130
Pages: 49-55
Related Report
Peer Reviewed
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[Presentation] ROP Treatment2016
Author(s)
Shuji Kusaka
Organizer
13th International Congress of the Middle East Africa Council of Ophthalmology
Place of Presentation
BAHRAIN INTERNATIONAL EXHIBITION & CONVENTION CENTRE(バーレーン)
Related Report
Int'l Joint Research / Invited
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[Presentation] Surgery for Coats Disease.2016
Author(s)
Shuji Kusaka
Organizer
The 10th Congress of the Asia-Pacific Vitreo-retina Society
Place of Presentation
Bangkok Convention Cente（バンコク）
Related Report
Int'l Joint Research / Invited
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